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. 2000 Jun;82(Suppl 2):ii2–ii5. doi: 10.1136/adc.82.suppl_2.ii2

The burden of childhood asthma

E von Mutius
PMCID: PMC1765082  PMID: 10833469

Abstract

Paediatric asthma is a major clinical concern worldwide and represents a huge burden on family and society. It accounts for a large number of lost school days and may deprive the child of both academic achievement and social interaction. Childhood asthma also places strain on healthcare resources as a result of doctor and hospital visits and the cost of treatment. The prevalence of asthma varies worldwide, possibly because of different exposure to respiratory infection, indoor and outdoor pollution, and diet. Certain risk factors appear to predispose children to developing asthma and atopic disease, including incidence and severity of wheezing, atopy, maternal smoking, and number of fever episodes. This paper discusses the burden, prevalence, and risk factors associated with paediatric asthma.



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Selected References

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  1. Black P. N., Sharpe S. Dietary fat and asthma: is there a connection? Eur Respir J. 1997 Jan;10(1):6–12. doi: 10.1183/09031936.97.10010006. [DOI] [PubMed] [Google Scholar]
  2. Bodner C., Godden D., Seaton A. Family size, childhood infections and atopic diseases. The Aberdeen WHEASE Group. Thorax. 1998 Jan;53(1):28–32. doi: 10.1136/thx.53.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burrows B., Sears M. R., Flannery E. M., Herbison G. P., Holdaway M. D., Silva P. A. Relation of the course of bronchial responsiveness from age 9 to age 15 to allergy. Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 1):1302–1308. doi: 10.1164/ajrccm.152.4.7551386. [DOI] [PubMed] [Google Scholar]
  4. Dales R. E., Schweitzer I., Toogood J. H., Drouin M., Yang W., Dolovich J., Boulet J. Respiratory infections and the autumn increase in asthma morbidity. Eur Respir J. 1996 Jan;9(1):72–77. doi: 10.1183/09031936.96.09010072. [DOI] [PubMed] [Google Scholar]
  5. Duff A. L., Pomeranz E. S., Gelber L. E., Price G. W., Farris H., Hayden F. G., Platts-Mills T. A., Heymann P. W. Risk factors for acute wheezing in infants and children: viruses, passive smoke, and IgE antibodies to inhalant allergens. Pediatrics. 1993 Oct;92(4):535–540. [PubMed] [Google Scholar]
  6. Giosuè S., Casarini M., Ameglio F., Alemanno L., Saltini C., Bisetti A. Minimal dose of aerosolized interferon-alpha in human subjects: biological consequences and side-effects. Eur Respir J. 1996 Jan;9(1):42–46. doi: 10.1183/09031936.96.09010042. [DOI] [PubMed] [Google Scholar]
  7. Horn M. E., Reed S. E., Taylor P. Role of viruses and bacteria in acute wheezy bronchitis in childhood: a study of sputum. Arch Dis Child. 1979 Aug;54(8):587–592. doi: 10.1136/adc.54.8.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Johnston S. L., Pattemore P. K., Sanderson G., Smith S., Campbell M. J., Josephs L. K., Cunningham A., Robinson B. S., Myint S. H., Ward M. E. The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med. 1996 Sep;154(3 Pt 1):654–660. doi: 10.1164/ajrccm.154.3.8810601. [DOI] [PubMed] [Google Scholar]
  9. Kabesch M., Schaal W., Nicolai T., von Mutius E. Lower prevalence of asthma and atopy in Turkish children living in Germany. Eur Respir J. 1999 Mar;13(3):577–582. doi: 10.1183/09031936.99.13357799. [DOI] [PubMed] [Google Scholar]
  10. Lewis S. A., Britton J. R. Consistent effects of high socioeconomic status and low birth order, and the modifying effect of maternal smoking on the risk of allergic disease during childhood. Respir Med. 1998 Oct;92(10):1237–1244. doi: 10.1016/s0954-6111(98)90427-9. [DOI] [PubMed] [Google Scholar]
