Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1986 Nov;30(5):771–773. doi: 10.1128/aac.30.5.771

Ketoconazole in experimental vaginal candidosis in rats.

O S Kinsman, A E Collard, T J Savage
PMCID: PMC176530  PMID: 3800354

Abstract

Rats in pseudoestrous were treated subcutaneously with ketoconazole at 25 mg/kg twice a day. In both uninfected and infected rats ketoconazole inhibited the cornification of the vaginal epithelium. Thus, ketoconazole, in addition to having an antifungal effect, may aid in the removal of candida by inhibiting the epithelial conditions suitable for hyphal invasion.

Full text

PDF
771

Images in this article

771Image
on p.771
772Image
on p.772

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Grosso D. S., Boyden T. W., Pamenter R. W., Johnson D. G., Stevens D. A., Galgiani J. N. Ketoconazole inhibition of testicular secretion of testosterone and displacement of steroid hormones from serum transport proteins. Antimicrob Agents Chemother. 1983 Feb;23(2):207–212. doi: 10.1128/aac.23.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Kinsman O. S., Collard A. E. Hormonal factors in vaginal candidiasis in rats. Infect Immun. 1986 Sep;53(3):498–504. doi: 10.1128/iai.53.3.498-504.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Larsen B., Galask R. P. Influence of estrogen and normal flora on vaginal candidiasis in the rat. J Reprod Med. 1984 Dec;29(12):863–868. [PubMed] [Google Scholar]
  4. Loose D. S., Kan P. B., Hirst M. A., Marcus R. A., Feldman D. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest. 1983 May;71(5):1495–1499. doi: 10.1172/JCI110903. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Miettinen T. A., Valtonen V. V. Ketoconazole and cholesterol synthesis. Lancet. 1984 Dec 1;2(8414):1271–1271. doi: 10.1016/s0140-6736(84)92814-9. [DOI] [PubMed] [Google Scholar]
  6. Pont A., Williams P. L., Azhar S., Reitz R. E., Bochra C., Smith E. R., Stevens D. A. Ketoconazole blocks testosterone synthesis. Arch Intern Med. 1982 Nov;142(12):2137–2140. [PubMed] [Google Scholar]
  7. Pont A., Williams P. L., Loose D. S., Feldman D., Reitz R. E., Bochra C., Stevens D. A. Ketoconazole blocks adrenal steroid synthesis. Ann Intern Med. 1982 Sep;97(3):370–372. doi: 10.7326/0003-4819-97-3-370. [DOI] [PubMed] [Google Scholar]
  8. Sikka S. C., Swerdloff R. S., Rajfer J. In vitro inhibition of testosterone biosynthesis by ketoconazole. Endocrinology. 1985 May;116(5):1920–1925. doi: 10.1210/endo-116-5-1920. [DOI] [PubMed] [Google Scholar]
  9. Sobel J. D., Muller G. Comparison of ketoconazole, Bay N7133, and Bay L9139 in the treatment of experimental vaginal candidiasis. Antimicrob Agents Chemother. 1983 Sep;24(3):434–436. doi: 10.1128/aac.24.3.434. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sobel J. D., Muller G., McCormick J. F. Experimental chronic vaginal candidosis in rats. Sabouraudia. 1985 Jun;23(3):199–206. doi: 10.1080/00362178585380301. [DOI] [PubMed] [Google Scholar]
  11. Thienpont D., Van Cutsem J., Van Gerven F., Heeres J., Janssen P. A. Ketoconazole -- a new broad spectrum orally active antimycotic. Experientia. 1979 May 15;35(5):606–607. doi: 10.1007/BF01960348. [DOI] [PubMed] [Google Scholar]
  12. Van den Bossche H., Willemsens G., Cools W., Cornelissen F., Lauwers W. F., van Cutsem J. M. In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis. Antimicrob Agents Chemother. 1980 Jun;17(6):922–928. doi: 10.1128/aac.17.6.922. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES