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. 1986 Feb;29(2):294–297. doi: 10.1128/aac.29.2.294

Efficacy of the acyclic guanosine analog buciclovir [(R)-9-(3,4-dihydroxybutyl)guanine] in experimental genital herpes.

B Lundgren, A C Ericson, M Berg, R Datema
PMCID: PMC176394  PMID: 3013082

Abstract

The efficacy of the anti-herpesvirus drug buciclovir [(R)-9-(3,4-dihydroxybutyl)guanine] was investigated in guinea pigs and mice infected intravaginally with herpes simplex virus type 2. Topical treatment initiated early after infection was efficacious, in contrast to topical treatment delayed 24 h or more. Systemic treatment of infected mice could not prevent the spread of virus to the brain and mortality. Systemically administered buciclovir had an effect in guinea pigs, even after delayed onset of treatment, but this effect required high doses of the drug. Our results suggest that buciclovir has only a limited effect against herpesvirus infections once the virus is present in the nervous systems of infected animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Collins P., Oliver N. M. Acyclovir treatment of cutaneous herpes in guinea pigs and herpes encephalitis in mice. Am J Med. 1982 Jul 20;73(1A):96–99. doi: 10.1016/0002-9343(82)90072-9. [DOI] [PubMed] [Google Scholar]
  2. Ericson A. C., Larsson A., Aoki F. Y., Yisak W. A., Johansson N. G., Oberg B., Datema R. Antiherpes effects and pharmacokinetic properties of 9-(4-hydroxybutyl) guanine and the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine. Antimicrob Agents Chemother. 1985 May;27(5):753–759. doi: 10.1128/aac.27.5.753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hsiung G. D., Mayo D. R., Lucia H. L., Landry M. L. Genital herpes: pathogenesis and chemotherapy in the guinea pig model. Rev Infect Dis. 1984 Jan-Feb;6(1):33–50. doi: 10.1093/clinids/6.1.33. [DOI] [PubMed] [Google Scholar]
  4. Kern E. R. Acyclovir treatment of experimental genital herpes simplex virus infections. Am J Med. 1982 Jul 20;73(1A):100–108. doi: 10.1016/0002-9343(82)90073-0. [DOI] [PubMed] [Google Scholar]
  5. Kern E. R., Richards J. T., Overall J. C., Jr, Glasgow L. A. Acyclovir treatment of experimental genital herpes simplex virus infections. I. Topical therapy of type 2 and type 1 infections of mice. Antiviral Res. 1983 Nov;3(4):253–267. doi: 10.1016/0166-3542(83)90004-9. [DOI] [PubMed] [Google Scholar]
  6. Lachin J. M. Introduction to sample size determination and power analysis for clinical trials. Control Clin Trials. 1981 Jun;2(2):93–113. doi: 10.1016/0197-2456(81)90001-5. [DOI] [PubMed] [Google Scholar]
  7. Larsson A., Alenius S., Johansson N. G., Oberg B. Antiherpetic activity and mechanism of action of 9-(4-hydroxybutyl)guanine. Antiviral Res. 1983 Aug;3(2):77–86. doi: 10.1016/0166-3542(83)90028-1. [DOI] [PubMed] [Google Scholar]
  8. Larsson A., Oberg B., Alenius S., Hagberg C. E., Johansson N. G., Lindborg B., Stening G. 9-(3,4-dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication. Antimicrob Agents Chemother. 1983 May;23(5):664–670. doi: 10.1128/aac.23.5.664. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Larsson A., Tao P. Z. Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase. Antimicrob Agents Chemother. 1984 Apr;25(4):524–526. doi: 10.1128/aac.25.4.524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Oberg B., Johansson N. G. The relative merits and drawbacks of new nucleoside analogues with clinical potential. J Antimicrob Chemother. 1984 Aug;14 (Suppl A):5–26. doi: 10.1093/jac/14.suppl_a.5. [DOI] [PubMed] [Google Scholar]
  11. Overall J. C., Jr, Kern E. R., Schlitzer R. L., Friedman S. B., Glasgow L. A. Genital herpesvirus hominis infection in mice. I. Development of an experimental model. Infect Immun. 1975 Mar;11(3):476–480. doi: 10.1128/iai.11.3.476-480.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Pronovost A. D., Lucia H. L., Dann P. R., Hsiung G. D. Effect of acyclovir on genital herpes in guinea pigs. J Infect Dis. 1982 Jun;145(6):904–908. doi: 10.1093/infdis/145.6.904. [DOI] [PubMed] [Google Scholar]
  13. Stanberry L. R., Kern E. R., Richards J. T., Abbott T. M., Overall J. C., Jr Genital herpes in guinea pigs: pathogenesis of the primary infection and description of recurrent disease. J Infect Dis. 1982 Sep;146(3):397–404. doi: 10.1093/infdis/146.3.397. [DOI] [PubMed] [Google Scholar]

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