  11. Martin A. J., McLennan L. A., Landau L. I., Phelan P. D. The natural history of childhood asthma to adult life. Br Med J. 1980 Jun 14;280(6229):1397–1400. doi: 10.1136/bmj.280.6229.1397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Martinez F. D., Wright A. L., Taussig L. M., Holberg C. J., Halonen M., Morgan W. J. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med. 1995 Jan 19;332(3):133–138. doi: 10.1056/NEJM199501193320301. [DOI] [PubMed] [Google Scholar]
  13. Minor T. E., Dick E. C., DeMeo A. N., Ouellette J. J., Cohen M., Reed C. E. Viruses as precipitants of asthmatic attacks in children. JAMA. 1974 Jan 21;227(3):292–298. [PubMed] [Google Scholar]
  14. Negro Alvarez J. M., Hernández García J., Pagán Alemán J. A., García Sellés F. J., López Sánchez J. D., Abellán Alemán A., Rubio del Barrio R. The role of rhinovirus in allergic airway inflammation. Allergol Immunopathol (Madr) 1997 Nov-Dec;25(6):302–309. [PubMed] [Google Scholar]
  15. Nicholson K. G., Kent J., Ireland D. C. Respiratory viruses and exacerbations of asthma in adults. BMJ. 1993 Oct 16;307(6910):982–986. doi: 10.1136/bmj.307.6910.982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Roldaan A. C., Masural N. Viral respiratory infections in asthmatic children staying in a mountain resort. Eur J Respir Dis. 1982 Mar;63(2):140–150. [PubMed] [Google Scholar]
  17. Roorda R. J., Gerritsen J., Van Aalderen W. M., Schouten J. P., Veltman J. C., Weiss S. T., Knol K. Risk factors for the persistence of respiratory symptoms in childhood asthma. Am Rev Respir Dis. 1993 Dec;148(6 Pt 1):1490–1495. doi: 10.1164/ajrccm/148.6_Pt_1.1490. [DOI] [PubMed] [Google Scholar]
  18. Sears M. R. Evolution of asthma through childhood. Clin Exp Allergy. 1998 Nov;28 (Suppl 5):82–91. doi: 10.1046/j.1365-2222.1998.028s5082.x. [DOI] [PubMed] [Google Scholar]
  19. Sporik R., Holgate S. T., Platts-Mills T. A., Cogswell J. J. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990 Aug 23;323(8):502–507. doi: 10.1056/NEJM199008233230802. [DOI] [PubMed] [Google Scholar]
  20. Stein R. T., Sherrill D., Morgan W. J., Holberg C. J., Halonen M., Taussig L. M., Wright A. L., Martinez F. D. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999 Aug 14;354(9178):541–545. doi: 10.1016/S0140-6736(98)10321-5. [DOI] [PubMed] [Google Scholar]
  21. Strachan D. P., Butland B. K., Anderson H. R. Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort. BMJ. 1996 May 11;312(7040):1195–1199. doi: 10.1136/bmj.312.7040.1195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Taylor W. R., Newacheck P. W. Impact of childhood asthma on health. Pediatrics. 1992 Nov;90(5):657–662. [PubMed] [Google Scholar]
  23. Wright A. L., Holberg C. J., Martinez F. D., Morgan W. J., Taussig L. M. Breast feeding and lower respiratory tract illness in the first year of life. Group Health Medical Associates. BMJ. 1989 Oct 14;299(6705):946–949. doi: 10.1136/bmj.299.6705.946. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. von Mutius E. Asthma und Infekte: Risiko oder Schutz? Schweiz Med Wochenschr. 1998 Nov 21;128(47):1833–1839. [PubMed] [Google Scholar]
  25. von Mutius E., Illi S., Hirsch T., Leupold W., Keil U., Weiland S. K. Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children. Eur Respir J. 1999 Jul;14(1):4–11. doi: 10.1034/j.1399-3003.1999.14a03.x. [DOI] [PubMed] [Google Scholar]
  26. von Mutius E., Martinez F. D., Fritzsch C., Nicolai T., Roell G., Thiemann H. H. Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respir Crit Care Med. 1994 Feb;149(2 Pt 1):358–364. doi: 10.1164/ajrccm.149.2.8306030. [DOI] [PubMed] [Google Scholar]
  27. von Mutius E., Weiland S. K., Fritzsch C., Duhme H., Keil U. Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet. 1998 Mar 21;351(9106):862–866. doi: 10.1016/S0140-6736(97)10100-3. [DOI] [PubMed] [Google Scholar]

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