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. 2000 Oct;55(Suppl 2):S51–S53. doi: 10.1136/thorax.55.suppl_2.S51

Oxidant stress in asthma

R Dworski
PMCID: PMC1765968  PMID: 10992559

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Selected References

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  1. Antczak A., Nowak D., Shariati B., Król M., Piasecka G., Kurmanowska Z. Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients. Eur Respir J. 1997 Jun;10(6):1235–1241. doi: 10.1183/09031936.97.10061235. [DOI] [PubMed] [Google Scholar]
  2. Baker J. C., Tunnicliffe W. S., Duncanson R. C., Ayres J. G. Dietary antioxidants and magnesium in type 1 brittle asthma: a case control study. Thorax. 1999 Feb;54(2):115–118. doi: 10.1136/thx.54.2.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bodner C., Godden D., Brown K., Little J., Ross S., Seaton A. Antioxidant intake and adult-onset wheeze: a case-control study. Aberdeen WHEASE Study Group. Eur Respir J. 1999 Jan;13(1):22–30. doi: 10.1183/09031936.99.13102299. [DOI] [PubMed] [Google Scholar]
  4. Bozeman P. M., Learn D. B., Thomas E. L. Assay of the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase. J Immunol Methods. 1990 Jan 24;126(1):125–133. doi: 10.1016/0022-1759(90)90020-v. [DOI] [PubMed] [Google Scholar]
  5. Bruynzeel P. L., Koenderman L., Kok P. T., Hameling M. L., Verhagen J. Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils. Pharmacol Res Commun. 1986 Aug;18 (Suppl):61–69. doi: 10.1016/0031-6989(86)90039-1. [DOI] [PubMed] [Google Scholar]
  6. Calhoun W. J., Reed H. E., Moest D. R., Stevens C. A. Enhanced superoxide production by alveolar macrophages and air-space cells, airway inflammation, and alveolar macrophage density changes after segmental antigen bronchoprovocation in allergic subjects. Am Rev Respir Dis. 1992 Feb;145(2 Pt 1):317–325. doi: 10.1164/ajrccm/145.2_Pt_1.317. [DOI] [PubMed] [Google Scholar]
  7. Chihara J., Hayashi N., Kakazu T., Yamamoto T., Kurachi D., Nakajima S. RANTES augments radical oxygen products from eosinophils. Int Arch Allergy Immunol. 1994;104 (Suppl 1)(1):52–53. doi: 10.1159/000236752. [DOI] [PubMed] [Google Scholar]
  8. Cluzel M., Damon M., Chanez P., Bousquet J., Crastes de Paulet A., Michel F. B., Godard P. Enhanced alveolar cell luminol-dependent chemiluminescence in asthma. J Allergy Clin Immunol. 1987 Aug;80(2):195–201. doi: 10.1016/0091-6749(87)90129-1. [DOI] [PubMed] [Google Scholar]
  9. Cortijo J., Martí-Cabrera M., de la Asuncíon J. G., Pallardó F. V., Esteras A., Bruseghini L., Viña J., Morcillo E. J. Contraction of human airways by oxidative stress protection by N-acetylcysteine. Free Radic Biol Med. 1999 Aug;27(3-4):392–400. doi: 10.1016/s0891-5849(99)00070-2. [DOI] [PubMed] [Google Scholar]
  10. DeForge L. E., Preston A. M., Takeuchi E., Kenney J., Boxer L. A., Remick D. G. Regulation of interleukin 8 gene expression by oxidant stress. J Biol Chem. 1993 Dec 5;268(34):25568–25576. [PubMed] [Google Scholar]
  11. Dohlman A. W., Black H. R., Royall J. A. Expired breath hydrogen peroxide is a marker of acute airway inflammation in pediatric patients with asthma. Am Rev Respir Dis. 1993 Oct;148(4 Pt 1):955–960. doi: 10.1164/ajrccm/148.4_Pt_1.955. [DOI] [PubMed] [Google Scholar]
