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. 1999 Nov;82(Suppl 3):III1–III7. doi: 10.1136/hrt.82.2008.iii1

Pathophysiology of myocardial hibernation. Implications for the use of dobutamine echocardiography to identify myocardial viability

J Vanoverschelde, A Pasquet, B Gerber, J Melin
PMCID: PMC1766513  PMID: 10534324

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Selected References

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  1. Afridi I., Grayburn P. A., Panza J. A., Oh J. K., Zoghbi W. A., Marwick T. H. Myocardial viability during dobutamine echocardiography predicts survival in patients with coronary artery disease and severe left ventricular systolic dysfunction. J Am Coll Cardiol. 1998 Oct;32(4):921–926. doi: 10.1016/s0735-1097(98)00321-0. [DOI] [PubMed] [Google Scholar]
  2. Afridi I., Kleiman N. S., Raizner A. E., Zoghbi W. A. Dobutamine echocardiography in myocardial hibernation. Optimal dose and accuracy in predicting recovery of ventricular function after coronary angioplasty. Circulation. 1995 Feb 1;91(3):663–670. doi: 10.1161/01.cir.91.3.663. [DOI] [PubMed] [Google Scholar]
  3. Alfieri O., La Canna G., Giubbini R., Pardini A., Zogno M., Fucci C. Recovery of myocardial function. The ultimate target of coronary revascularization. Eur J Cardiothorac Surg. 1993;7(6):325–330. doi: 10.1016/1010-7940(93)90175-b. [DOI] [PubMed] [Google Scholar]
  4. Arai A. E., Pantely G. A., Anselone C. G., Bristow J., Bristow J. D. Active downregulation of myocardial energy requirements during prolonged moderate ischemia in swine. Circ Res. 1991 Dec;69(6):1458–1469. doi: 10.1161/01.res.69.6.1458. [DOI] [PubMed] [Google Scholar]
  5. Arnese M., Cornel J. H., Salustri A., Maat A., Elhendy A., Reijs A. E., Ten Cate F. J., Keane D., Balk A. H., Roelandt J. R. Prediction of improvement of regional left ventricular function after surgical revascularization. A comparison of low-dose dobutamine echocardiography with 201Tl single-photon emission computed tomography. Circulation. 1995 Jun 1;91(11):2748–2752. doi: 10.1161/01.cir.91.11.2748. [DOI] [PubMed] [Google Scholar]
  6. Baer F. M., Voth E., Deutsch H. J., Schneider C. A., Schicha H., Sechtem U. Assessment of viable myocardium by dobutamine transesophageal echocardiography and comparison with fluorine-18 fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol. 1994 Aug;24(2):343–353. doi: 10.1016/0735-1097(94)90286-0. [DOI] [PubMed] [Google Scholar]
  7. Barzilai B., Madaras E. I., Sobel B. E., Miller J. G., Pérez J. E. Effects of myocardial contraction on ultrasonic backscatter before and after ischemia. Am J Physiol. 1984 Sep;247(3 Pt 2):H478–H483. doi: 10.1152/ajpheart.1984.247.3.H478. [DOI] [PubMed] [Google Scholar]
  8. Bax J. J., Cornel J. H., Visser F. C., Fioretti P. M., van Lingen A., Reijs A. E., Boersma E., Teule G. J., Visser C. A. Prediction of recovery of myocardial dysfunction after revascularization. Comparison of fluorine-18 fluorodeoxyglucose/thallium-201 SPECT, thallium-201 stress-reinjection SPECT and dobutamine echocardiography. J Am Coll Cardiol. 1996 Sep;28(3):558–564. doi: 10.1016/0735-1097(96)00222-7. [DOI] [PubMed] [Google Scholar]
  9. Becker L. C., Levine J. H., DiPaula A. F., Guarnieri T., Aversano T. Reversal of dysfunction in postischemic stunned myocardium by epinephrine and postextrasystolic potentiation. J Am Coll Cardiol. 1986 Mar;7(3):580–589. doi: 10.1016/s0735-1097(86)80468-5. [DOI] [PubMed] [Google Scholar]
  10. Bolukoglu H., Liedtke A. J., Nellis S. H., Eggleston A. M., Subramanian R., Renstrom B. An animal model of chronic coronary stenosis resulting in hibernating myocardium. Am J Physiol. 1992 Jul;263(1 Pt 2):H20–H29. doi: 10.1152/ajpheart.1992.263.1.H20. [DOI] [PubMed] [Google Scholar]
  11. Braunwald E., Rutherford J. D. Reversible ischemic left ventricular dysfunction: evidence for the "hibernating myocardium". J Am Coll Cardiol. 1986 Dec;8(6):1467–1470. doi: 10.1016/s0735-1097(86)80325-4. [DOI] [PubMed] [Google Scholar]
  12. Canty J. M., Jr, Klocke F. J. Reductions in regional myocardial function at rest in conscious dogs with chronically reduced regional coronary artery pressure. Circ Res. 1987 Nov;61(5 Pt 2):II107–II116. [PubMed] [Google Scholar]
  13. Charney R., Schwinger M. E., Chun J., Cohen M. V., Nanna M., Menegus M. A., Wexler J., Franco H. S., Greenberg M. A. Dobutamine echocardiography and resting-redistribution thallium-201 scintigraphy predicts recovery of hibernating myocardium after coronary revascularization. Am Heart J. 1994 Nov;128(5):864–869. doi: 10.1016/0002-8703(94)90581-9. [DOI] [PubMed] [Google Scholar]
  14. Chen C., Chen L., Fallon J. T., Ma L., Li L., Bow L., Knibbs D., McKay R., Gillam L. D., Waters D. D. Functional and structural alterations with 24-hour myocardial hibernation and recovery after reperfusion. A pig model of myocardial hibernation. Circulation. 1996 Aug 1;94(3):507–516. doi: 10.1161/01.cir.94.3.507. [DOI] [PubMed] [Google Scholar]
  15. Chen C., Li L., Chen L. L., Prada J. V., Chen M. H., Fallon J. T., Weyman A. E., Waters D., Gillam L. Incremental doses of dobutamine induce a biphasic response in dysfunctional left ventricular regions subtending coronary stenoses. Circulation. 1995 Aug 15;92(4):756–766. doi: 10.1161/01.cir.92.4.756. [DOI] [PubMed] [Google Scholar]
  16. Chen C., Ma L., Linfert D. R., Lai T., Fallon J. T., Gillam L. D., Waters D. D., Tsongalis G. J. Myocardial cell death and apoptosis in hibernating myocardium. J Am Coll Cardiol. 1997 Nov 1;30(5):1407–1412. doi: 10.1016/s0735-1097(97)00309-4. [DOI] [PubMed] [Google Scholar]
  17. Cigarroa C. G., deFilippi C. R., Brickner M. E., Alvarez L. G., Wait M. A., Grayburn P. A. Dobutamine stress echocardiography identifies hibernating myocardium and predicts recovery of left ventricular function after coronary revascularization. Circulation. 1993 Aug;88(2):430–436. doi: 10.1161/01.cir.88.2.430. [DOI] [PubMed] [Google Scholar]
  18. Conversano A., Walsh J. F., Geltman E. M., Perez J. E., Bergmann S. R., Gropler R. J. Delineation of myocardial stunning and hibernation by positron emission tomography in advanced coronary artery disease. Am Heart J. 1996 Mar;131(3):440–450. doi: 10.1016/s0002-8703(96)90521-9. [DOI] [PubMed] [Google Scholar]
  19. Cornel J. H., Bax J. J., Elhendy A., Poldermans D., Vanoverschelde J. L., Fioretti P. M. Predictive accuracy of echocardiographic response of mildly dyssynergic myocardial segments to low-dose dobutamine. Am J Cardiol. 1997 Dec 1;80(11):1481–1484. doi: 10.1016/s0002-9149(97)00721-2. [DOI] [PubMed] [Google Scholar]
  20. Depré C., Vanoverschelde J. L., Melin J. A., Borgers M., Bol A., Ausma J., Dion R., Wijns W. Structural and metabolic correlates of the reversibility of chronic left ventricular ischemic dysfunction in humans. Am J Physiol. 1995 Mar;268(3 Pt 2):H1265–H1275. doi: 10.1152/ajpheart.1995.268.3.H1265. [DOI] [PubMed] [Google Scholar]
  21. Di Carli M. F., Asgarzadie F., Schelbert H. R., Brunken R. C., Laks H., Phelps M. E., Maddahi J. Quantitative relation between myocardial viability and improvement in heart failure symptoms after revascularization in patients with ischemic cardiomyopathy. Circulation. 1995 Dec 15;92(12):3436–3444. doi: 10.1161/01.cir.92.12.3436. [DOI] [PubMed] [Google Scholar]
