Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 2002 Jun;86(6):396–399. doi: 10.1136/adc.86.6.396

The UK Hib vaccine experience

P Heath 1, J McVernon 1
PMCID: PMC1762993  PMID: 12023165

Full Text

The Full Text of this article is available as a PDF (96.7 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson E. C., Begg N. T., Crawshaw S. C., Hargreaves R. M., Howard A. J., Slack M. P. Epidemiology of invasive Haemophilus influenzae infections in England and Wales in the pre-vaccination era (1990-2). Epidemiol Infect. 1995 Aug;115(1):89–100. doi: 10.1017/s0950268800058155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baraff L. J., Lee S. I., Schriger D. L. Outcomes of bacterial meningitis in children: a meta-analysis. Pediatr Infect Dis J. 1993 May;12(5):389–394. doi: 10.1097/00006454-199305000-00008. [DOI] [PubMed] [Google Scholar]
  3. Barbour M. L., Booy R., Crook D. W., Griffiths H., Chapel H. M., Moxon E. R., Mayon-White D. Haemophilus influenzae type b carriage and immunity four years after receiving the Haemophilus influenzae oligosaccharide-CRM197 (HbOC) conjugate vaccine. Pediatr Infect Dis J. 1993 Jun;12(6):478–484. doi: 10.1097/00006454-199306000-00005. [DOI] [PubMed] [Google Scholar]
  4. Barbour M. L., Mayon-White R. T., Coles C., Crook D. W., Moxon E. R. The impact of conjugate vaccine on carriage of Haemophilus influenzae type b. J Infect Dis. 1995 Jan;171(1):93–98. doi: 10.1093/infdis/171.1.93. [DOI] [PubMed] [Google Scholar]
  5. Booy R., Heath P. T., Slack M. P., Begg N., Moxon E. R. Vaccine failures after primary immunisation with Haemophilus influenzae type-b conjugate vaccine without booster. Lancet. 1997 Apr 26;349(9060):1197–1202. doi: 10.1016/s0140-6736(96)06392-1. [DOI] [PubMed] [Google Scholar]
  6. Booy R., Hodgson S. A., Slack M. P., Anderson E. C., Mayon-White R. T., Moxon E. R. Invasive Haemophilus influenzae type b disease in the Oxford region (1985-91). Arch Dis Child. 1993 Aug;69(2):225–228. doi: 10.1136/adc.69.2.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Booy R., Hodgson S., Carpenter L., Mayon-White R. T., Slack M. P., Macfarlane J. A., Haworth E. A., Kiddle M., Shribman S., Roberts J. S. Efficacy of Haemophilus influenzae type b conjugate vaccine PRP-T. Lancet. 1994 Aug 6;344(8919):362–366. doi: 10.1016/s0140-6736(94)91400-1. [DOI] [PubMed] [Google Scholar]
  8. Booy R., Taylor S. A., Dobson S. R., Isaacs D., Sleight G., Aitken S., Griffiths H., Chapel H., Mayon-White R. T., Macfarlane J. A. Immunogenicity and safety of PRP-T conjugate vaccine given according to the British accelerated immunisation schedule. Arch Dis Child. 1992 Apr;67(4):475–478. doi: 10.1136/adc.67.4.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Claesson B. A., Schneerson R., Lagergård T., Trollfors B., Taranger J., Johansson J., Bryla D., Robbins J. B. Persistence of serum antibodies elicited by Haemophilus influenzae type b-tetanus toxoid conjugate vaccine in infants vaccinated at 3, 5 and 12 months of age. Pediatr Infect Dis J. 1991 Aug;10(8):560–564. doi: 10.1097/00006454-199108000-00002. [DOI] [PubMed] [Google Scholar]
  10. Eskola J., Ward J., Dagan R., Goldblatt D., Zepp F., Siegrist C. A. Combined vaccination of Haemophilus influenzae type b conjugate and diphtheria-tetanus-pertussis containing acellular pertussis. Lancet. 1999 Dec 11;354(9195):2063–2068. doi: 10.1016/S0140-6736(99)04377-9. [DOI] [PubMed] [Google Scholar]
  11. Fernandez J., Levine O. S., Sanchez J., Balter S., LaClaire L., Feris J., Romero-Steiner S. Prevention of Haemophilus influenzae type b colonization by vaccination: correlation with serum anti-capsular IgG concentration. J Infect Dis. 2000 Oct 9;182(5):1553–1556. doi: 10.1086/315870. [DOI] [PubMed] [Google Scholar]
  12. Galil K., Singleton R., Levine O. S., Fitzgerald M. A., Bulkow L., Getty M., Perkins B. A., Parkinson A. Reemergence of invasive Haemophilus influenzae type b disease in a well-vaccinated population in remote Alaska. J Infect Dis. 1999 Jan;179(1):101–106. doi: 10.1086/314569. [DOI] [PubMed] [Google Scholar]
  13. Goldblatt D., Miller E., McCloskey N., Cartwright K. Immunological response to conjugate vaccines in infants: follow up study. BMJ. 1998 May 23;316(7144):1570–1571. doi: 10.1136/bmj.316.7144.1569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hargreaves R. M., Slack M. P., Howard A. J., Anderson E., Ramsay M. E. Changing patterns of invasive Haemophilus influenzae disease in England and Wales after introduction of the Hib vaccination programme. BMJ. 1996 Jan 20;312(7024):160–161. doi: 10.1136/bmj.312.7024.160. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Heath P. T., Booy R., Azzopardi H. J., Slack M. P., Bowen-Morris J., Griffiths H., Ramsay M. E., Deeks J. J., Moxon E. R. Antibody concentration and clinical protection after Hib conjugate vaccination in the United Kingdom. JAMA. 2000 Nov 8;284(18):2334–2340. doi: 10.1001/jama.284.18.2334. [DOI] [PubMed] [Google Scholar]
