Abstract
The efficacy and safety of amoxicillin-clavulanic acid were compared with those of co-trimoxazole in the treatment of acute urinary tract infections. A total of 104 patients (mean age, 52 years) with clinical and laboratory evidence of acute urinary tract infection were enrolled in the study. Characteristics and infecting organisms were equivalent in both groups of patients. Escherichia coli was the predominant bacteria pathogen in both groups. Both drugs resulted in clinical improvement in 100% of the patients; bacteriological cure after the termination of therapy was 95% with amoxicillin-clavulanic acid and 83% with co-trimoxazole (P less than 0.001). Side effects were not severe enough to necessitate discontinuation of the antimicrobial agents. Amoxicillin-clavulanic acid is effective and safe therapy for acute urinary tract infections caused by susceptible bacteria.
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Selected References
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- Ball A. P., Geddes A. M., Davey P. G., Farrell I. D., Brookes G. R. Clavulanic acid and amoxycillin: a clinical, bacteriological, and pharmacological study. Lancet. 1980 Mar 22;1(8169):620–623. doi: 10.1016/s0140-6736(80)91118-6. [DOI] [PubMed] [Google Scholar]
- Dumon L., Adriaens P., Anné J., Eyssen H. Effect of clavulanic acid on the minimum inhibitory concentration of benzylpenicillin, ampicillin, carbenicillin, or cephalothin against clinical isolates resistant to beta-lactam antibiotics. Antimicrob Agents Chemother. 1979 Feb;15(2):315–317. doi: 10.1128/aac.15.2.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Frisch J. M. Clinical experience with adverse reactions to trimethoprim-sulfamethoxazole. J Infect Dis. 1973 Nov;128(Suppl):607–p. doi: 10.1093/infdis/128.supplement_3.s607. [DOI] [PubMed] [Google Scholar]
- Neu H. C., Fu K. P. Clavulanic acid, a novel inhibitor of beta-lactamases. Antimicrob Agents Chemother. 1978 Nov;14(5):650–655. doi: 10.1128/aac.14.5.650. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reading C., Cole M. Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May;11(5):852–857. doi: 10.1128/aac.11.5.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reading C., Farmer T. The inhibition of beta-lactamases from gram-negative bacteria by clavulanic acid. Biochem J. 1981 Dec 1;199(3):779–787. doi: 10.1042/bj1990779. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith L. G., Sensakovic J. Trimethoprim-sulfamethoxazole. Med Clin North Am. 1982 Jan;66(1):143–156. doi: 10.1016/s0025-7125(16)31448-1. [DOI] [PubMed] [Google Scholar]