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. 1986 Jul;30(1):147–151. doi: 10.1128/aac.30.1.147

Inhibition of electron transfer and uncoupling effects by emodin and emodinanthrone in Escherichia coli.

T Ubbink-Kok, J A Anderson, W N Konings
PMCID: PMC176453  PMID: 3019234

Abstract

The anthraquinones emodin (1,3,delta-trihydroxy-6-methylanthraquinone) and emodinanthrone (1,3,8-trihydroxy-6-methylanthrone) inhibited respiration-driven solute transport at micromolar concentrations in membrane vesicles of Escherichia coli. This inhibition was enhanced by Ca ions. The inhibitory action on solute transport is caused by inhibition of electron flow in the respiratory chain, most likely at the level between ubiquinone and cytochrome b, and by dissipation of the proton motive force. The uncoupling action was confirmed by studies on the proton motive force in beef heart cytochrome oxidase proteoliposomes. These two effects on energy transduction in cytoplasmic membranes explain the antibiotic properties of emodin and emodinanthrone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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