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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 2000 Nov;59(Suppl 1):i32–i35. doi: 10.1136/ard.59.suppl_1.i32

Efficacy and toxicity of old and new disease modifying antirheumatic drugs

P Tugwell, V Welch, M Suarez-Almazor, B Shea, G Wells
PMCID: PMC1766628  PMID: 11053083

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Figure 1  .

Figure 1  

Seriousness of outcome in rheumatoid arthritis: What are the "7Ds"?

Figure 2  .

Figure 2  

Hierarchy of evidence.

Figure 3  .

Figure 3  

Example of meta-analysis—sulfasalazine: tender joint count.

Figure 4  .

Figure 4  

Summary of DMARD reviews on tender joint count.

Figure 5  .

Figure 5  

Summary of DMARD reviews on swollen joint count.

Figure 6  .

Figure 6  

Sample consumer summary from The Arthritis Society web site (www.arthritis.ca).

Figure 7  .

Figure 7  

Method of comparing efficacy and toxicity developed by Felson DT et al.12

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Edmonds J. P., Scott D. L., Furst D. E., Paulus H. E. New classification of antirheumatic drugs. The evolution of a concept. J Rheumatol. 1993 Mar;20(3):585–587. [PubMed] [Google Scholar]
  2. Farr M., Waterhouse L., Johnson A. E., Kitas G. D., Jubb R. W., Bacon P. A. A double-blind controlled study comparing sulphasalazine with placebo in rheumatoid factor (RF)-negative rheumatoid arthritis. Clin Rheumatol. 1995 Sep;14(5):531–536. doi: 10.1007/BF02208150. [DOI] [PubMed] [Google Scholar]
  3. Felson D. T., Anderson J. J., Meenan R. F. Use of short-term efficacy/toxicity tradeoffs to select second-line drugs in rheumatoid arthritis. A metaanalysis of published clinical trials. Arthritis Rheum. 1992 Oct;35(10):1117–1125. doi: 10.1002/art.1780351003. [DOI] [PubMed] [Google Scholar]
  4. Hannonen P., Möttönen T., Hakola M., Oka M. Sulfasalazine in early rheumatoid arthritis. A 48-week double-blind, prospective, placebo-controlled study. Arthritis Rheum. 1993 Nov;36(11):1501–1509. doi: 10.1002/art.1780361104. [DOI] [PubMed] [Google Scholar]
  5. Pullar T., Hunter J. A., Capell H. A. Sulphasalazine in rheumatoid arthritis: a double blind comparison of sulphasalazine with placebo and sodium aurothiomalate. Br Med J (Clin Res Ed) 1983 Oct 15;287(6399):1102–1104. doi: 10.1136/bmj.287.6399.1102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Smolen J. S., Kalden J. R., Scott D. L., Rozman B., Kvien T. K., Larsen A., Loew-Friedrich I., Oed C., Rosenburg R. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group. Lancet. 1999 Jan 23;353(9149):259–266. doi: 10.1016/s0140-6736(98)09403-3. [DOI] [PubMed] [Google Scholar]
  7. Verhoeven A. C., Boers M., Tugwell P. Combination therapy in rheumatoid arthritis: updated systematic review. Br J Rheumatol. 1998 Jun;37(6):612–619. doi: 10.1093/rheumatology/37.6.612. [DOI] [PubMed] [Google Scholar]
  8. Williams H. J., Ward J. R., Dahl S. L., Clegg D. O., Willkens R. F., Oglesby T., Weisman M. H., Schlegel S., Michaels R. M., Luggen M. E. A controlled trial comparing sulfasalazine, gold sodium thiomalate, and placebo in rheumatoid arthritis. Arthritis Rheum. 1988 Jun;31(6):702–713. doi: 10.1002/art.1780310602. [DOI] [PubMed] [Google Scholar]

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