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. 2001 Dec;10(Suppl 1):i4–i11. doi: 10.1136/tc.10.suppl_1.i4

Health impact of "reduced yield" cigarettes: a critical assessment of the epidemiological evidence

M Thun, D Burns
PMCID: PMC1766045  PMID: 11740038

Abstract

Cigarettes with lower machine measured "tar" and nicotine yields have been marketed as "safer" than high tar products over the last four decades, but there is conflicting evidence about the impact of these products on the disease burden caused by smoking. This paper critically examines the epidemiological evidence relevant to the health consequences of "reduced yield" cigarettes. Some epidemiological studies have found attenuated risk of lung cancer but not other diseases, among people who smoke "reduced yield" cigarettes compared to smokers of unfiltered, high yield products. These studies probably overestimate the magnitude of any association with lung cancer by over adjusting for the number of cigarettes smoked per day (one aspect of compensatory smoking), and by not fully considering other differences between smokers of "high yield" and "low yield" cigarettes. Selected cohort studies in the USA and UK show that lung cancer risk continued to increase among older smokers from the 1950s to the 1980s, despite the widespread adoption of lower yield cigarettes. The change to filter tip products did not prevent a progressive increase in lung cancer risk among male smokers who began smoking during and after the second world war compared to the first world war era smokers. National trends in vital statistics data show declining lung cancer death rates in young adults, especially males, in many countries, but the extent to which this is attributable to "reduced yield" cigarettes remains unclear. No studies have adequately assessed whether health claims used to market "reduced yield" cigarettes delay cessation among smokers who might otherwise quit, or increase initiation among non-smokers. There is no convincing evidence that past changes in cigarette design have resulted in an important health benefit to either smokers or the whole population. Tobacco control policies should not allow changes in cigarette design to subvert or distract from interventions proven to reduce the prevalence, intensity, and duration of smoking.


Keywords: tar and nicotine; lung cancer; changing cigarette

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Selected References

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  1. Agudo A., Barnadas A., Pallares C., Martinez I., Fabregat X., Rosello J., Estape J., Planas J., Gonzalez C. A. Lung cancer and cigarette smoking in women: a case-control study in Barcelona (Spain). Int J Cancer. 1994 Oct 15;59(2):165–169. doi: 10.1002/ijc.2910590204. [DOI] [PubMed] [Google Scholar]
  2. Alderson M. R., Lee P. N., Wang R. Risks of lung cancer, chronic bronchitis, ischaemic heart disease, and stroke in relation to type of cigarette smoked. J Epidemiol Community Health. 1985 Dec;39(4):286–293. doi: 10.1136/jech.39.4.286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Alderson M. R., Lee P. N., Wang R. Risks of lung cancer, chronic bronchitis, ischaemic heart disease, and stroke in relation to type of cigarette smoked. J Epidemiol Community Health. 1985 Dec;39(4):286–293. doi: 10.1136/jech.39.4.286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Armadans-Gil L., Vaqué-Rafart J., Rosselló J., Olona M., Alseda M. Cigarette smoking and male lung cancer risk with special regard to type of tobacco. Int J Epidemiol. 1999 Aug;28(4):614–619. doi: 10.1093/ije/28.4.614. [DOI] [PubMed] [Google Scholar]
  5. Augustine A., Harris R. E., Wynder E. L. Compensation as a risk factor for lung cancer in smokers who switch from nonfilter to filter cigarettes. Am J Public Health. 1989 Feb;79(2):188–191. doi: 10.2105/ajph.79.2.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Benhamou E., Benhamou S., Auquier A., Flamant R. Changes in patterns of cigarette smoking and lung cancer risk: results of a case-control study. Br J Cancer. 1989 Oct;60(4):601–604. doi: 10.1038/bjc.1989.322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Benhamou E., Benhamou S. Black (air-cured) and blond (flue-cured) tobacco and cancer risk. VI: Lung cancer. Eur J Cancer. 1993;29A(12):1778–1780. doi: 10.1016/0959-8049(93)90124-x. [DOI] [PubMed] [Google Scholar]
  8. Benhamou E., Benhamou S., Flamant R. Lung cancer and women: results of a French case-control study. Br J Cancer. 1987 Jan;55(1):91–95. doi: 10.1038/bjc.1987.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Benhamou S., Benhamou E., Auquier A., Flamant R. Differential effects of tar content, type of tobacco and use of a filter on lung cancer risk in male cigarette smokers. Int J Epidemiol. 1994 Jun;23(3):437–443. doi: 10.1093/ije/23.3.437. [DOI] [PubMed] [Google Scholar]
  10. Benhamou S., Benhamou E., Tirmarche M., Flamant R. Lung cancer and use of cigarettes: a French case-control study. J Natl Cancer Inst. 1985 Jun;74(6):1169–1175. [PubMed] [Google Scholar]
  11. Benowitz N. L., Henningfield J. E. Establishing a nicotine threshold for addiction. The implications for tobacco regulation. N Engl J Med. 1994 Jul 14;331(2):123–125. doi: 10.1056/NEJM199407143310212. [DOI] [PubMed] [Google Scholar]
  12. Benowitz N. L., Jacob P., 3rd Nicotine and carbon monoxide intake from high- and low-yield cigarettes. Clin Pharmacol Ther. 1984 Aug;36(2):265–270. doi: 10.1038/clpt.1984.173. [DOI] [PubMed] [Google Scholar]
  13. Benowitz N. L., Jacob P., 3rd Nicotine renal excretion rate influences nicotine intake during cigarette smoking. J Pharmacol Exp Ther. 1985 Jul;234(1):153–155. [PubMed] [Google Scholar]
  14. Blizzard L., Dwyer T. Declining lung cancer mortality of young Australian women despite increased smoking is linked to reduced cigarette 'tar' yields. Br J Cancer. 2001 Feb 2;84(3):392–396. doi: 10.1054/bjoc.2000.1558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Borland C., Chamberlain A., Higenbottam T., Shipley M., Rose G. Carbon monoxide yield of cigarettes and its relation to cardiorespiratory disease. Br Med J (Clin Res Ed) 1983 Nov 26;287(6405):1583–1586. doi: 10.1136/bmj.287.6405.1583. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Bross I. D., Gibson R. Risks of lung cancer in smokers who switch to filter cigarettes. Am J Public Health Nations Health. 1968 Aug;58(8):1396–1403. doi: 10.2105/ajph.58.8.1396. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Brown C. A., Crombie I. K., Smith W. C., Tunstall-Pedoe H. Cigarette tar content and symptoms of chronic bronchitis: results of the Scottish Heart Health Study. J Epidemiol Community Health. 1991 Dec;45(4):287–290. doi: 10.1136/jech.45.4.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Cade J. E., Margetts B. M. Relationship between diet and smoking--is the diet of smokers different? J Epidemiol Community Health. 1991 Dec;45(4):270–272. doi: 10.1136/jech.45.4.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. DOLL R., HILL A. B. A study of the aetiology of carcinoma of the lung. Br Med J. 1952 Dec 13;2(4797):1271–1286. doi: 10.1136/bmj.2.4797.1271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. DOLL R., HILL A. B. The mortality of doctors in relation to their smoking habits; a preliminary report. Br Med J. 1954 Jun 26;1(4877):1451–1455. doi: 10.1136/bmj.1.4877.1451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. De Stefani E., Fierro L., Correa P., Fontham E., Ronco A., Larrinaga M., Balbi J., Mendilaharsu M. Mate drinking and risk of lung cancer in males: a case-control study from Uruguay. Cancer Epidemiol Biomarkers Prev. 1996 Jul;5(7):515–519. [PubMed] [Google Scholar]
  22. Dean G., Lee P. N., Todd G. F., Wicken A. J., Sparks D. N. Factors related to respiratory and cardiovascular symptoms in the United Kingdom. J Epidemiol Community Health. 1978 Jun;32(2):86–96. doi: 10.1136/jech.32.2.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Doll R., Peto R. Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers. J Epidemiol Community Health. 1978 Dec;32(4):303–313. doi: 10.1136/jech.32.4.303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Doll R., Peto R., Wheatley K., Gray R., Sutherland I. Mortality in relation to smoking: 40 years' observations on male British doctors. BMJ. 1994 Oct 8;309(6959):901–911. doi: 10.1136/bmj.309.6959.901. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Engeland A., Haldorsen T., Andersen A., Tretli S. The impact of smoking habits on lung cancer risk: 28 years' observation of 26,000 Norwegian men and women. Cancer Causes Control. 1996 May;7(3):366–376. doi: 10.1007/BF00052943. [DOI] [PubMed] [Google Scholar]
  26. Frost C., Fullerton F. M., Stephen A. M., Stone R., Nicolaides-Bouman A., Densem J., Wald N. J., Semmence A. The tar reduction study: randomised trial of the effect of cigarette tar yield reduction on compensatory smoking. Thorax. 1995 Oct;50(10):1038–1043. doi: 10.1136/thx.50.10.1038. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Gillis C. R., Hole D. J., Boyle P. Cigarette smoking and male lung cancer in an area of very high incidence. I. Report of a case-control study in the West of Scotland. J Epidemiol Community Health. 1988 Mar;42(1):38–43. doi: 10.1136/jech.42.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Gori G. B., Lynch C. J. Smoker intake from cigarettes in the 1-mg Federal Trade Commission tar class. Regul Toxicol Pharmacol. 1983 Jun;3(2):110–120. doi: 10.1016/0273-2300(83)90035-1. [DOI] [PubMed] [Google Scholar]
  29. Guyatt A. R., Kirkham A. J., Mariner D. C., Baldry A. G., Cumming G. Long-term effects of switching to cigarettes with lower tar and nicotine yields. Psychopharmacology (Berl) 1989;99(1):80–86. doi: 10.1007/BF00634457. [DOI] [PubMed] [Google Scholar]
  30. Hammond E. C., Garfinkel L., Seidman H., Lew E. A. "Tar" and nicotine content of cigarette smoke in relation to death rates. Environ Res. 1976 Dec;12(3):263–274. doi: 10.1016/0013-9351(76)90036-0. [DOI] [PubMed] [Google Scholar]
  31. Hawthorne V. M., Fry J. S. Smoking and health: the association between smoking behaviour, total mortality, and cardiorespiratory disease in west central Scotland. J Epidemiol Community Health. 1978 Dec;32(4):260–266. doi: 10.1136/jech.32.4.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Higenbottam T., Shipley M. J., Rose G. Cigarettes, lung cancer, and coronary heart disease: the effects of inhalation and tar yield. J Epidemiol Community Health. 1982 Jun;36(2):113–117. doi: 10.1136/jech.36.2.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Jarvis M. J., Boreham R., Primatesta P., Feyerabend C., Bryant A. Nicotine yield from machine-smoked cigarettes and nicotine intakes in smokers: evidence from a representative population survey. J Natl Cancer Inst. 2001 Jan 17;93(2):134–138. doi: 10.1093/jnci/93.2.134. [DOI] [PubMed] [Google Scholar]
  34. Jemal A., Chu K. C., Tarone R. E. Recent trends in lung cancer mortality in the United States. J Natl Cancer Inst. 2001 Feb 21;93(4):277–283. doi: 10.1093/jnci/93.4.277. [DOI] [PubMed] [Google Scholar]
  35. Jöckel K. H., Ahrens W., Wichmann H. E., Becher H., Bolm-Audorff U., Jahn I., Molik B., Greiser E., Timm J. Occupational and environmental hazards associated with lung cancer. Int J Epidemiol. 1992 Apr;21(2):202–213. doi: 10.1093/ije/21.2.202. [DOI] [PubMed] [Google Scholar]
  36. Kabat G. C. Aspects of the epidemiology of lung cancer in smokers and nonsmokers in the United States. Lung Cancer. 1996 Aug;15(1):1–20. doi: 10.1016/0169-5002(95)00566-8. [DOI] [PubMed] [Google Scholar]
  37. Kaufman D. W., Palmer J. R., Rosenberg L., Stolley P., Warshauer E., Shapiro S. Tar content of cigarettes in relation to lung cancer. Am J Epidemiol. 1989 Apr;129(4):703–711. doi: 10.1093/oxfordjournals.aje.a115185. [DOI] [PubMed] [Google Scholar]
  38. Khuder S. A., Dayal H. H., Mutgi A. B., Willey J. C., Dayal G. Effect of cigarette smoking on major histological types of lung cancer in men. Lung Cancer. 1998 Oct;22(1):15–21. doi: 10.1016/s0169-5002(98)00068-3. [DOI] [PubMed] [Google Scholar]
  39. Kozlowski L. T., Mehta N. Y., Sweeney C. T., Schwartz S. S., Vogler G. P., Jarvis M. J., West R. J. Filter ventilation and nicotine content of tobacco in cigarettes from Canada, the United Kingdom, and the United States. Tob Control. 1998 Winter;7(4):369–375. doi: 10.1136/tc.7.4.369. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Krzyzanowski M., Sherrill D. L., Paoletti P., Lebowitz M. D. Relationship of respiratory symptoms and pulmonary function to tar, nicotine, and carbon monoxide yield of cigarettes. Am Rev Respir Dis. 1991 Feb;143(2):306–311. doi: 10.1164/ajrccm/143.2.306. [DOI] [PubMed] [Google Scholar]
  41. Kuller L. H., Ockene J. K., Meilahn E., Wentworth D. N., Svendsen K. H., Neaton J. D. Cigarette smoking and mortality. MRFIT Research Group. Prev Med. 1991 Sep;20(5):638–654. doi: 10.1016/0091-7435(91)90060-h. [DOI] [PubMed] [Google Scholar]
  42. Lange P., Nyboe J., Appleyard M., Jensen G., Schnohr P. Relationship of the type of tobacco and inhalation pattern to pulmonary and total mortality. Eur Respir J. 1992 Oct;5(9):1111–1117. [PubMed] [Google Scholar]
  43. Lange P., Nyboe J., Appleyard M., Jensen G., Schnohr P. Relationship of the type of tobacco and inhalation pattern to pulmonary and total mortality. Eur Respir J. 1992 Oct;5(9):1111–1117. [PubMed] [Google Scholar]
  44. Lee P. N., Garfinkel L. Mortality and type of cigarette smoked. J Epidemiol Community Health. 1981 Mar;35(1):16–22. doi: 10.1136/jech.35.1.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Lubin J. H., Blot W. J., Berrino F., Flamant R., Gillis C. R., Kunze M., Schmahl D., Visco G. Patterns of lung cancer risk according to type of cigarette smoked. Int J Cancer. 1984 May 15;33(5):569–576. doi: 10.1002/ijc.2910330504. [DOI] [PubMed] [Google Scholar]
  46. Lubin J. H., Blot W. J., Berrino F., Flamant R., Gillis C. R., Kunze M., Schmähl D., Visco G. Modifying risk of developing lung cancer by changing habits of cigarette smoking. Br Med J (Clin Res Ed) 1984 Jun 30;288(6435):1953–1956. doi: 10.1136/bmj.288.6435.1953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Lynch C. J., Benowitz N. L. Spontaneous cigarette brand switching: consequences for nicotine and carbon monoxide exposure. Am J Public Health. 1987 Sep;77(9):1191–1194. doi: 10.2105/ajph.77.9.1191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Mannino D. M., Ford E., Giovino G. A., Thun M. Lung cancer mortality rates in birth cohorts in the United States from 1960 to 1994. Lung Cancer. 2001 Feb-Mar;31(2-3):91–99. doi: 10.1016/s0169-5002(00)00170-7. [DOI] [PubMed] [Google Scholar]
  49. Matos E., Vilensky M., Boffetta P., Kogevinas M. Lung cancer and smoking: a case-control study in Buenos Aires, Argentina. Lung Cancer. 1998 Sep;21(3):155–163. doi: 10.1016/s0169-5002(98)00055-5. [DOI] [PubMed] [Google Scholar]
  50. Midgette A. S., Baron J. A., Rohan T. E. Do cigarette smokers have diets that increase their risks of coronary heart disease and cancer? Am J Epidemiol. 1993 Mar 1;137(5):521–529. doi: 10.1093/oxfordjournals.aje.a116705. [DOI] [PubMed] [Google Scholar]
  51. Negri E., Franzosi M. G., La Vecchia C., Santoro L., Nobili A., Tognoni G. Tar yield of cigarettes and risk of acute myocardial infarction. GISSI-EFRIM Investigators. BMJ. 1993 Jun 12;306(6892):1567–1570. doi: 10.1136/bmj.306.6892.1567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Palmer J. R., Rosenberg L., Shapiro S. "Low yield" cigarettes and the risk of nonfatal myocardial infarction in women. N Engl J Med. 1989 Jun 15;320(24):1569–1573. doi: 10.1056/NEJM198906153202401. [DOI] [PubMed] [Google Scholar]
  53. Parish S., Collins R., Peto R., Youngman L., Barton J., Jayne K., Clarke R., Appleby P., Lyon V., Cederholm-Williams S. Cigarette smoking, tar yields, and non-fatal myocardial infarction: 14,000 cases and 32,000 controls in the United Kingdom. The International Studies of Infarct Survival (ISIS) Collaborators. BMJ. 1995 Aug 19;311(7003):471–477. doi: 10.1136/bmj.311.7003.471. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Pathak D. R., Samet J. M., Humble C. G., Skipper B. J. Determinants of lung cancer risk in cigarette smokers in New Mexico. J Natl Cancer Inst. 1986 Apr;76(4):597–604. doi: 10.1093/jnci/76.4.597. [DOI] [PubMed] [Google Scholar]
  55. Peach H., Hayward D. M., Ellard D. R., Morris R. W., Shah D. Phlegm production and lung function among cigarette smokers changing tar groups during the 1970s. J Epidemiol Community Health. 1986 Jun;40(2):110–116. doi: 10.1136/jech.40.2.110. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Peach H., Hayward D. M., Shah D., Ellard G. A. A double-blind randomized controlled trial of the effect of a low- versus a middle-tar cigarette on respiratory symptoms--a feasibility study. IARC Sci Publ. 1986;(74):251–263. [PubMed] [Google Scholar]
  57. Petitti D. B., Friedman G. D. Cardiovascular and other diseases in smokers of low yield cigarettes. J Chronic Dis. 1985;38(7):581–588. doi: 10.1016/0021-9681(85)90047-5. [DOI] [PubMed] [Google Scholar]
  58. Peto R., Darby S., Deo H., Silcocks P., Whitley E., Doll R. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ. 2000 Aug 5;321(7257):323–329. doi: 10.1136/bmj.321.7257.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Pezzotto S. M., Mahuad R., Bay M. L., Morini J. C., Poletto L. Variation in smoking-related lung cancer risk factors by cell type among men in Argentina: a case-control study. Cancer Causes Control. 1993 May;4(3):231–237. doi: 10.1007/BF00051318. [DOI] [PubMed] [Google Scholar]
  60. Powell J. T., Edwards R. J., Worrell P. C., Franks P. J., Greenhalgh R. M., Poulter N. R. Risk factors associated with the development of peripheral arterial disease in smokers: a case-control study. Atherosclerosis. 1997 Feb 28;129(1):41–48. doi: 10.1016/s0021-9150(96)06012-1. [DOI] [PubMed] [Google Scholar]
  61. Rimington J. The effect of filters on the incidence of lung cancer in cigarette smokers. Environ Res. 1981 Feb;24(1):162–166. doi: 10.1016/0013-9351(81)90142-0. [DOI] [PubMed] [Google Scholar]
  62. Robinson J. C., Young J. C., Rickert W. S., Fey G., Kozlowski L. T. A comparative study of the amount of smoke absorbed from low yield ('less hazardous') cigarettes. Part 2: Invasive measures. Br J Addict. 1983 Mar;78(1):79–87. doi: 10.1111/j.1360-0443.1983.tb02483.x. [DOI] [PubMed] [Google Scholar]
  63. Russell M. A., Sutton S. R., Iyer R., Feyerabend C., Vesey C. J. Long-term switching to low-tar low-nicotine cigarettes. Br J Addict. 1982 Jun;77(2):145–158. doi: 10.1111/j.1360-0443.1982.tb01416.x. [DOI] [PubMed] [Google Scholar]
  64. Russell M. A., Wilson C., Patel U. A., Feyerabend C., Cole P. V. Plasma nicotine levels after smoking cigarettes with high, medium, and low nicotine yields. Br Med J. 1975 May 24;2(5968):414–416. doi: 10.1136/bmj.2.5968.414. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Shiffman S. Tobacco "chippers"--individual differences in tobacco dependence. Psychopharmacology (Berl) 1989;97(4):539–547. doi: 10.1007/BF00439561. [DOI] [PubMed] [Google Scholar]
  66. Sidney S., Tekawa I. S., Friedman G. D. A prospective study of cigarette tar yield and lung cancer. Cancer Causes Control. 1993 Jan;4(1):3–10. doi: 10.1007/BF00051707. [DOI] [PubMed] [Google Scholar]
  67. Sparrow D., Stefos T., Bossé R., Weiss S. T. The relationship of tar content to decline in pulmonary function in cigarette smokers. Am Rev Respir Dis. 1983 Jan;127(1):56–58. doi: 10.1164/arrd.1983.127.1.56. [DOI] [PubMed] [Google Scholar]
  68. Stellman S. D., Muscat J. E., Thompson S., Hoffmann D., Wynder E. L. Risk of squamous cell carcinoma and adenocarcinoma of the lung in relation to lifetime filter cigarette smoking. Cancer. 1997 Aug 1;80(3):382–388. doi: 10.1002/(sici)1097-0142(19970801)80:3<382::aid-cncr5>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  69. Subar A. F., Harlan L. C., Mattson M. E. Food and nutrient intake differences between smokers and non-smokers in the US. Am J Public Health. 1990 Nov;80(11):1323–1329. doi: 10.2105/ajph.80.11.1323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Tang J. L., Morris J. K., Wald N. J., Hole D., Shipley M., Tunstall-Pedoe H. Mortality in relation to tar yield of cigarettes: a prospective study of four cohorts. BMJ. 1995 Dec 9;311(7019):1530–1533. doi: 10.1136/bmj.311.7019.1530. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Thun M. J., Heath C. W., Jr Changes in mortality from smoking in two American Cancer Society prospective studies since 1959. Prev Med. 1997 Jul-Aug;26(4):422–426. doi: 10.1006/pmed.1997.0182. [DOI] [PubMed] [Google Scholar]
  72. Thun M. J., Heath C. W., Jr Changes in mortality from smoking in two American Cancer Society prospective studies since 1959. Prev Med. 1997 Jul-Aug;26(4):422–426. doi: 10.1006/pmed.1997.0182. [DOI] [PubMed] [Google Scholar]
  73. Todd G. F., Hunt B. M., Lambert P. M. Four cardiorespiratory symptoms as predictors of mortality. J Epidemiol Community Health. 1978 Dec;32(4):267–274. doi: 10.1136/jech.32.4.267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Vutuc C., Kunze M. Lung cancer risk in women in relation to tar yields of cigarettes. Prev Med. 1982 Nov;11(6):713–716. doi: 10.1016/0091-7435(82)90033-0. [DOI] [PubMed] [Google Scholar]
  75. Vutuc C., Kunze M. Tar yields of cigarettes and male lung cancer risk. J Natl Cancer Inst. 1983 Sep;71(3):435–437. [PubMed] [Google Scholar]
  76. WYNDER E. L., GRAHAM E. A., CRONINGER A. B. Experimental production of carcinoma with cigarette tar. Cancer Res. 1953 Dec;13(12):855–864. [PubMed] [Google Scholar]
  77. WYNDER E. L., GRAHAM E. A. Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma; a study of 684 proved cases. J Am Med Assoc. 1950 May 27;143(4):329–336. doi: 10.1001/jama.1950.02910390001001. [DOI] [PubMed] [Google Scholar]
  78. West R. J., Russell M. A., Jarvis M. J., Feyerabend C. Does switching to an ultra-low nicotine cigarette induce nicotine withdrawal effects? Psychopharmacology (Berl) 1984;84(1):120–123. doi: 10.1007/BF00432039. [DOI] [PubMed] [Google Scholar]
  79. Wilcox H. B., Schoenberg J. B., Mason T. J., Bill J. S., Stemhagen A. Smoking and lung cancer: risk as a function of cigarette tar content. Prev Med. 1988 May;17(3):263–272. doi: 10.1016/0091-7435(88)90002-3. [DOI] [PubMed] [Google Scholar]
  80. Withey C. H., Papacosta A. O., Swan A. V., Fitzsimons B. A., Ellard G. A., Burney P. G., Colley J. R., Holland W. W. Respiratory effects of lowering tar and nicotine levels of cigarettes smoked by young male middle tar smokers. II. Results of a randomised controlled trial. J Epidemiol Community Health. 1992 Jun;46(3):281–285. doi: 10.1136/jech.46.3.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Wynder E. L., Kabat G. C. The effect of low-yield cigarette smoking on lung cancer risk. Cancer. 1988 Sep 15;62(6):1223–1230. doi: 10.1002/1097-0142(19880915)62:6<1223::aid-cncr2820620630>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  82. Wynder E. L., Mabuchi K., Beattie E. J., Jr The epidemiology of lung cancer. Recent trends. JAMA. 1970 Sep 28;213(13):2221–2228. [PubMed] [Google Scholar]
  83. Wynder E. L., Stellman S. D. Impact of long-term filter cigarette usage on lung and larynx cancer risk: a case-control study. J Natl Cancer Inst. 1979 Mar;62(3):471–477. doi: 10.1093/jnci/62.3.471. [DOI] [PubMed] [Google Scholar]
  84. Zacny J. P., Stitzer M. L. Cigarette brand-switching: effects on smoke exposure and smoking behavior. J Pharmacol Exp Ther. 1988 Aug;246(2):619–627. [PubMed] [Google Scholar]
  85. Zondervan K. T., Ocké M. C., Smit H. A., Seidell J. C. Do dietary and supplementary intakes of antioxidants differ with smoking status? Int J Epidemiol. 1996 Feb;25(1):70–79. doi: 10.1093/ije/25.1.70. [DOI] [PubMed] [Google Scholar]

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