  22. Diamond G. A., Forrester J. S., deLuz P. L., Wyatt H. L., Swan H. J. Post-extrasystolic potentiation of ischemic myocardium by atrial stimulation. Am Heart J. 1978 Feb;95(2):204–209. doi: 10.1016/0002-8703(78)90464-7. [DOI] [PubMed] [Google Scholar]
  23. Dyke S. H., Cohn P. F., Gorlin R., Sonnenblick E. H. Detection of residual myocardial function in coronary artery disease using post-extra systolic potentiation. Circulation. 1974 Oct;50(4):694–699. doi: 10.1161/01.cir.50.4.694. [DOI] [PubMed] [Google Scholar]
  24. Ellis S. G., Wynne J., Braunwald E., Henschke C. I., Sandor T., Kloner R. A. Response of reperfusion-salvaged, stunned myocardium to inotropic stimulation. Am Heart J. 1984 Jan;107(1):13–19. doi: 10.1016/0002-8703(84)90126-1. [DOI] [PubMed] [Google Scholar]
  25. Fedele F. A., Gewirtz H., Capone R. J., Sharaf B., Most A. S. Metabolic response to prolonged reduction of myocardial blood flow distal to a severe coronary artery stenosis. Circulation. 1988 Sep;78(3):729–735. doi: 10.1161/01.cir.78.3.729. [DOI] [PubMed] [Google Scholar]
  26. Ferguson J. J. American College of Cardiology 45th Annual Scientific Session, Orlando, Florida, March 24 to 27, 1996. Circulation. 1996 Jul 1;94(1):1–5. doi: 10.1161/01.cir.94.1.1. [DOI] [PubMed] [Google Scholar]
  27. Firoozan S., Wei K., Linka A., Skyba D., Goodman N. C., Kaul S. A canine model of chronic ischemic cardiomyopathy: characterization of regional flow-function relations. Am J Physiol. 1999 Feb;276(2 Pt 2):H446–H455. doi: 10.1152/ajpheart.1999.276.2.H446. [DOI] [PubMed] [Google Scholar]
  28. Fitzgerald P. J., McDaniel M. D., Rolett E. L., Strohbehn J. W., James D. H. Two-dimensional ultrasonic tissue characterization: backscatter power, endocardial wall motion, and their phase relationship for normal, ischemic, and infarcted myocardium. Circulation. 1987 Oct;76(4):850–859. doi: 10.1161/01.cir.76.4.850. [DOI] [PubMed] [Google Scholar]
  29. Flameng W., Suy R., Schwarz F., Borgers M., Piessens J., Thone F., Van Ermen H., De Geest H. Ultrastructural correlates of left ventricular contraction abnormalities in patients with chronic ischemic heart disease: determinants of reversible segmental asynergy postrevascularization surgery. Am Heart J. 1981 Nov;102(5):846–857. doi: 10.1016/0002-8703(81)90035-1. [DOI] [PubMed] [Google Scholar]
  30. Flameng W., Vanhaecke J., Van Belle H., Borgers M., De Beer L., Minten J. Relation between coronary artery stenosis and myocardial purine metabolism, histology and regional function in humans. J Am Coll Cardiol. 1987 Jun;9(6):1235–1242. doi: 10.1016/s0735-1097(87)80461-8. [DOI] [PubMed] [Google Scholar]
  31. Flameng W., Wouters L., Sergeant P., Lewi P., Borgers M., Thone F., Suy R. Multivariate analysis of angiographic, histologic, and electrocardiographic data in patients with coronary heart disease. Circulation. 1984 Jul;70(1):7–17. doi: 10.1161/01.cir.70.1.7. [DOI] [PubMed] [Google Scholar]
  32. Gallagher K. P., Kumada T., Koziol J. A., McKown M. D., Kemper W. S., Ross J., Jr Significance of regional wall thickening abnormalities relative to transmural myocardial perfusion in anesthetized dogs. Circulation. 1980 Dec;62(6):1266–1274. doi: 10.1161/01.cir.62.6.1266. [DOI] [PubMed] [Google Scholar]
  33. Gallagher K. P., Matsuzaki M., Osakada G., Kemper W. S., Ross J., Jr Effect of exercise on the relationship between myocardial blood flow and systolic wall thickening in dogs with acute coronary stenosis. Circ Res. 1983 Jun;52(6):716–729. doi: 10.1161/01.res.52.6.716. [DOI] [PubMed] [Google Scholar]
  34. Gerber B. L., Vanoverschelde J. L., Bol A., Michel C., Labar D., Wijns W., Melin J. A. Myocardial blood flow, glucose uptake, and recruitment of inotropic reserve in chronic left ventricular ischemic dysfunction. Implications for the pathophysiology of chronic myocardial hibernation. Circulation. 1996 Aug 15;94(4):651–659. doi: 10.1161/01.cir.94.4.651. [DOI] [PubMed] [Google Scholar]
  35. Gerber B. L., Vanoverschelde J. L., Bol A., Michel C., Labar D., Wijns W., Melin J. A. Myocardial blood flow, glucose uptake, and recruitment of inotropic reserve in chronic left ventricular ischemic dysfunction. Implications for the pathophysiology of chronic myocardial hibernation. Circulation. 1996 Aug 15;94(4):651–659. doi: 10.1161/01.cir.94.4.651. [DOI] [PubMed] [Google Scholar]
  36. Glueck R. M., Mottley J. G., Miller J. G., Sobel B. E., Pérez J. E. Effects of coronary artery occlusion and reperfusion on cardiac cycle-dependent variation of myocardial ultrasonic backscatter. Circ Res. 1985 May;56(5):683–689. doi: 10.1161/01.res.56.5.683. [DOI] [PubMed] [Google Scholar]
  37. Grandin C., Wijns W., Melin J. A., Bol A., Robert A. R., Heyndrickx G. R., Michel C., Vanoverschelde J. L. Delineation of myocardial viability with PET. J Nucl Med. 1995 Sep;36(9):1543–1552. [PubMed] [Google Scholar]
  38. Gropler R. J., Geltman E. M., Sampathkumaran K., Pérez J. E., Moerlein S. M., Sobel B. E., Bergmann S. R., Siegel B. A. Functional recovery after coronary revascularization for chronic coronary artery disease is dependent on maintenance of oxidative metabolism. J Am Coll Cardiol. 1992 Sep;20(3):569–577. doi: 10.1016/0735-1097(92)90010-k. [DOI] [PubMed] [Google Scholar]
  39. Haque T., Furukawa T., Takahashi M., Kinoshita M. Identification of hibernating myocardium by dobutamine stress echocardiography: comparison with thallium-201 reinjection imaging. Am Heart J. 1995 Sep;130(3 Pt 1):553–563. doi: 10.1016/0002-8703(95)90366-6. [DOI] [PubMed] [Google Scholar]
  40. Hata T., Nohara R., Fujita M., Hosokawa R., Lee L., Kudo T., Tadamura E., Tamaki N., Konishi J., Sasayama S. Noninvasive assessment of myocardial viability by positron emission tomography with 11C acetate in patients with old myocardial infarction. Usefulness of low-dose dobutamine infusion. Circulation. 1996 Oct 15;94(8):1834–1841. doi: 10.1161/01.cir.94.8.1834. [DOI] [PubMed] [Google Scholar]
  41. Helfant R. H., Pine R., Meister S. G., Feldman M. S., Trout R. G., Banka V. S. Nitroglycerin to unmask reversible asynergy. Correlation with post coronary bypass ventriculography. Circulation. 1974 Jul;50(1):108–113. doi: 10.1161/01.cir.50.1.108. [DOI] [PubMed] [Google Scholar]
  42. Herrero P., Staudenherz A., Walsh J. F., Gropler R. J., Bergmann S. R. Heterogeneity of myocardial perfusion provides the physiological basis of perfusable tissue index. J Nucl Med. 1995 Feb;36(2):320–327. [PubMed] [Google Scholar]
  43. Heyndrickx G. R., Millard R. W., McRitchie R. J., Maroko P. R., Vatner S. F. Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs. J Clin Invest. 1975 Oct;56(4):978–985. doi: 10.1172/JCI108178. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Horn H. R., Teichholz L. E., Cohn P. F., Herman M. V., Gorlin R. Augmentation of left ventricular contraction pattern in coronary artery disease by an inotropic catecholamine. The epinephrine ventriculogram. Circulation. 1974 Jun;49(6):1063–1071. doi: 10.1161/01.cir.49.6.1063. [DOI] [PubMed] [Google Scholar]
  45. Iida H., Rhodes C. G., de Silva R., Yamamoto Y., Araujo L. I., Maseri A., Jones T. Myocardial tissue fraction--correction for partial volume effects and measure of tissue viability. J Nucl Med. 1991 Nov;32(11):2169–2175. [PubMed] [Google Scholar]
  46. Kloner R. A., Przyklenk K., Patel B. Altered myocardial states. The stunned and hibernating myocardium. Am J Med. 1989 Jan 16;86(1A):14–22. doi: 10.1016/0002-9343(89)90005-3. [DOI] [PubMed] [Google Scholar]
  47. La Canna G., Alfieri O., Giubbini R., Gargano M., Ferrari R., Visioli O. Echocardiography during infusion of dobutamine for identification of reversibly dysfunction in patients with chronic coronary artery disease. J Am Coll Cardiol. 1994 Mar 1;23(3):617–626. doi: 10.1016/0735-1097(94)90745-5. [DOI] [PubMed] [Google Scholar]
  48. Lenfant C. NHLBI funding policies. Enhancing stability, predictability, and cost control. Circulation. 1994 Jul;90(1):1–1. doi: 10.1161/01.cir.90.1.1. [DOI] [PubMed] [Google Scholar]
  49. Liedtke A. J., Renstrom B., Nellis S. H., Hall J. L., Stanley W. C. Mechanical and metabolic functions in pig hearts after 4 days of chronic coronary stenosis. J Am Coll Cardiol. 1995 Sep;26(3):815–825. doi: 10.1016/0735-1097(95)00223-Q. [DOI] [PubMed] [Google Scholar]
  50. Madaras E. I., Barzilai B., Perez J. E., Sobel B. E., Miller J. G. Changes in myocardial backscatter throughout the cardiac cycle. Ultrason Imaging. 1983 Jul;5(3):229–239. doi: 10.1177/016173468300500303. [DOI] [PubMed] [Google Scholar]
  51. Marinho N. V., Keogh B. E., Costa D. C., Lammerstma A. A., Ell P. J., Camici P. G. Pathophysiology of chronic left ventricular dysfunction. New insights from the measurement of absolute myocardial blood flow and glucose utilization. Circulation. 1996 Feb 15;93(4):737–744. doi: 10.1161/01.cir.93.4.737. [DOI] [PubMed] [Google Scholar]
  52. Marzullo P., Parodi O., Reisenhofer B., Sambuceti G., Picano E., Distante A., Gimelli A., L'Abbate A. Value of rest thallium-201/technetium-99m sestamibi scans and dobutamine echocardiography for detecting myocardial viability. Am J Cardiol. 1993 Jan 15;71(2):166–172. doi: 10.1016/0002-9149(93)90733-s. [DOI] [PubMed] [Google Scholar]
  53. Matsuzaki M., Gallagher K. P., Kemper W. S., White F., Ross J., Jr Sustained regional dysfunction produced by prolonged coronary stenosis: gradual recovery after reperfusion. Circulation. 1983 Jul;68(1):170–182. doi: 10.1161/01.cir.68.1.170. [DOI] [PubMed] [Google Scholar]
  54. Meluzín J., Cerný J., Frélich M., Stetka F., Spinarová L., Popelová J., Stípal R. Prognostic value of the amount of dysfunctional but viable myocardium in revascularized patients with coronary artery disease and left ventricular dysfunction. Investigators of this Multicenter Study. J Am Coll Cardiol. 1998 Oct;32(4):912–920. doi: 10.1016/s0735-1097(98)00324-6. [DOI] [PubMed] [Google Scholar]
  55. Mertes H., Segar D. S., Johnson M., Ryan T., Sawada S. G., Feigenbaum H. Assessment of hibernating myocardium by dobutamine stimulation in a canine model. J Am Coll Cardiol. 1995 Nov 1;26(5):1348–1355. doi: 10.1016/0735-1097(95)00305-3. [DOI] [PubMed] [Google Scholar]
  56. Miller J. G., Pérez J. E., Sobel B. E. Ultrasonic characterization of myocardium. Prog Cardiovasc Dis. 1985 Sep-Oct;28(2):85–110. doi: 10.1016/0033-0620(85)90020-9. [DOI] [PubMed] [Google Scholar]
  57. Milunski M. R., Mohr G. A., Pérez J. E., Vered Z., Wear K. A., Gessler C. J., Sobel B. E., Miller J. G., Wickline S. A. Ultrasonic tissue characterization with integrated backscatter. Acute myocardial ischemia, reperfusion, and stunned myocardium in patients. Circulation. 1989 Sep;80(3):491–503. doi: 10.1161/01.cir.80.3.491. [DOI] [PubMed] [Google Scholar]
  58. Milunski M. R., Mohr G. A., Wear K. A., Sobel B. E., Miller J. G., Wickline S. A. Early identification with ultrasonic integrated backscatter of viable but stunned myocardium in dogs. J Am Coll Cardiol. 1989 Aug;14(2):462–471. doi: 10.1016/0735-1097(89)90203-9. [DOI] [PubMed] [Google Scholar]
  59. Nesto R. W., Cohn L. H., Collins J. J., Jr, Wynne J., Holman L., Cohn P. F. Inotropic contractile reserve: a useful predictor of increased 5 year survival and improved postoperative left ventricular function in patients with coronary artery disease and reduced ejection fraction. Am J Cardiol. 1982 Jul;50(1):39–44. doi: 10.1016/0002-9149(82)90006-6. [DOI] [PubMed] [Google Scholar]
  60. Pantely G. A., Malone S. A., Rhen W. S., Anselone C. G., Arai A., Bristow J., Bristow J. D. Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia. Circ Res. 1990 Dec;67(6):1481–1493. doi: 10.1161/01.res.67.6.1481. [DOI] [PubMed] [Google Scholar]
  61. Pasquet A., D'Hondt A. M., Melin J. A., Vanoverschelde J. L. Relation of ultrasonic tissue characterization with integrated backscatter to contractile reserve in chronic left ventricular ischemic dysfunction. Am J Cardiol. 1998 Jan 1;81(1):68–74. doi: 10.1016/s0002-9149(97)00861-8. [DOI] [PubMed] [Google Scholar]
  62. Pasquet A., Robert A., D'Hondt A. M., Dion R., Melin J. A., Vanoverschelde J. L. Prognostic value of myocardial ischemia and viability in patients with chronic left ventricular ischemic dysfunction. Circulation. 1999 Jul 13;100(2):141–148. doi: 10.1161/01.cir.100.2.141. [DOI] [PubMed] [Google Scholar]
  63. Perrone-Filardi P., Pace L., Prastaro M., Piscione F., Betocchi S., Squame F., Vezzuto P., Soricelli A., Indolfi C., Salvatore M. Dobutamine echocardiography predicts improvement of hypoperfused dysfunctional myocardium after revascularization in patients with coronary artery disease. Circulation. 1995 May 15;91(10):2556–2565. doi: 10.1161/01.cir.91.10.2556. [DOI] [PubMed] [Google Scholar]
  64. Perrone-Filardi P., Pace L., Prastaro M., Squame F., Betocchi S., Soricelli A., Piscione F., Indolfi C., Crisci T., Salvatore M. Assessment of myocardial viability in patients with chronic coronary artery disease. Rest-4-hour-24-hour 201Tl tomography versus dobutamine echocardiography. Circulation. 1996 Dec 1;94(11):2712–2719. doi: 10.1161/01.cir.94.11.2712. [DOI] [PubMed] [Google Scholar]
  65. Popio K. A., Gorlin R., Bechtel D., Levine J. A. Postextrasystolic potentiation as a predictor of potential myocardial viability: preoperative analyses compared with studies after coronary bypass surgery. Am J Cardiol. 1977 Jun;39(7):944–953. doi: 10.1016/s0002-9149(77)80206-3. [DOI] [PubMed] [Google Scholar]
  66. Qureshi U., Nagueh S. F., Afridi I., Vaduganathan P., Blaustein A., Verani M. S., Winters W. L., Jr, Zoghbi W. A. Dobutamine echocardiography and quantitative rest-redistribution 201Tl tomography in myocardial hibernation. Relation of contractile reserve to 201Tl uptake and comparative prediction of recovery of function. Circulation. 1997 Feb 4;95(3):626–635. doi: 10.1161/01.cir.95.3.626. [DOI] [PubMed] [Google Scholar]
  67. Rahimtoola S. H. The hibernating myocardium. Am Heart J. 1989 Jan;117(1):211–221. doi: 10.1016/0002-8703(89)90685-6. [DOI] [PubMed] [Google Scholar]
  68. Ross J., Jr Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation. Circulation. 1991 Mar;83(3):1076–1083. doi: 10.1161/01.cir.83.3.1076. [DOI] [PubMed] [Google Scholar]
  69. Sambuceti G., Parodi O., Marzullo P., Giorgetti A., Fusani L., Puccini G., Salvadori P., L'Abbate A. Regional myocardial blood flow in stable angina pectoris associated with isolated significant narrowing of either the left anterior descending or left circumflex coronary artery. Am J Cardiol. 1993 Nov 1;72(14):990–994. doi: 10.1016/0002-9149(93)90850-c. [DOI] [PubMed] [Google Scholar]
  70. Schnittger I., Vieli A., Heiserman J. E., Director B. A., Billingham M. E., Ellis S. G., Kernoff R. S., Takamoto T., Popp R. L. Ultrasonic tissue characterization: detection of acute myocardial ischemia in dogs. Circulation. 1985 Jul;72(1):193–199. doi: 10.1161/01.cir.72.1.193. [DOI] [PubMed] [Google Scholar]
  71. Schulz R., Guth B. D., Pieper K., Martin C., Heusch G. Recruitment of an inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery. A model of short-term hibernation. Circ Res. 1992 Jun;70(6):1282–1295. doi: 10.1161/01.res.70.6.1282. [DOI] [PubMed] [Google Scholar]
  72. Schulz R., Rose J., Martin C., Brodde O. E., Heusch G. Development of short-term myocardial hibernation. Its limitation by the severity of ischemia and inotropic stimulation. Circulation. 1993 Aug;88(2):684–695. doi: 10.1161/01.cir.88.2.684. [DOI] [PubMed] [Google Scholar]
  73. Senior R., Glenville B., Basu S., Sridhara B. S., Anagnostou E., Stanbridge R., Edmondson S. J., Handler C. E., Raftery E. B., Lahiri A. Dobutamine echocardiography and thallium-201 imaging predict functional improvement after revascularisation in severe ischaemic left ventricular dysfunction. Br Heart J. 1995 Oct;74(4):358–364. doi: 10.1136/hrt.74.4.358. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Shen Y. T., Vatner S. F. Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs. Hibernation versus stunning? Circ Res. 1995 Mar;76(3):479–488. doi: 10.1161/01.res.76.3.479. [DOI] [PubMed] [Google Scholar]
  75. Sklenar J., Ismail S., Villanueva F. S., Goodman N. C., Glasheen W. P., Kaul S. Dobutamine echocardiography for determining the extent of myocardial salvage after reperfusion. An experimental evaluation. Circulation. 1994 Sep;90(3):1502–1512. doi: 10.1161/01.cir.90.3.1502. [DOI] [PubMed] [Google Scholar]
  76. Smith S. C., Jr AHA president's letter. Circulation. 1995 Jul 1;92(1):1–1. [PubMed] [Google Scholar]
  77. Smith S. C., Jr AHA president's letter. Circulation. 1995 Jul 1;92(1):1–1. [PubMed] [Google Scholar]
  78. Sun K. T., Czernin J., Krivokapich J., Lau Y. K., Böttcher M., Maurer G., Phelps M. E., Schelbert H. R. Effects of dobutamine stimulation on myocardial blood flow, glucose metabolism, and wall motion in normal and dysfunctional myocardium. Circulation. 1996 Dec 15;94(12):3146–3154. doi: 10.1161/01.cir.94.12.3146. [DOI] [PubMed] [Google Scholar]
  79. Tamaki N., Yonekura Y., Yamashita K., Saji H., Magata Y., Senda M., Konishi Y., Hirata K., Ban T., Konishi J. Positron emission tomography using fluorine-18 deoxyglucose in evaluation of coronary artery bypass grafting. Am J Cardiol. 1989 Oct 15;64(14):860–865. doi: 10.1016/0002-9149(89)90832-1. [DOI] [PubMed] [Google Scholar]
  80. Tillisch J., Brunken R., Marshall R., Schwaiger M., Mandelkern M., Phelps M., Schelbert H. Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med. 1986 Apr 3;314(14):884–888. doi: 10.1056/NEJM198604033141405. [DOI] [PubMed] [Google Scholar]
  81. Vandenberg B. F., Stuhlmuller J. E., Rath L., Kerber R. E., Collins S. M., Melton H. E., Skorton D. J. Diagnosis of recent myocardial infarction with quantitative backscatter imaging: preliminary studies. J Am Soc Echocardiogr. 1991 Jan-Feb;4(1):10–18. doi: 10.1016/s0894-7317(14)80155-7. [DOI] [PubMed] [Google Scholar]
  82. Vanoverschelde J. L., D'Hondt A. M., Marwick T., Gerber B. L., De Kock M., Dion R., Wijns W., Melin J. A. Head-to-head comparison of exercise-redistribution-reinjection thallium single-photon emission computed tomography and low dose dobutamine echocardiography for prediction of reversibility of chronic left ventricular ischemic dysfunction. J Am Coll Cardiol. 1996 Aug;28(2):432–442. doi: 10.1016/0735-1097(96)00167-2. [DOI] [PubMed] [Google Scholar]
