Skip to main content
Thorax logoLink to Thorax
. 2000 Oct;55(Suppl 2):S32–S37. doi: 10.1136/thorax.55.suppl_2.S32

Role of leukotrienes in bronchial hyperresponsiveness and cellular responses in airways

A Leff
PMCID: PMC1765960  PMID: 10992554

Full Text

The Full Text of this article is available as a PDF (213.0 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albelda S. M., Buck C. A. Integrins and other cell adhesion molecules. FASEB J. 1990 Aug;4(11):2868–2880. [PubMed] [Google Scholar]
  2. Albelda S. M. Endothelial and epithelial cell adhesion molecules. Am J Respir Cell Mol Biol. 1991 Mar;4(3):195–203. doi: 10.1165/ajrcmb/4.3.195. [DOI] [PubMed] [Google Scholar]
  3. Bevilacqua M. P., Stengelin S., Gimbrone M. A., Jr, Seed B. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science. 1989 Mar 3;243(4895):1160–1165. doi: 10.1126/science.2466335. [DOI] [PubMed] [Google Scholar]
  4. Calhoun W. J., Lavins B. J., Minkwitz M. C., Evans R., Gleich G. J., Cohn J. Effect of zafirlukast (Accolate) on cellular mediators of inflammation: bronchoalveolar lavage fluid findings after segmental antigen challenge. Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1381–1389. doi: 10.1164/ajrccm.157.5.9609014. [DOI] [PubMed] [Google Scholar]
  5. Diamant Z., Hiltermann J. T., van Rensen E. L., Callenbach P. M., Veselic-Charvat M., van der Veen H., Sont J. K., Sterk P. J. The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. Am J Respir Crit Care Med. 1997 Apr;155(4):1247–1253. doi: 10.1164/ajrccm.155.4.9105062. [DOI] [PubMed] [Google Scholar]
  6. Galens S., Muñoz N. M., Rabe K. F., Herrnreiter A., Mayer D., Morton B., McAllister K., Leff A. R. Assessment of agonist- and cell-mediated responses in airway microsections by computerized videomicrometry. Am J Physiol. 1995 Mar;268(3 Pt 1):L519–L525. doi: 10.1152/ajplung.1995.268.3.L519. [DOI] [PubMed] [Google Scholar]
  7. Gleich G. J. The eosinophil and bronchial asthma: current understanding. J Allergy Clin Immunol. 1990 Feb;85(2):422–436. doi: 10.1016/0091-6749(90)90151-s. [DOI] [PubMed] [Google Scholar]
  8. Hamann K. J., Strek M. E., Baranowski S. L., Munoz N. M., Williams F. S., White S. R., Vita A., Leff A. R. Effects of activated eosinophils cultured from human umbilical cord blood on guinea pig trachealis. Am J Physiol. 1993 Sep;265(3 Pt 1):L301–L307. doi: 10.1152/ajplung.1993.265.3.L301. [DOI] [PubMed] [Google Scholar]
  9. Jackson W. T., Boyd R. J., Froelich L. L., Mallett B. E., Gapinski D. M. Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. J Pharmacol Exp Ther. 1992 Dec;263(3):1009–1014. [PubMed] [Google Scholar]
  10. Jaraquemada D., Martin R., Rosen-Bronson S., Flerlage M., McFarland H. F., Long E. O. HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals. J Immunol. 1990 Nov 1;145(9):2880–2885. [PubMed] [Google Scholar]
  11. Jeffery P. K., Wardlaw A. J., Nelson F. C., Collins J. V., Kay A. B. Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis. 1989 Dec;140(6):1745–1753. doi: 10.1164/ajrccm/140.6.1745. [DOI] [PubMed] [Google Scholar]
  12. Kishikawa K., Tateishi N., Maruyama T., Seo R., Toda M., Miyamoto T. ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261–275. doi: 10.1016/0090-6980(92)90002-b. [DOI] [PubMed] [Google Scholar]
  13. Leff A. R., Hamann K. J., Wegner C. D. Inflammation and cell-cell interactions in airway hyperresponsiveness. Am J Physiol. 1991 Apr;260(4 Pt 1):L189–L206. doi: 10.1152/ajplung.1991.260.4.L189. [DOI] [PubMed] [Google Scholar]
  14. Leff A. R. Inflammatory mediation of airway hyperresponsiveness by peripheral blood granulocytes. The case for the eosinophil. Chest. 1994 Oct;106(4):1202–1208. doi: 10.1378/chest.106.4.1202. [DOI] [PubMed] [Google Scholar]
  15. Mitchell R. W., Rühlmann E., Magnussen H., Leff A. R., Rabe K. F. Passive sensitization of human bronchi augments smooth muscle shortening velocity and capacity. Am J Physiol. 1994 Aug;267(2 Pt 1):L218–L222. doi: 10.1152/ajplung.1994.267.2.L218. [DOI] [PubMed] [Google Scholar]
  16. Munoz N. M., Hamann K. J., Vita A., Cozzi P. J., Baranowski S., Solway J., Leff A. R. Activation of tracheal smooth muscle responsiveness by fMLP-treated HL-60 cells and neutrophils. Am J Physiol. 1993 Mar;264(3 Pt 1):L222–L228. doi: 10.1152/ajplung.1993.264.3.L222. [DOI] [PubMed] [Google Scholar]
  17. Muñoz N. M., Douglas I., Mayer D., Herrnreiter A., Zhu X., Leff A. R. Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. Am J Respir Crit Care Med. 1997 Apr;155(4):1398–1403. doi: 10.1164/ajrccm.155.4.9105085. [DOI] [PubMed] [Google Scholar]
  18. Muñoz N. M., Rabe K. F., Neeley S. P., Herrnreiter A., Zhu X., McAllister K., Mayer D., Magnussen H., Galens S., Leff A. R. Eosinophil VLA-4 binding to fibronectin augments bronchial narrowing through 5-lipoxygenase activation. Am J Physiol. 1996 Apr;270(4 Pt 1):L587–L594. doi: 10.1152/ajplung.1996.270.4.L587. [DOI] [PubMed] [Google Scholar]
  19. Neeley S. P., Hamann K. J., Dowling T. L., McAllister K. T., White S. R., Leff A. R. Augmentation of stimulated eosinophil degranulation by VLA-4 (CD49d)-mediated adhesion to fibronectin. Am J Respir Cell Mol Biol. 1994 Aug;11(2):206–213. doi: 10.1165/ajrcmb.11.2.8049081. [DOI] [PubMed] [Google Scholar]
  20. Padrid P., Snook S., Finucane T., Shiue P., Cozzi P., Solway J., Leff A. R. Persistent airway hyperresponsiveness and histologic alterations after chronic antigen challenge in cats. Am J Respir Crit Care Med. 1995 Jan;151(1):184–193. doi: 10.1164/ajrccm.151.1.7812551. [DOI] [PubMed] [Google Scholar]
  21. Padrid P., Wolf R., Munoz N. M., Spaethe S., Finucane T., Solway J., Leff A. R. Augmented muscarinic responsiveness caused by 5-lipoxygenase products secreted from alveolar macrophages in isolated-perfused rat lung. Am Rev Respir Dis. 1993 Jun;147(6 Pt 1):1514–1520. doi: 10.1164/ajrccm/147.6_Pt_1.1514. [DOI] [PubMed] [Google Scholar]
  22. Schmidt D., Rabe K. F. The role of leukotrienes in the regulation of tone and responsiveness in isolated human airways. Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 2):S62–S67. doi: 10.1164/ajrccm.161.supplement_1.ltta-13. [DOI] [PubMed] [Google Scholar]
  23. Silbaugh S. A., Stengel P. W., Williams G. D., Herron D. K., Gallagher P., Baker S. R. Effects of leukotriene B4 inhalation. Airway sensitization and lung granulocyte infiltration in the guinea pig. Am Rev Respir Dis. 1987 Oct;136(4):930–934. doi: 10.1164/ajrccm/136.4.930. [DOI] [PubMed] [Google Scholar]
  24. Underwood D. C., Osborn R. R., Newsholme S. J., Torphy T. J., Hay D. W. Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody. Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):850–857. doi: 10.1164/ajrccm.154.4.8887574. [DOI] [PubMed] [Google Scholar]
  25. Wegner C. D., Gundel R. H., Reilly P., Haynes N., Letts L. G., Rothlein R. Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma. Science. 1990 Jan 26;247(4941):456–459. doi: 10.1126/science.1967851. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES