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. 1986 Jul;30(1):101–104. doi: 10.1128/aac.30.1.101

Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids.

M J O'Neill, D H Bray, P Boardman, J D Phillipson, D C Warhurst, W Peters, M Suffness
PMCID: PMC176444  PMID: 3530122

Abstract

Fourteen quassinoids, obtained from simaroubaceous plants, were tested for in vitro antimalarial activity. All of these inhibited the incorporation of [3H]hypoxanthine into Plasmodium falciparum in vitro at concentrations below 0.41 microgram ml-1. The two most potent quassinoids, bruceantin and simalikalactone D, showed 50% inhibitory concentration values of 0.0008 and 0.0009 microgram ml-1, respectively. The results are compared with the antiamoebic, antileukemic, and cytotoxic activities of these compounds reported in the literature.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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