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. 1986 Jul;30(1):184–186. doi: 10.1128/aac.30.1.184

Comparative efficacy of ciprofloxacin and ceftriaxone in experimental arthritis caused by Escherichia coli.

A S Bayer, D C Norman, I K Blomquist
PMCID: PMC176463  PMID: 2944479

Abstract

Ciprofloxacin was compared with ceftriaxone in a rabbit model of septic arthritis caused by Escherichia coli. Both agents significantly reduced mean E. coli counts in septic joint fluid (P less than 0.0005 versus untreated controls) and also within infected synovial tissue (P less than 0.01 versus controls). Ciprofloxacin regimens caused a higher frequency (P less than 0.05) of synovial tissue sterilization (53%) than did ceftriaxone (25%).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barry A. L., Fass R. J., Anhalt J. P., Neu H. C., Thornsberry C., Tilton R. C., Painter B. G., Washington J. A., 2nd Ciprofloxacin disk susceptibility tests: interpretive zone size standards for 5-microgram disks. J Clin Microbiol. 1985 Jun;21(6):880–883. doi: 10.1128/jcm.21.6.880-883.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bayer A. S., Chow A. W., Louie J. S., Guze L. B. Sternoarticualr pyoarthrosis due to gram-negative bacilli. Report of eight cases. Arch Intern Med. 1977 Aug;137(8):1036–1040. [PubMed] [Google Scholar]
  3. Bayer A. S., Chow A. W., Louie J. S., Nies K. M., Guze L. B. Gram-negative bacillary septic arthritis: clinical, radiographic, therapeutic, and prognostic features. Semin Arthritis Rheum. 1977 Nov;7(2):123–132. doi: 10.1016/0049-0172(77)90018-x. [DOI] [PubMed] [Google Scholar]
  4. Bayer A. S., Norman D., Anderson D. Efficacy of ciprofloxacin in experimental arthritis caused by Escherichia coli--in vitro-in vivo correlations. J Infect Dis. 1985 Oct;152(4):811–816. doi: 10.1093/infdis/152.4.811. [DOI] [PubMed] [Google Scholar]
  5. Goldenberg D. L., Brandt K. D., Cathcart E. S., Cohen A. S. Acute arthritis caused by gram-negative bacilli: a clinical characterization. Medicine (Baltimore) 1974 May;53(3):197–208. doi: 10.1097/00005792-197405000-00003. [DOI] [PubMed] [Google Scholar]
  6. Nagel D. A., Albright J. A., Hollingsworth J. W. Studies on the pathophysiology and some host defense factors in staphylococcal arthritis in the rabbit and on the relationship of aseptic inflammation to infection rate. Yale J Biol Med. 1966 Oct;39(2):119–128. [PMC free article] [PubMed] [Google Scholar]
  7. Neu H. C., Meropol N. J., Fu K. P. Antibacterial activity of ceftriaxone (Ro 13-9904), a beta-lactamase-stable cephalosporin. Antimicrob Agents Chemother. 1981 Mar;19(3):414–423. doi: 10.1128/aac.19.3.414. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pearson R. D., Steigbigel R. T., Davis H. T., Chapman S. W. Method of reliable determination of minimal lethal antibiotic concentrations. Antimicrob Agents Chemother. 1980 Nov;18(5):699–708. doi: 10.1128/aac.18.5.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Sande M. A., Johnson M. L. Antimicrobial therapy of experimental endocarditis caused by Staphylococcus aureus. J Infect Dis. 1975 Apr;131(4):367–375. doi: 10.1093/infdis/131.4.367. [DOI] [PubMed] [Google Scholar]
  10. Schurman D. J., Mirra J., Ding A., Nagel D. A. Experimental E. coli arthritis in the rabbit. A model of infectious and post-infectious inflammatory synovitis. J Rheumatol. 1977 Summer;4(2):118–128. [PubMed] [Google Scholar]
  11. Ward T. T., Steigbigel R. T. Acidosis of synovial fluid correlates with synovial fluid leukocytosis. Am J Med. 1978 Jun;64(6):933–936. doi: 10.1016/0002-9343(78)90446-1. [DOI] [PubMed] [Google Scholar]

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