  12. Dworski R., Murray J. J., Roberts L. J., 2nd, Oates J. A., Morrow J. D., Fisher L., Sheller J. R. Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am J Respir Crit Care Med. 1999 Dec;160(6):1947–1951. doi: 10.1164/ajrccm.160.6.9903064. [DOI] [PubMed] [Google Scholar]
  13. Feng L., Xia Y., Garcia G. E., Hwang D., Wilson C. B. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide. J Clin Invest. 1995 Apr;95(4):1669–1675. doi: 10.1172/JCI117842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Flatt A., Pearce N., Thomson C. D., Sears M. R., Robinson M. F., Beasley R. Reduced selenium in asthmatic subjects in New Zealand. Thorax. 1990 Feb;45(2):95–99. doi: 10.1136/thx.45.2.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Grievink L., Smit H. A., Ocké M. C., van 't Veer P., Kromhout D. Dietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the MORGEN study. Thorax. 1998 Mar;53(3):166–171. doi: 10.1136/thx.53.3.166. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Halliwell B. Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med. 1991 Sep 30;91(3C):14S–22S. doi: 10.1016/0002-9343(91)90279-7. [DOI] [PubMed] [Google Scholar]
  17. Health effects of outdoor air pollution. Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society. Am J Respir Crit Care Med. 1996 Jan;153(1):3–50. doi: 10.1164/ajrccm.153.1.8542133. [DOI] [PubMed] [Google Scholar]
  18. Hulsmann A. R., Raatgeep H. R., den Hollander J. C., Stijnen T., Saxena P. R., Kerrebijn K. F., de Jongste J. C. Oxidative epithelial damage produces hyperresponsiveness of human peripheral airways. Am J Respir Crit Care Med. 1994 Feb;149(2 Pt 1):519–525. doi: 10.1164/ajrccm.149.2.8306055. [DOI] [PubMed] [Google Scholar]
  19. Jarjour N. N., Busse W. W., Calhoun W. J. Enhanced production of oxygen radicals in nocturnal asthma. Am Rev Respir Dis. 1992 Oct;146(4):905–911. doi: 10.1164/ajrccm/146.4.905. [DOI] [PubMed] [Google Scholar]
  20. Kanazawa H., Kurihara N., Hirata K., Takeda T. The role of free radicals in airway obstruction in asthmatic patients. Chest. 1991 Nov;100(5):1319–1322. doi: 10.1378/chest.100.5.1319. [DOI] [PubMed] [Google Scholar]
  21. Kharitonov S. A., Yates D., Robbins R. A., Logan-Sinclair R., Shinebourne E. A., Barnes P. J. Increased nitric oxide in exhaled air of asthmatic patients. Lancet. 1994 Jan 15;343(8890):133–135. doi: 10.1016/s0140-6736(94)90931-8. [DOI] [PubMed] [Google Scholar]
  22. Kourie J. I. Interaction of reactive oxygen species with ion transport mechanisms. Am J Physiol. 1998 Jul;275(1 Pt 1):C1–24. doi: 10.1152/ajpcell.1998.275.1.C1. [DOI] [PubMed] [Google Scholar]
  23. Landino L. M., Crews B. C., Timmons M. D., Morrow J. D., Marnett L. J. Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15069–15074. doi: 10.1073/pnas.93.26.15069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Leonarduzzi G., Scavazza A., Biasi F., Chiarpotto E., Camandola S., Vogel S., Dargel R., Poli G. The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis. FASEB J. 1997 Sep;11(11):851–857. doi: 10.1096/fasebj.11.11.9285483. [DOI] [PubMed] [Google Scholar]
  25. McCormick M. L., Roeder T. L., Railsback M. A., Britigan B. E. Eosinophil peroxidase-dependent hydroxyl radical generation by human eosinophils. J Biol Chem. 1994 Nov 11;269(45):27914–27919. [PubMed] [Google Scholar]
  26. Misso N. L., Powers K. A., Gillon R. L., Stewart G. A., Thompson P. J. Reduced platelet glutathione peroxidase activity and serum selenium concentration in atopic asthmatic patients. Clin Exp Allergy. 1996 Jul;26(7):838–847. [PubMed] [Google Scholar]
  27. Morrow J. D., Roberts L. J. The isoprostanes: unique bioactive products of lipid peroxidation. Prog Lipid Res. 1997 Mar;36(1):1–21. doi: 10.1016/s0163-7827(97)00001-5. [DOI] [PubMed] [Google Scholar]
  28. Morrow J. D., Zackert W. E., Yang J. P., Kurhts E. H., Callewaert D., Dworski R., Kanai K., Taber D., Moore K., Oates J. A. Quantification of the major urinary metabolite of 15-F2t-isoprostane (8-iso-PGF2alpha) by a stable isotope dilution mass spectrometric assay. Anal Biochem. 1999 May 1;269(2):326–331. doi: 10.1006/abio.1999.4008. [DOI] [PubMed] [Google Scholar]
  29. Nagata M., Sedgwick J. B., Vrtis R., Busse W. W. Endothelial cells upregulate eosinophil superoxide generation via VCAM-1 expression. Clin Exp Allergy. 1999 Apr;29(4):550–561. doi: 10.1046/j.1365-2222.1999.00506.x. [DOI] [PubMed] [Google Scholar]
  30. Okamoto K., Tanaka H., Ogawa H., Makino Y., Eguchi H., Hayashi S., Yoshikawa N., Poellinger L., Umesono K., Makino I. Redox-dependent regulation of nuclear import of the glucocorticoid receptor. J Biol Chem. 1999 Apr 9;274(15):10363–10371. doi: 10.1074/jbc.274.15.10363. [DOI] [PubMed] [Google Scholar]
  31. Olopade C. O., Zakkar M., Swedler W. I., Rubinstein I. Exhaled pentane levels in acute asthma. Chest. 1997 Apr;111(4):862–865. doi: 10.1378/chest.111.4.862. [DOI] [PubMed] [Google Scholar]
  32. Owen S., Pearson D., Suarez-Mendez V., O'Driscoll R., Woodcock A. Evidence of free-radical activity in asthma. N Engl J Med. 1991 Aug 22;325(8):586–587. doi: 10.1056/NEJM199108223250816. [DOI] [PubMed] [Google Scholar]
  33. Ramos C. L., Pou S., Britigan B. E., Cohen M. S., Rosen G. M. Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes. J Biol Chem. 1992 Apr 25;267(12):8307–8312. [PubMed] [Google Scholar]
  34. Rankin J. A., Harris P., Ackerman S. J. The effects of eosinophil-granule major basic protein on lung-macrophage superoxide anion generation. J Allergy Clin Immunol. 1992 Mar;89(3):746–752. doi: 10.1016/0091-6749(92)90383-d. [DOI] [PubMed] [Google Scholar]
  35. Rashba-Step J., Tatoyan A., Duncan R., Ann D., Pushpa-Rehka T. R., Sevanian A. Phospholipid peroxidation induces cytosolic phospholipase A2 activity: membrane effects versus enzyme phosphorylation. Arch Biochem Biophys. 1997 Jul 1;343(1):44–54. doi: 10.1006/abbi.1997.0134. [DOI] [PubMed] [Google Scholar]
  36. Rochelle L. G., Fischer B. M., Adler K. B. Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro. Free Radic Biol Med. 1998 Mar 15;24(5):863–868. doi: 10.1016/s0891-5849(97)00375-4. [DOI] [PubMed] [Google Scholar]
  37. Sadeghi-Hashjin G., Folkerts G., Henricks P. A., Verheyen A. K., van der Linde H. J., van Ark I., Coene A., Nijkamp F. P. Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo. Am J Respir Crit Care Med. 1996 May;153(5):1697–1701. doi: 10.1164/ajrccm.153.5.8630623. [DOI] [PubMed] [Google Scholar]
  38. Saleh D., Ernst P., Lim S., Barnes P. J., Giaid A. Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid. FASEB J. 1998 Aug;12(11):929–937. [PubMed] [Google Scholar]
  39. Sanders S. P., Zweier J. L., Harrison S. J., Trush M. A., Rembish S. J., Liu M. C. Spontaneous oxygen radical production at sites of antigen challenge in allergic subjects. Am J Respir Crit Care Med. 1995 Jun;151(6):1725–1733. doi: 10.1164/ajrccm.151.6.7767513. [DOI] [PubMed] [Google Scholar]
  40. Schreck R., Rieber P., Baeuerle P. A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J. 1991 Aug;10(8):2247–2258. doi: 10.1002/j.1460-2075.1991.tb07761.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Sedgwick J. B., Geiger K. M., Busse W. W. Superoxide generation by hypodense eosinophils from patients with asthma. Am Rev Respir Dis. 1990 Jul;142(1):120–125. doi: 10.1164/ajrccm/142.1.120. [DOI] [PubMed] [Google Scholar]
  42. Simon A. R., Rai U., Fanburg B. L., Cochran B. H. Activation of the JAK-STAT pathway by reactive oxygen species. Am J Physiol. 1998 Dec;275(6 Pt 1):C1640–C1652. doi: 10.1152/ajpcell.1998.275.6.C1640. [DOI] [PubMed] [Google Scholar]
  43. Slungaard A., Vercellotti G. M., Walker G., Nelson R. D., Jacob H. S. Tumor necrosis factor alpha/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium. J Exp Med. 1990 Jun 1;171(6):2025–2041. doi: 10.1084/jem.171.6.2025. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Smith L. J., Shamsuddin M., Sporn P. H., Denenberg M., Anderson J. Reduced superoxide dismutase in lung cells of patients with asthma. Free Radic Biol Med. 1997;22(7):1301–1307. doi: 10.1016/s0891-5849(96)00550-3. [DOI] [PubMed] [Google Scholar]
  45. Soutar A., Seaton A., Brown K. Bronchial reactivity and dietary antioxidants. Thorax. 1997 Feb;52(2):166–170. doi: 10.1136/thx.52.2.166. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Tenscher K., Metzner B., Schöpf E., Norgauer J., Czech W. Recombinant human eotaxin induces oxygen radical production, Ca(2+)-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein. Blood. 1996 Oct 15;88(8):3195–3199. [PubMed] [Google Scholar]
  47. Troisi R. J., Willett W. C., Weiss S. T., Trichopoulos D., Rosner B., Speizer F. E. A prospective study of diet and adult-onset asthma. Am J Respir Crit Care Med. 1995 May;151(5):1401–1408. doi: 10.1164/ajrccm.151.5.7735592. [DOI] [PubMed] [Google Scholar]
  48. Uchida K., Shiraishi M., Naito Y., Torii Y., Nakamura Y., Osawa T. Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J Biol Chem. 1999 Jan 22;274(4):2234–2242. doi: 10.1074/jbc.274.4.2234. [DOI] [PubMed] [Google Scholar]
  49. Vachier I., Damon M., Le Doucen C., de Paulet A. C., Chanez P., Michel F. B., Godard P. Increased oxygen species generation in blood monocytes of asthmatic patients. Am Rev Respir Dis. 1992 Nov;146(5 Pt 1):1161–1166. doi: 10.1164/ajrccm/146.5_Pt_1.1161. [DOI] [PubMed] [Google Scholar]
  50. Wu W., Chen Y., Hazen S. L. Eosinophil peroxidase nitrates protein tyrosyl residues. Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders. J Biol Chem. 1999 Sep 3;274(36):25933–25944. doi: 10.1074/jbc.274.36.25933. [DOI] [PubMed] [Google Scholar]

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