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. 1998 Jul;43(Suppl 1):S56–S60. doi: 10.1136/gut.43.2008.s56

The life and death of Helicobacter pylori

D Scott, D Weeks, K Melchers, G Sachs
PMCID: PMC1766596  PMID: 9764042

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Figure 1 .

Figure 1

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Comparison of the pH optimum of urease external to H pylori and urease in intact organisms illustrating the 10-fold activation in intact organisms seen between pH 6.5 and 5.5. 


Figure 2 .

Figure 2

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Comparison of protein labelling as a function of time using 35S-methionine to label the protein. The four lanes on the right represent proteins synthesised in intact H pylori and the four lanes on the left the medium in which these were suspended. Significant quantities of labelled protein only appear in the medium after about 16 hours of incubation. The protein in the medium shows the same relative labelling pattern as in the whole bacteria. This image is typical of at least three experiments. SOD, superoxide dismutase. 


Figure 3 .

Figure 3

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Comparison of the pH range over which H pylori survives to the pH range at which it grows or synthesises protein in the absence of urea. On the figure we indicate the range for which antibiotic sensitivity is expected and illustrate the theoretical effect of proton pump inhibition (PPI) on the population distribution of H pylori between dividing and non-dividing organisms. A, amoxycillin; C, clarithromycin. 


Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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