  16. Heath P. T., Booy R., Azzopardi H. J., Slack M. P., Fogarty J., Moloney A. C., Ramsay M. E., Moxon E. R. Non-type b Haemophilus influenzae disease: clinical and epidemiologic characteristics in the Haemophilus influenzae type b vaccine era. Pediatr Infect Dis J. 2001 Mar;20(3):300–305. doi: 10.1097/00006454-200103000-00016. [DOI] [PubMed] [Google Scholar]
  17. Heath P. T., Bowen-Morris J., Griffiths D., Griffiths H., Crook D. W., Moxon E. R. Antibody persistence and Haemophilus influenzae type b carriage after infant immunisation with PRP-T. Arch Dis Child. 1997 Dec;77(6):488–492. doi: 10.1136/adc.77.6.488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Heath P. T. Haemophilus influenzae type b conjugate vaccines: a review of efficacy data. Pediatr Infect Dis J. 1998 Sep;17(9 Suppl):S117–S122. doi: 10.1097/00006454-199809001-00005. [DOI] [PubMed] [Google Scholar]
  19. Howard A. J., Dunkin K. T., Musser J. M., Palmer S. R. Epidemiology of Haemophilus influenzae type b invasive disease in Wales. BMJ. 1991 Aug 24;303(6800):441–445. doi: 10.1136/bmj.303.6800.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Kauppi M., Eskola J., Käyhty H. Anti-capsular polysaccharide antibody concentrations in saliva after immunization with Haemophilus influenzae type b conjugate vaccines. Pediatr Infect Dis J. 1995 Apr;14(4):286–294. doi: 10.1097/00006454-199504000-00008. [DOI] [PubMed] [Google Scholar]
  21. Käyhty H., Peltola H., Karanko V., Mäkelä P. H. The protective level of serum antibodies to the capsular polysaccharide of Haemophilus influenzae type b. J Infect Dis. 1983 Jun;147(6):1100–1100. doi: 10.1093/infdis/147.6.1100. [DOI] [PubMed] [Google Scholar]
  22. O'Brien H. Hib immunisation catch up programme in North East Thames. Commun Dis Rep CDR Rev. 1994 Feb 4;4(2):R17–R18. [PubMed] [Google Scholar]
  23. Peltola H., Käyhty H., Sivonen A., Mäkelä H. Haemophilus influenzae type b capsular polysaccharide vaccine in children: a double-blind field study of 100,000 vaccinees 3 months to 5 years of age in Finland. Pediatrics. 1977 Nov;60(5):730–737. [PubMed] [Google Scholar]
  24. Peltola H. Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates. Clin Microbiol Rev. 2000 Apr;13(2):302–317. doi: 10.1128/cmr.13.2.302-317.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Rushdy A., Ramsay M., Heath P. T., Azzopardi H. J., Slack M. P. Infant Hib vaccination and herd immunity. J Pediatr. 1999 Feb;134(2):253–254. doi: 10.1016/s0022-3476(99)70438-5. [DOI] [PubMed] [Google Scholar]
  26. Sarangi J., Cartwright K., Stuart J., Brookes S., Morris R., Slack M. Invasive Haemophilus influenzae disease in adults. Epidemiol Infect. 2000 Jun;124(3):441–447. doi: 10.1017/s0950268899003611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Takala A. K., Eskola J., Leinonen M., Käyhty H., Nissinen A., Pekkanen E., Mäkelä P. H. Reduction of oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with an Hib conjugate vaccine. J Infect Dis. 1991 Nov;164(5):982–986. doi: 10.1093/infdis/164.5.982. [DOI] [PubMed] [Google Scholar]
  28. Tudor-Williams G., Frankland J., Isaacs D., Mayon-White R. T., MacFarlane J. A., Slack M. P., Anderson E., Rees D. G., Moxon E. R. Haemophilus influenzae type b disease in the Oxford region. Arch Dis Child. 1989 Apr;64(4):517–519. doi: 10.1136/adc.64.4.517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Washburn L. K., O'Shea T. M., Gillis D. C., Block S. M., Abramson J. S. Response to Haemophilus influenzae type b conjugate vaccine in chronically ill premature infants. J Pediatr. 1993 Nov;123(5):791–794. doi: 10.1016/s0022-3476(05)80862-5. [DOI] [PubMed] [Google Scholar]
  30. Weinberg G. A., Einhorn M. S., Lenoir A. A., Granoff P. D., Granoff D. M. Immunologic priming to capsular polysaccharide in infants immunized with Haemophilus influenzae type b polysaccharide-Neisseria meningitidis outer membrane protein conjugate vaccine. J Pediatr. 1987 Jul;111(1):22–27. doi: 10.1016/s0022-3476(87)80336-0. [DOI] [PubMed] [Google Scholar]
  31. Wenger J. D., Pierce R., Deaver K., Franklin R., Bosley G., Pigott N., Broome C. V. Invasive Haemophilus influenzae disease: a population-based evaluation of the role of capsular polysaccharide serotype. Haemophilus Influenzae Study Group. J Infect Dis. 1992 Jun;165 (Suppl 1):S34–S35. doi: 10.1093/infdis/165-supplement_1-s34. [DOI] [PubMed] [Google Scholar]
  32. van Alphen L., Spanjaard L., van der Ende A., Schuurman I., Dankert J. Effect of nationwide vaccination of 3-month-old infants in The Netherlands with conjugate Haemophilus influenzae type b vaccine: high efficacy and lack of herd immunity. J Pediatr. 1997 Dec;131(6):869–873. doi: 10.1016/s0022-3476(97)70035-0. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES