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. 1999 Sep;82(Suppl 1):I2–I4. doi: 10.1136/hrt.82.2008.i2

Pathogenic mechanisms in unstable angina

A Maseri, G Liuzzo, L Biasucci
PMCID: PMC1766499  PMID: 10469669

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Figure 1  .

Figure 1  

Mortality of patients with unstable angina over time.

Figure 2  .

Figure 2  

Event free survival over 12 months according to CRP concentrations at hospital discharge.

Figure 3  .

Figure 3  

Mechanisms for the development of myocardial ischaemia in unstable angina. Reproduced from Maseri14 with permission of Churchill Livingstone.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Biasucci L. M., Liuzzo G., Fantuzzi G., Caligiuri G., Rebuzzi A. G., Ginnetti F., Dinarello C. A., Maseri A. Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events. Circulation. 1999 Apr 27;99(16):2079–2084. doi: 10.1161/01.cir.99.16.2079. [DOI] [PubMed] [Google Scholar]
  2. Biasucci L. M., Vitelli A., Liuzzo G., Altamura S., Caligiuri G., Monaco C., Rebuzzi A. G., Ciliberto G., Maseri A. Elevated levels of interleukin-6 in unstable angina. Circulation. 1996 Sep 1;94(5):874–877. doi: 10.1161/01.cir.94.5.874. [DOI] [PubMed] [Google Scholar]
  3. Caligiuri G., Liuzzo G., Biasucci L. M., Maseri A. Immune system activation follows inflammation in unstable angina: pathogenetic implications. J Am Coll Cardiol. 1998 Nov;32(5):1295–1304. doi: 10.1016/s0735-1097(98)00410-0. [DOI] [PubMed] [Google Scholar]
  4. Cianflone D., Ciccirillo F., Buffon A., Trani C., Scabbia E. V., Finocchiaro M. L., Crea F. Comparison of coronary angiographic narrowing in stable angina pectoris, unstable angina pectoris, and in acute myocardial infarction. Am J Cardiol. 1995 Aug 1;76(4):215–219. doi: 10.1016/s0002-9149(99)80068-x. [DOI] [PubMed] [Google Scholar]
  5. Davies M. J., Thomas A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. N Engl J Med. 1984 May 3;310(18):1137–1140. doi: 10.1056/NEJM198405033101801. [DOI] [PubMed] [Google Scholar]
  6. Farb A., Burke A. P., Tang A. L., Liang T. Y., Mannan P., Smialek J., Virmani R. Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. Circulation. 1996 Apr 1;93(7):1354–1363. doi: 10.1161/01.cir.93.7.1354. [DOI] [PubMed] [Google Scholar]
  7. Ferguson J. J. American College of Cardiology 45th Annual Scientific Session, Orlando, Florida, March 24 to 27, 1996. Circulation. 1996 Jul 1;94(1):1–5. doi: 10.1161/01.cir.94.1.1. [DOI] [PubMed] [Google Scholar]
  8. Gupta S., Leatham E. W., Carrington D., Mendall M. A., Kaski J. C., Camm A. J. Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. Circulation. 1997 Jul 15;96(2):404–407. doi: 10.1161/01.cir.96.2.404. [DOI] [PubMed] [Google Scholar]
  9. Gurfinkel E., Bozovich G., Daroca A., Beck E., Mautner B. Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS Pilot Study. ROXIS Study Group. Lancet. 1997 Aug 9;350(9075):404–407. doi: 10.1016/s0140-6736(97)07201-2. [DOI] [PubMed] [Google Scholar]
  10. Liuzzo G., Biasucci L. M., Gallimore J. R., Grillo R. L., Rebuzzi A. G., Pepys M. B., Maseri A. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med. 1994 Aug 18;331(7):417–424. doi: 10.1056/NEJM199408183310701. [DOI] [PubMed] [Google Scholar]
  11. Liuzzo G., Buffon A., Biasucci L. M., Gallimore J. R., Caligiuri G., Vitelli A., Altamura S., Ciliberto G., Rebuzzi A. G., Crea F. Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina. Circulation. 1998 Dec 1;98(22):2370–2376. doi: 10.1161/01.cir.98.22.2370. [DOI] [PubMed] [Google Scholar]
  12. Rebuzzi A. G., Quaranta G., Liuzzo G., Caligiuri G., Lanza G. A., Gallimore J. R., Grillo R. L., Cianflone D., Biasucci L. M., Maseri A. Incremental prognostic value of serum levels of troponin T and C-reactive protein on admission in patients with unstable angina pectoris. Am J Cardiol. 1998 Sep 15;82(6):715–719. doi: 10.1016/s0002-9149(98)00458-5. [DOI] [PubMed] [Google Scholar]
  13. van der Wal A. C., Becker A. E., Koch K. T., Piek J. J., Teeling P., van der Loos C. M., David G. K. Clinically stable angina pectoris is not necessarily associated with histologically stable atherosclerotic plaques. Heart. 1996 Oct;76(4):312–316. doi: 10.1136/hrt.76.4.312. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. van der Wal A. C., Becker A. E., van der Loos C. M., Das P. K. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 1994 Jan;89(1):36–44. doi: 10.1161/01.cir.89.1.36. [DOI] [PubMed] [Google Scholar]

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