  83. Vanoverschelde J. L., Wijns W., Borgers M., Heyndrickx G., Depré C., Flameng W., Melin J. A. Chronic myocardial hibernation in humans. From bedside to bench. Circulation. 1997 Apr 1;95(7):1961–1971. doi: 10.1161/01.cir.95.7.1961. [DOI] [PubMed] [Google Scholar]
  84. Vanoverschelde J. L., Wijns W., Depré C., Essamri B., Heyndrickx G. R., Borgers M., Bol A., Melin J. A. Mechanisms of chronic regional postischemic dysfunction in humans. New insights from the study of noninfarcted collateral-dependent myocardium. Circulation. 1993 May;87(5):1513–1523. doi: 10.1161/01.cir.87.5.1513. [DOI] [PubMed] [Google Scholar]
  85. Vatner S. F. Correlation between acute reductions in myocardial blood flow and function in conscious dogs. Circ Res. 1980 Aug;47(2):201–207. doi: 10.1161/01.res.47.2.201. [DOI] [PubMed] [Google Scholar]
  86. Villanueva F. S., Jankowski R. J., Klibanov S., Pina M. L., Alber S. M., Watkins S. C., Brandenburger G. H., Wagner W. R. Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation. 1998 Jul 7;98(1):1–5. doi: 10.1161/01.cir.98.1.1. [DOI] [PubMed] [Google Scholar]
  87. Villanueva F. S., Jankowski R. J., Klibanov S., Pina M. L., Alber S. M., Watkins S. C., Brandenburger G. H., Wagner W. R. Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation. 1998 Jul 7;98(1):1–5. doi: 10.1161/01.cir.98.1.1. [DOI] [PubMed] [Google Scholar]
  88. Vitale D. F., Bonow R. O., Gerundo G., Pelaggi N., Lauria G., Leosco D., Coltorti F., Bordini C., Rengo C., Rengo F. Alterations in ultrasonic backscatter during exercise-induced myocardial ischemia in humans. Circulation. 1995 Sep 15;92(6):1452–1457. doi: 10.1161/01.cir.92.6.1452. [DOI] [PubMed] [Google Scholar]
  89. Wickline S. A., Thomas L. J., 3rd, Miller J. G., Sobel B. E., Perez J. E. A relationship between ultrasonic integrated backscatter and myocardial contractile function. J Clin Invest. 1985 Dec;76(6):2151–2160. doi: 10.1172/JCI112221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Wickline S. A., Thomas L. J., 3rd, Miller J. G., Sobel B. E., Perez J. E. Sensitive detection of the effects of reperfusion on myocardium by ultrasonic tissue characterization with integrated backscatter. Circulation. 1986 Aug;74(2):389–400. doi: 10.1161/01.cir.74.2.389. [DOI] [PubMed] [Google Scholar]
  91. Wickline S. A., Thomas L. J., 3rd, Miller J. G., Sobel B. E., Pérez J. E. The dependence of myocardial ultrasonic integrated backscatter on contractile performance. Circulation. 1985 Jul;72(1):183–192. doi: 10.1161/01.cir.72.1.183. [DOI] [PubMed] [Google Scholar]
  92. Williams M. J., Odabashian J., Lauer M. S., Thomas J. D., Marwick T. H. Prognostic value of dobutamine echocardiography in patients with left ventricular dysfunction. J Am Coll Cardiol. 1996 Jan;27(1):132–139. doi: 10.1016/0735-1097(95)00393-2. [DOI] [PubMed] [Google Scholar]
  93. de Silva R., Yamamoto Y., Rhodes C. G., Iida H., Nihoyannopoulos P., Davies G. J., Lammertsma A. A., Jones T., Maseri A. Preoperative prediction of the outcome of coronary revascularization using positron emission tomography. Circulation. 1992 Dec;86(6):1738–1742. doi: 10.1161/01.cir.86.6.1738. [DOI] [PubMed] [Google Scholar]
  94. deFilippi C. R., Willett D. L., Irani W. N., Eichhorn E. J., Velasco C. E., Grayburn P. A. Comparison of myocardial contrast echocardiography and low-dose dobutamine stress echocardiography in predicting recovery of left ventricular function after coronary revascularization in chronic ischemic heart disease. Circulation. 1995 Nov 15;92(10):2863–2868. doi: 10.1161/01.cir.92.10.2863. [DOI] [PubMed] [Google Scholar]

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