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. 1997 Aug;52(Suppl 3):S16–S21. doi: 10.1136/thx.52.2008.s16

NO: COPD and beyond

A T Jones, T W Evans
PMCID: PMC1765879  PMID: 9381421

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Selected References

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  1. Adnot S., Kouyoumdjian C., Defouilloy C., Andrivet P., Sediame S., Herigault R., Fratacci M. D. Hemodynamic and gas exchange responses to infusion of acetylcholine and inhalation of nitric oxide in patients with chronic obstructive lung disease and pulmonary hypertension. Am Rev Respir Dis. 1993 Aug;148(2):310–316. doi: 10.1164/ajrccm/148.2.310. [DOI] [PubMed] [Google Scholar]
  2. Barbera J. A., Ramirez J., Roca J., Wagner P. D., Sanchez-Lloret J., Rodriguez-Roisin R. Lung structure and gas exchange in mild chronic obstructive pulmonary disease. Am Rev Respir Dis. 1990 Apr;141(4 Pt 1):895–901. doi: 10.1164/ajrccm/141.4_Pt_1.895. [DOI] [PubMed] [Google Scholar]
  3. Barberà J. A., Roger N., Roca J., Rovira I., Higenbottam T. W., Rodriguez-Roisin R. Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease. Lancet. 1996 Feb 17;347(8999):436–440. doi: 10.1016/s0140-6736(96)90011-2. [DOI] [PubMed] [Google Scholar]
  4. Barrett M. L., Willis A. L., Vane J. R. Inhibition of platelet-derived mitogen release by nitric oxide (EDRF). Agents Actions. 1989 Jun;27(3-4):488–491. doi: 10.1007/BF01972860. [DOI] [PubMed] [Google Scholar]
  5. Brett S. J., Evans T. W. Inhaled vasodilator therapy in acute lung injury: first, do NO harm? Thorax. 1995 Aug;50(8):821–823. doi: 10.1136/thx.50.8.821. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Castaing Y., Manier G., Guenard H. Improvement in ventilation-perfusion relationships by almitrine in patients with chronic obstructive pulmonary disease during mechanical ventilation. Am Rev Respir Dis. 1986 Nov;134(5):910–916. doi: 10.1164/arrd.1986.134.5.910. [DOI] [PubMed] [Google Scholar]
  7. Chand N., Altura B. M. Acetylcholine and bradykinin relax intrapulmonary arteries by acting on endothelial cells: role in lung vascular diseases. Science. 1981 Sep 18;213(4514):1376–1379. doi: 10.1126/science.7268440. [DOI] [PubMed] [Google Scholar]
  8. Dantzker D. R., Brook C. J., Dehart P., Lynch J. P., Weg J. G. Ventilation-perfusion distributions in the adult respiratory distress syndrome. Am Rev Respir Dis. 1979 Nov;120(5):1039–1052. doi: 10.1164/arrd.1979.120.5.1039. [DOI] [PubMed] [Google Scholar]
  9. Dinh-Xuan A. T., Higenbottam T. W., Clelland C. A., Pepke-Zaba J., Cremona G., Butt A. Y., Large S. R., Wells F. C., Wallwork J. Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. N Engl J Med. 1991 May 30;324(22):1539–1547. doi: 10.1056/NEJM199105303242203. [DOI] [PubMed] [Google Scholar]
  10. Fletcher E. C., Levin D. C. Cardiopulmonary hemodynamics during sleep in subjects with chronic obstructive pulmonary disease. The effect of short- and long-term oxygen. Chest. 1984 Jan;85(1):6–14. doi: 10.1378/chest.85.1.6. [DOI] [PubMed] [Google Scholar]
  11. France A. J., Prescott R. J., Biernacki W., Muir A. L., MacNee W. Does right ventricular function predict survival in patients with chronic obstructive lung disease? Thorax. 1988 Aug;43(8):621–626. doi: 10.1136/thx.43.8.621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Frostell C. G., Blomqvist H., Hedenstierna G., Lundberg J., Zapol W. M. Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology. 1993 Mar;78(3):427–435. doi: 10.1097/00000542-199303000-00005. [DOI] [PubMed] [Google Scholar]
  13. Frostell C., Fratacci M. D., Wain J. C., Jones R., Zapol W. M. Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation. 1991 Jun;83(6):2038–2047. doi: 10.1161/01.cir.83.6.2038. [DOI] [PubMed] [Google Scholar]
  14. Furchgott R. F., Zawadzki J. V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980 Nov 27;288(5789):373–376. doi: 10.1038/288373a0. [DOI] [PubMed] [Google Scholar]
