Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1986 Nov;30(5):739–742. doi: 10.1128/aac.30.5.739

In vitro susceptibility of Capnocytophaga species to 29 antimicrobial agents.

J L Rummens, B Gordts, H W Van Landuyt
PMCID: PMC176524  PMID: 3800350

Abstract

A hemoglobin-supplemented medium composed of Columbia agar base supplemented with 1% hemoglobin and 1% Polyvitex was used to investigate the in vitro activity of 29 antimicrobial agents against Capnocytophaga species. Clindamycin was the most active agent, with all strains being inhibited by 0.06 microgram/ml or less. Amoxicillin-clavulanic acid and imipenem were the most active among the beta-lactam antibiotics (MIC for 90% of strains tested [MIC90], 0.50 microgram/ml); other very active drugs were BMY 28142, cefpirome, cefotaxime, ceftazidime, and ceftriaxone (MIC90, 0.06 to 0.50 micrograms/ml), although at least one strain showed resistance to each of these antibiotics (MIC, greater than or equal to 16 micrograms/ml). Ciprofloxacin was the most active among the quinolones, with all strains being inhibited by 0.50 microgram/ml. The MICs of the other four drugs ranged from 0.12 to 4 micrograms/ml. Ampicillin, penicillin G, ticarcillin, aztreonam, and temocillin were moderately active (MIC90, 1 to 8 micrograms/ml; MIC range, less than or equal to 0.03 to greater than 128 micrograms/ml). All strains were uniformly resistant to the aminoglycosides, polymyxin B, vancomycin, trimethoprim, and amphotericin B. Three strains produced beta-lactamase. No significant difference was found between the susceptibility of strains isolated from various sources or patients.

