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. 1985 Jul;28(1):157–159. doi: 10.1128/aac.28.1.157

Specific inhibition of spermidine synthesis in Mycobacteria spp. by the dextro isomer of ethambutol.

L G Paulin, E E Brander, H J Pösö
PMCID: PMC176332  PMID: 4037776

Abstract

Only the dextro isomer of ethambutol inhibited mycobacterial spermidine synthase and spermidine biosynthesis. Inhibition of mycobacterial spermidine synthase appeared to be specific. Spermidine synthase from Mycobacterium fortuitum, which was resistant to ethambutol in vitro, required a higher concentration of ethambutol for its inhibition than the enzyme of susceptible Mycobacterium bovis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bitonti A. J., McCann P. P., Sjoerdsma A. Restriction of bacterial growth by inhibition of polyamine biosynthesis by using monofluoromethylornithine, difluoromethylarginine and dicyclohexylammonium sulphate. Biochem J. 1982 Nov 15;208(2):435–441. doi: 10.1042/bj2080435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. FORBES M., KUCK N. A., PEETS E. A. EFFECT OF ETHAMBUTOL ON NUCLEIC ACID METABOLISM IN MYCOBACTERIUM SMEGMATIS AND ITS REVERSAL BY POLYAMINES AND DIVALENT CATIONS. J Bacteriol. 1965 May;89:1299–1305. doi: 10.1128/jb.89.5.1299-1305.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Jänne J., Pösö H., Raina A. Polyamines in rapid growth and cancer. Biochim Biophys Acta. 1978 Apr 6;473(3-4):241–293. doi: 10.1016/0304-419x(78)90015-x. [DOI] [PubMed] [Google Scholar]
  4. MASTER R. W. POSSIBLE SYNTHESIS OF POLYRIBONUCLEOTIDES OF KNOWN BASE-TRIPLET SEQUENCES. Nature. 1965 Apr 3;206:93–93. doi: 10.1038/206093b0. [DOI] [PubMed] [Google Scholar]
  5. Paulin L., Vehmaanperä J., Nykänen I., Pösö H. GTP-insensitive ornithine decarboxylase in acetobacteria able to synthesize spermine. Biochem Biophys Res Commun. 1983 Jul 29;114(2):779–784. doi: 10.1016/0006-291x(83)90849-5. [DOI] [PubMed] [Google Scholar]
  6. Pegg A. E., Bitonti A. J., McCann P. P., Coward J. K. Inhibition of bacterial aminopropyltransferases by S-adenosyl-1,8-diamino-3-thiooctane and by dicyclohexylamine. FEBS Lett. 1983 May 8;155(2):192–196. doi: 10.1016/0014-5793(82)80600-5. [DOI] [PubMed] [Google Scholar]
  7. Pöso H., Paulin L., Brander E. Specific inhibition of spermidine synthase from mycobacteria by ethambutol. Lancet. 1983 Dec 17;2(8364):1418–1418. doi: 10.1016/s0140-6736(83)90943-1. [DOI] [PubMed] [Google Scholar]
  8. Pösö H., Hannonen P., Himberg J. J., Jänne J. Adenosylmethionine decarboxylase from various organisms: relation of the putrescine activation of the enzyme to the ability of the organism to synthesize spermine. Biochem Biophys Res Commun. 1976 Jan 12;68(1):227–234. doi: 10.1016/0006-291x(76)90033-4. [DOI] [PubMed] [Google Scholar]
  9. Raina A., Cohen S. S. Polyamines and RNA synthesis in a polyauxotrophic strain of E. coli. Proc Natl Acad Sci U S A. 1966 Jun;55(6):1587–1593. doi: 10.1073/pnas.55.6.1587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Shepherd R. G., Baughn C., Cantrall M. L., Goodstein B., Thomas J. P., Wilkinson R. G. Structure-activity studies leading to ethambutol, a new type of antituberculous compound. Ann N Y Acad Sci. 1966 Apr 20;135(2):686–710. doi: 10.1111/j.1749-6632.1966.tb45516.x. [DOI] [PubMed] [Google Scholar]
  11. Tabor C. W., Tabor H. Polyamines. Annu Rev Biochem. 1984;53:749–790. doi: 10.1146/annurev.bi.53.070184.003533. [DOI] [PubMed] [Google Scholar]
  12. Tabor H. Polyamine biosynthesis in Escherichia coli: construction of polyamine-deficient mutants. Med Biol. 1981 Dec;59(5-6):389–393. [PubMed] [Google Scholar]

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