  15. Garg U. C., Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989 May;83(5):1774–1777. doi: 10.1172/JCI114081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Gerlach H., Rossaint R., Pappert D., Falke K. J. Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest. 1993 Aug;23(8):499–502. doi: 10.1111/j.1365-2362.1993.tb00797.x. [DOI] [PubMed] [Google Scholar]
  17. Greenberg B., Rhoden K., Barnes P. J. Endothelium-dependent relaxation of human pulmonary arteries. Am J Physiol. 1987 Feb;252(2 Pt 2):H434–H438. doi: 10.1152/ajpheart.1987.252.2.H434. [DOI] [PubMed] [Google Scholar]
  18. Hampl V., Archer S. L., Nelson D. P., Weir E. K. Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure. J Appl Physiol (1985) 1993 Oct;75(4):1748–1757. doi: 10.1152/jappl.1993.75.4.1748. [DOI] [PubMed] [Google Scholar]
  19. Hampl V., Cornfield D. N., Cowan N. J., Archer S. L. Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells. Eur Respir J. 1995 Apr;8(4):515–522. [PubMed] [Google Scholar]
  20. Högman M., Frostell C. G., Hedenström H., Hedenstierna G. Inhalation of nitric oxide modulates adult human bronchial tone. Am Rev Respir Dis. 1993 Dec;148(6 Pt 1):1474–1478. doi: 10.1164/ajrccm/148.6_Pt_1.1474. [DOI] [PubMed] [Google Scholar]
  21. Ignarro L. J., Buga G. M., Wood K. S., Byrns R. E., Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9265–9269. doi: 10.1073/pnas.84.24.9265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Katayama Y., Higenbottam T. W., Diaz de Atauri M. J., Cremona G., Akamine S., Barbera J. A., Rodrìguez-Roisin R. Inhaled nitric oxide and arterial oxygen tension in patients with chronic obstructive pulmonary disease and severe pulmonary hypertension. Thorax. 1997 Feb;52(2):120–124. doi: 10.1136/thx.52.2.120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Knowles R. G., Moncada S. Nitric oxide synthases in mammals. Biochem J. 1994 Mar 1;298(Pt 2):249–258. doi: 10.1042/bj2980249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. MacNee W. Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease. Part two. Am J Respir Crit Care Med. 1994 Oct;150(4):1158–1168. doi: 10.1164/ajrccm.150.4.7921453. [DOI] [PubMed] [Google Scholar]
  25. Melot C., Hallemans R., Naeije R., Mols P., Lejeune P. Deleterious effect of nifedipine on pulmonary gas exchange in chronic obstructive pulmonary disease. Am Rev Respir Dis. 1984 Oct;130(4):612–616. doi: 10.1164/arrd.1984.130.4.612. [DOI] [PubMed] [Google Scholar]
  26. Moinard J., Manier G., Pillet O., Castaing Y. Effect of inhaled nitric oxide on hemodynamics and VA/Q inequalities in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1994 Jun;149(6):1482–1487. doi: 10.1164/ajrccm.149.6.8004302. [DOI] [PubMed] [Google Scholar]
  27. Moncada S., Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993 Dec 30;329(27):2002–2012. doi: 10.1056/NEJM199312303292706. [DOI] [PubMed] [Google Scholar]
  28. Moncada S., Palmer R. M., Higgs E. A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991 Jun;43(2):109–142. [PubMed] [Google Scholar]
  29. Mélot C., Naeije R., Rothschild T., Mertens P., Mols P., Hallemans R. Improvement in ventilation-perfusion matching by almitrine in COPD. Chest. 1983 Mar;83(3):528–533. doi: 10.1378/chest.83.3.528. [DOI] [PubMed] [Google Scholar]
  30. Naeije R., Mélot C., Mols P., Hallemans R., Naeije N., Cornil A., Sergysels R. Effects of almitrine in decompensated chronic respiratory insufficiency. Bull Eur Physiopathol Respir. 1981;17(2):153–161. [PubMed] [Google Scholar]
  31. Neonatal Inhaled Nitric Oxide Study Group Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med. 1997 Feb 27;336(9):597–604. doi: 10.1056/NEJM199702273360901. [DOI] [PubMed] [Google Scholar]
  32. Palmer R. M., Ferrige A. G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987 Jun 11;327(6122):524–526. doi: 10.1038/327524a0. [DOI] [PubMed] [Google Scholar]
  33. Pepke-Zaba J., Higenbottam T. W., Dinh-Xuan A. T., Stone D., Wallwork J. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet. 1991 Nov 9;338(8776):1173–1174. doi: 10.1016/0140-6736(91)92033-x. [DOI] [PubMed] [Google Scholar]
  34. Pison U., López F. A., Heidelmeyer C. F., Rossaint R., Falke K. J. Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction without impairing gas exchange. J Appl Physiol (1985) 1993 Mar;74(3):1287–1292. doi: 10.1152/jappl.1993.74.3.1287. [DOI] [PubMed] [Google Scholar]
  35. Roberts J. D., Jr, Lang P., Bigatello L. M., Vlahakes G. J., Zapol W. M. Inhaled nitric oxide in congenital heart disease. Circulation. 1993 Feb;87(2):447–453. doi: 10.1161/01.cir.87.2.447. [DOI] [PubMed] [Google Scholar]
  36. Roberts J. D., Polaner D. M., Lang P., Zapol W. M. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 1992 Oct 3;340(8823):818–819. doi: 10.1016/0140-6736(92)92686-a. [DOI] [PubMed] [Google Scholar]
  37. Roca J., Wagner P. D. Contribution of multiple inert gas elimination technique to pulmonary medicine. 1. Principles and information content of the multiple inert gas elimination technique. Thorax. 1994 Aug;49(8):815–824. doi: 10.1136/thx.49.8.815. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Rossaint R., Falke K. J., López F., Slama K., Pison U., Zapol W. M. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med. 1993 Feb 11;328(6):399–405. doi: 10.1056/NEJM199302113280605. [DOI] [PubMed] [Google Scholar]
  39. Torres A., Reyes A., Roca J., Wagner P. D., Rodriguez-Roisin R. Ventilation-perfusion mismatching in chronic obstructive pulmonary disease during ventilator weaning. Am Rev Respir Dis. 1989 Nov;140(5):1246–1250. doi: 10.1164/ajrccm/140.5.1246. [DOI] [PubMed] [Google Scholar]
  40. Voelkel N. F. Mechanisms of hypoxic pulmonary vasoconstriction. Am Rev Respir Dis. 1986 Jun;133(6):1186–1195. doi: 10.1164/arrd.1986.133.6.1186. [DOI] [PubMed] [Google Scholar]
  41. Wagner P. D., Dantzker D. R., Dueck R., Clausen J. L., West J. B. Ventilation-perfusion inequality in chronic obstructive pulmonary disease. J Clin Invest. 1977 Feb;59(2):203–216. doi: 10.1172/JCI108630. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Walmrath D., Schneider T., Pilch J., Schermuly R., Grimminger F., Seeger W. Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis. Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):724–730. doi: 10.1164/ajrccm.151.3.7881662. [DOI] [PubMed] [Google Scholar]
  43. Weir E. K., Archer S. L. The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J. 1995 Feb;9(2):183–189. doi: 10.1096/fasebj.9.2.7781921. [DOI] [PubMed] [Google Scholar]
  44. Weitzenblum E., Hirth C., Ducolone A., Mirhom R., Rasaholinjanahary J., Ehrhart M. Prognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease. Thorax. 1981 Oct;36(10):752–758. doi: 10.1136/thx.36.10.752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Weitzenblum E., Hirth C., Ducolone A., Mirhom R., Rasaholinjanahary J., Ehrhart M. Prognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease. Thorax. 1981 Oct;36(10):752–758. doi: 10.1136/thx.36.10.752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Weitzenblum E., Kessler R., Oswald M., Fraisse P. Medical treatment of pulmonary hypertension in chronic lung disease. Eur Respir J. 1994 Jan;7(1):148–152. doi: 10.1183/09031936.94.07010148. [DOI] [PubMed] [Google Scholar]
  47. Weitzenblum E., Sautegeau A., Ehrhart M., Mammosser M., Pelletier A. Long-term oxygen therapy can reverse the progression of pulmonary hypertension in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1985 Apr;131(4):493–498. doi: 10.1164/arrd.1985.131.4.493. [DOI] [PubMed] [Google Scholar]
  48. Weitzenblum E., Schrijen F., Apprill M., Prefaut C., Yernault J. C. One year treatment with almitrine improves hypoxaemia but does not increase pulmonary artery pressure in COPD patients. Eur Respir J. 1991 Nov;4(10):1215–1222. [PubMed] [Google Scholar]
  49. Wysocki M., Delclaux C., Roupie E., Langeron O., Liu N., Herman B., Lemaire F., Brochard L. Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome. Intensive Care Med. 1994;20(4):254–259. doi: 10.1007/BF01708960. [DOI] [PubMed] [Google Scholar]

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