Full text

PDF
739

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appelbaum P. C., Ballard J. O., Eyster M. E. Septicemia due to Capnocytophaga (Bacteroides ocharaceus) in Hodgkin's disease. Ann Intern Med. 1979 Apr;90(4):716–717. doi: 10.7326/0003-4819-90-4-716. [DOI] [PubMed] [Google Scholar]
  2. Coignard S., Malbrunot C., Bor Y., Perrot S., Rouveix E., Dechy H., Dorra M. Endocardite à Capnocytophaga ochracea. Nouv Presse Med. 1982 Apr 10;11(17):1338–1338. [PubMed] [Google Scholar]
  3. De Rautlin de la Roy Y., Grignon B., Grollier G., Paute M. C., Desmaret M. C., Tanzer J. Septicémie à Capnocytophaga sputigena. Nouv Presse Med. 1981 Oct 10;10(36):2992–2992. [PubMed] [Google Scholar]
  4. Forlenza S. W., Newman M. G., Horikoshi A. L., Blachman U. Antimicrobial susceptibility of Capnocytophaga. Antimicrob Agents Chemother. 1981 Jan;19(1):144–146. doi: 10.1128/aac.19.1.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Forlenza S. W., Newman M. G., Lipsey A. I., Siegel S. E., Blachman U. Capnocytophaga sepsis: a newly recognised clinical entity in granulocytopenic patients. Lancet. 1980 Mar 15;1(8168 Pt 1):567–568. doi: 10.1016/s0140-6736(80)91057-0. [DOI] [PubMed] [Google Scholar]
  6. Gandola C., Butler T., Badger S., Cheng E., Beard S. Septicemia caused by Capnocytophaga in a granulocytopenic patient with glossitis. Arch Intern Med. 1980 Jun;140(6):851–852. [PubMed] [Google Scholar]
  7. Gilligan P. H., McCarthy L. R., Bissett B. K. Capnocytophaga ochracea septicemia. J Clin Microbiol. 1981 Apr;13(4):643–645. doi: 10.1128/jcm.13.4.643-645.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Haulk A. A., Sugar A. M., Rushing J. L. Capnocytophaga septicemia. N Engl J Med. 1980 Apr 17;302(16):922–922. doi: 10.1056/NEJM198004173021618. [DOI] [PubMed] [Google Scholar]
  9. Holt S. C., Leadbetter E. R., Socransky S. S. Capnocytophaga: new genus of gram-negative gliding bacteria. II. Morphology and ultrastructure. Arch Microbiol. 1979 Jul;122(1):17–27. doi: 10.1007/BF00408041. [DOI] [PubMed] [Google Scholar]
  10. Kinder S. A., Holt S. C., Korman K. S. Penicillin resistance in the subgingival microbiota associated with adult periodontitis. J Clin Microbiol. 1986 Jun;23(6):1127–1133. doi: 10.1128/jcm.23.6.1127-1133.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Leadbetter E. R., Holt S. C., Socransky S. S. Capnocytophaga: new genus of gram-negative gliding bacteria. I. General characteristics, taxonomic considerations and significance. Arch Microbiol. 1979 Jul;122(1):9–16. doi: 10.1007/BF00408040. [DOI] [PubMed] [Google Scholar]
  12. Mashimo P. A., Yamamoto Y., Nakamura M., Slots J. Selective recovery of oral Capnocytophaga spp. with sheep blood agar containing bacitracin and polymyxin B. J Clin Microbiol. 1983 Feb;17(2):187–191. doi: 10.1128/jcm.17.2.187-191.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Moncharmont D., Miro I., Simonin R., De Micco C. Hépatite granulomateuse à Rickettsia conori. Nouv Presse Med. 1981 Dec 5;10(44):3651–3651. [PubMed] [Google Scholar]
  14. Newman M. G., Socransky S. S., Savitt E. D., Propas D. A., Crawford A. Studies of the microbiology of periodontosis. J Periodontol. 1976 Jul;47(7):373–379. doi: 10.1902/jop.1976.47.7.373. [DOI] [PubMed] [Google Scholar]
  15. Rummens J. L., Fossepre J. M., De Gruyter M., Van de Vyver H., Neyt L., Van Landuyt H. W. Isolation of Capnocytophaga species with a new selective medium. J Clin Microbiol. 1985 Sep;22(3):375–378. doi: 10.1128/jcm.22.3.375-378.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rummens J. L., Verfaillie C., Louwagie A., Boelaert J., Van Landuyt H. W. Capnocytophaga infection: a risk in the immunocompromised host. Acta Clin Belg. 1984;39(2):109–113. doi: 10.1080/22953337.1984.11718990. [DOI] [PubMed] [Google Scholar]
  17. Seger R., Kloeti J., von Graevenitz A., Wüst J., Briner J., Willi U., Siegrist H. Cervical abscess due to Capnocytophaga ochracea. Pediatr Infect Dis. 1982 May-Jun;1(3):170–172. doi: 10.1097/00006454-198205000-00009. [DOI] [PubMed] [Google Scholar]
  18. Socransky S. S., Holt S. C., Leadbetter E. R., Tanner A. C., Savitt E., Hammond B. F. Capnocytophaga: new genus of gram-negative gliding bacteria. III. Physiological characterization. Arch Microbiol. 1979 Jul;122(1):29–33. doi: 10.1007/BF00408042. [DOI] [PubMed] [Google Scholar]
  19. Sutter V. L., Pyeatt D., Kwok Y. Y. In vitro susceptibility of Capnocytophaga strains to 18 antimicrobial agents. Antimicrob Agents Chemother. 1981 Aug;20(2):270–271. doi: 10.1128/aac.20.2.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Walker C. B., Niebloom T. A., Socransky S. S. Agar medium for use in susceptibility testing of bacteria from human periodontal pockets. Antimicrob Agents Chemother. 1979 Oct;16(4):452–457. doi: 10.1128/aac.16.4.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Winn R. E., Chase W. F., Lauderdale P. W., McCleskey F. K. Septic arthritis involving Capnocytophaga ochracea. J Clin Microbiol. 1984 Apr;19(4):538–540. doi: 10.1128/jcm.19.4.538-540.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES