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. 1998 Aug;53(Suppl 2):S3–S9. doi: 10.1136/thx.53.2008.s3

In search of a cause of cryptogenic fibrosing alveolitis (CFA): one initiating factor or many?

M Turner-Warwick
PMCID: PMC1765900  PMID: 10193340

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Selected References

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  1. Baumgartner K. B., Samet J. M., Stidley C. A., Colby T. V., Waldron J. A. Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1997 Jan;155(1):242–248. doi: 10.1164/ajrccm.155.1.9001319. [DOI] [PubMed] [Google Scholar]
  2. Briggs D. C., Vaughan R. W., Welsh K. I., Myers A., duBois R. M., Black C. M. Immunogenetic prediction of pulmonary fibrosis in systemic sclerosis. Lancet. 1991 Sep 14;338(8768):661–662. doi: 10.1016/0140-6736(91)91235-m. [DOI] [PubMed] [Google Scholar]
  3. Chapman J. R., Charles P. J., Venables P. J., Thompson P. J., Haslam P. L., Maini R. N., Turner Warwick M. E. Definition and clinical relevance of antibodies to nuclear ribonucleoprotein and other nuclear antigens in patients with cryptogenic fibrosing alveolitis. Am Rev Respir Dis. 1984 Sep;130(3):439–443. doi: 10.1164/arrd.1984.130.3.439. [DOI] [PubMed] [Google Scholar]
  4. Coates E. O., Jr, Watson J. H. Diffuse interstitial lung disease in tungsten carbide workers. Ann Intern Med. 1971 Nov;75(5):709–716. doi: 10.7326/0003-4819-75-5-709. [DOI] [PubMed] [Google Scholar]
  5. Corrin B., Dewar A. Pathogenesis of idiopathic interstitial pulmonary fibrosis. Ultrastruct Pathol. 1996 Jul-Aug;20(4):369–371. doi: 10.3109/01913129609016339. [DOI] [PubMed] [Google Scholar]
  6. Egan J. J., Stewart J. P., Hasleton P. S., Arrand J. R., Carroll K. B., Woodcock A. A. Epstein-Barr virus replication within pulmonary epithelial cells in cryptogenic fibrosing alveolitis. Thorax. 1995 Dec;50(12):1234–1239. doi: 10.1136/thx.50.12.1234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Egan J. J., Woodcock A. A., Stewart J. P. Viruses and idiopathic pulmonary fibrosis. Eur Respir J. 1997 Jul;10(7):1433–1437. doi: 10.1183/09031936.97.10071433. [DOI] [PubMed] [Google Scholar]
  8. Gaensler E. A., Cadigan J. B., Sasahara A. A., Fox E. O., MacMahon H. E. Graphite pneumoconiosis of electrotypers. Am J Med. 1966 Dec;41(6):864–882. doi: 10.1016/0002-9343(66)90046-5. [DOI] [PubMed] [Google Scholar]
  9. Harrison N. K., Myers A. R., Corrin B., Soosay G., Dewar A., Black C. M., Du Bois R. M., Turner-Warwick M. Structural features of interstitial lung disease in systemic sclerosis. Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):706–713. doi: 10.1164/ajrccm/144.3_Pt_1.706. [DOI] [PubMed] [Google Scholar]
  10. Hubbard R., Lewis S., Richards K., Johnston I., Britton J. Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis. Lancet. 1996 Feb 3;347(8997):284–289. doi: 10.1016/s0140-6736(96)90465-1. [DOI] [PubMed] [Google Scholar]
  11. Iwai K., Mori T., Yamada N., Yamaguchi M., Hosoda Y. Idiopathic pulmonary fibrosis. Epidemiologic approaches to occupational exposure. Am J Respir Crit Care Med. 1994 Sep;150(3):670–675. doi: 10.1164/ajrccm.150.3.8087336. [DOI] [PubMed] [Google Scholar]
  12. Johnson M. A., Kwan S., Snell N. J., Nunn A. J., Darbyshire J. H., Turner-Warwick M. Randomised controlled trial comparing prednisolone alone with cyclophosphamide and low dose prednisolone in combination in cryptogenic fibrosing alveolitis. Thorax. 1989 Apr;44(4):280–288. doi: 10.1136/thx.44.4.280. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Johnson N. F., Haslam P. L., Dewar A., Newman-Taylor A. J., Turner-Warwick M. Identification of inorganic dust particles in bronchoalveolar lavage macrophages by energy dispersive x-ray microanalysis. Arch Environ Health. 1986 May-Jun;41(3):133–144. doi: 10.1080/00039896.1986.9935767. [DOI] [PubMed] [Google Scholar]
  14. Libby D. M., Gibofsky A., Fotino M., Waters S. J., Smith J. P. Immunogenetic and clinical findings in idiopathic pulmonary fibrosis. Association with the B-cell alloantigen HLA-DR2. Am Rev Respir Dis. 1983 May;127(5):618–622. doi: 10.1164/arrd.1983.127.5.618. [DOI] [PubMed] [Google Scholar]
  15. Liebow A. A., Carrington C. B. Diffuse pulmonary lymphoreticular infiltrations associated with dysproteinemia. Med Clin North Am. 1973 May;57(3):809–843. doi: 10.1016/s0025-7125(16)32278-7. [DOI] [PubMed] [Google Scholar]
  16. Lympany P. A., du Bois R. M. Diffuse lung disease: product of genetic susceptibility and environmental encounters. Thorax. 1997 Jan;52(1):92–94. doi: 10.1136/thx.52.1.92. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Lympany P. A., du Bois R. M. Interstitial lung disease: basic mechanisms and genetic predisposition. Monaldi Arch Chest Dis. 1997 Feb;52(1):33–36. [PubMed] [Google Scholar]
  18. RICHARDS R. L., MILNE J. A. Cancer of the lung in progressive systemic sclerosis. Thorax. 1958 Sep;13(3):238–245. doi: 10.1136/thx.13.3.238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Remy-Jardin M., Giraud F., Remy J., Copin M. C., Gosselin B., Duhamel A. Importance of ground-glass attenuation in chronic diffuse infiltrative lung disease: pathologic-CT correlation. Radiology. 1993 Dec;189(3):693–698. doi: 10.1148/radiology.189.3.8234692. [DOI] [PubMed] [Google Scholar]
  20. SCADDING J. G. FIBROSING ALVEOLITIS. Br Med J. 1964 Sep 12;2(5410):686–686. doi: 10.1136/bmj.2.5410.686. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Schwartz D. A., Helmers R. A., Dayton C. S., Merchant R. K., Hunninghake G. W. Determinants of bronchoalveolar lavage cellularity in idiopathic pulmonary fibrosis. J Appl Physiol (1985) 1991 Nov;71(5):1688–1693. doi: 10.1152/jappl.1991.71.5.1688. [DOI] [PubMed] [Google Scholar]
  22. Scott J., Johnston I., Britton J. What causes cryptogenic fibrosing alveolitis? A case-control study of environmental exposure to dust. BMJ. 1990 Nov 3;301(6759):1015–1017. doi: 10.1136/bmj.301.6759.1015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Steers G., McMahon M. J., Grennan D. M., Hillarby M. C. Lack of association of the alpha-1-antitrypsin PIZ allele with rheumatoid arthritis or with its extra articular complications. Dis Markers. 1992 May-Jun;10(3):151–157. [PubMed] [Google Scholar]
  24. TURNER-WARWICK M., DONIACH D. AUTO-ANTIBODY STUDIES IN INTERSTITIAL PULMONARY FIBROSIS. Br Med J. 1965 Apr 3;1(5439):886–891. doi: 10.1136/bmj.1.5439.886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. TURNER-WARWICK M. SYSTEMIC ARTERIAL PATTERNS IN THE LUNG AND CLUBBING OF THE FINGERS. Thorax. 1963 Sep;18:238–250. doi: 10.1136/thx.18.3.238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. TURNER-WARWICK M. SYSTEMIC ARTERIAL PATTERNS IN THE LUNG AND CLUBBING OF THE FINGERS. Thorax. 1963 Sep;18:238–250. doi: 10.1136/thx.18.3.238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Takahashi T., Munakata M., Takekawa H., Homma Y., Kawakami Y. Pulmonary fibrosis in a carpenter with long-lasting exposure to fiberglass. Am J Ind Med. 1996 Nov;30(5):596–600. doi: 10.1002/(SICI)1097-0274(199611)30:5<596::AID-AJIM7>3.0.CO;2-R. [DOI] [PubMed] [Google Scholar]
  28. Turner-Warwick M., Burrows B., Johnson A. Cryptogenic fibrosing alveolitis: clinical features and their influence on survival. Thorax. 1980 Mar;35(3):171–180. doi: 10.1136/thx.35.3.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Turner-Warwick M., Burrows B., Johnson A. Cryptogenic fibrosing alveolitis: response to corticosteroid treatment and its effect on survival. Thorax. 1980 Aug;35(8):593–599. doi: 10.1136/thx.35.8.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Turner-Warwick M., Lebowitz M., Burrows B., Johnson A. Cryptogenic fibrosing alveolitis and lung cancer. Thorax. 1980 Jul;35(7):496–499. doi: 10.1136/thx.35.7.496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Vergnon J. M., Vincent M., de Thé G., Mornex J. F., Weynants P., Brune J. Cryptogenic fibrosing alveolitis and Epstein-Barr virus: an association? Lancet. 1984 Oct 6;2(8406):768–771. doi: 10.1016/s0140-6736(84)90702-5. [DOI] [PubMed] [Google Scholar]
  32. Wallace W. A., Schofield J. A., Lamb D., Howie S. E. Localisation of a pulmonary autoantigen in cryptogenic fibrosing alveolitis. Thorax. 1994 Nov;49(11):1139–1145. doi: 10.1136/thx.49.11.1139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Wells A. U., Cullinan P., Hansell D. M., Rubens M. B., Black C. M., Newman-Taylor A. J., Du Bois R. M. Fibrosing alveolitis associated with systemic sclerosis has a better prognosis than lone cryptogenic fibrosing alveolitis. Am J Respir Crit Care Med. 1994 Jun;149(6):1583–1590. doi: 10.1164/ajrccm.149.6.8004317. [DOI] [PubMed] [Google Scholar]
  34. Wells A. U., Hansell D. M., Harrison N. K., Lawrence R., Black C. M., du Bois R. M. Clearance of inhaled 99mTc-DTPA predicts the clinical course of fibrosing alveolitis. Eur Respir J. 1993 Jun;6(6):797–802. [PubMed] [Google Scholar]
  35. Wells A. U., Rubens M. B., du Bois R. M., Hansell D. M. Serial CT in fibrosing alveolitis: prognostic significance of the initial pattern. AJR Am J Roentgenol. 1993 Dec;161(6):1159–1165. doi: 10.2214/ajr.161.6.8249719. [DOI] [PubMed] [Google Scholar]
  36. de Cremoux H., Bernaudin J. F., Laurent P., Brochard P., Bignon J. Interactions between cigarette smoking and the natural history of idiopathic pulmonary fibrosis. Chest. 1990 Jul;98(1):71–76. doi: 10.1378/chest.98.1.71. [DOI] [PubMed] [Google Scholar]

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