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. 2000 Dec;47(Suppl 4):iv49–iv51. doi: 10.1136/gut.47.suppl_4.iv49

Stress and neuroimmune regulation of gut mucosal function

J Santos, M Perdue
PMCID: PMC1766810  PMID: 11076912

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Figure 1  .

Figure 1  

Regulation of intestinal secretion and permeability. SP, substance P; CRH, corticotrophin releasing hormone; ACh, acetylcholine; NA, noradrenaline; NO, nitric oxide; AVP, arginine vasopressin; 5-HT, 5-hydroxytryptamine; GABA, gamma amino butyric acid; ATCH, adrenocorticotrophic hormone; AGT, angiotensin; PVN, paraventricular nucleus.

Figure 2  .

Figure 2  

Adaptive responses to stress. GALT, gut associated lymphoid tissue.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baird A. W., Cuthbert A. W., MacVinish L. J. Type 1 hypersensitivity reactions in reconstructed tissues using syngeneic cell types. Br J Pharmacol. 1987 Aug;91(4):857–869. doi: 10.1111/j.1476-5381.1987.tb11285.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barclay G. R., Turnberg L. A. Effect of psychological stress on salt and water transport in the human jejunum. Gastroenterology. 1987 Jul;93(1):91–97. doi: 10.1016/0016-5085(87)90319-2. [DOI] [PubMed] [Google Scholar]
  3. Berin M. C., Kiliaan A. J., Yang P. C., Groot J. A., Kitamura Y., Perdue M. H. The influence of mast cells on pathways of transepithelial antigen transport in rat intestine. J Immunol. 1998 Sep 1;161(5):2561–2566. [PubMed] [Google Scholar]
  4. Crowe S. E., Perdue M. H. Gastrointestinal food hypersensitivity: basic mechanisms of pathophysiology. Gastroenterology. 1992 Sep;103(3):1075–1095. doi: 10.1016/0016-5085(92)90047-3. [DOI] [PubMed] [Google Scholar]
  5. Crowe S. E., Sestini P., Perdue M. H. Allergic reactions of rat jejunal mucosa. Ion transport responses to luminal antigen and inflammatory mediators. Gastroenterology. 1990 Jul;99(1):74–82. doi: 10.1016/0016-5085(90)91232-u. [DOI] [PubMed] [Google Scholar]
  6. Kiliaan A. J., Saunders P. R., Bijlsma P. B., Berin M. C., Taminiau J. A., Groot J. A., Perdue M. H. Stress stimulates transepithelial macromolecular uptake in rat jejunum. Am J Physiol. 1998 Nov;275(5 Pt 1):G1037–G1044. doi: 10.1152/ajpgi.1998.275.5.G1037. [DOI] [PubMed] [Google Scholar]
  7. MacQueen G., Marshall J., Perdue M., Siegel S., Bienenstock J. Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II. Science. 1989 Jan 6;243(4887):83–85. doi: 10.1126/science.2911721. [DOI] [PubMed] [Google Scholar]
  8. Mendeloff A. I., Monk M., Siegel C. I., Lilienfeld A. Illness experience and life stresses in patients with irritable colon and with ulcerative colitis. An epidemiologic study of ulcerative colitis and regional enteritis in Baltimore, 1960-1964. N Engl J Med. 1970 Jan 1;282(1):14–17. doi: 10.1056/NEJM197001012820104. [DOI] [PubMed] [Google Scholar]
  9. Perdue M. H., Masson S., Wershil B. K., Galli S. J. Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. Correction of the diminished secretory response in genetically mast cell-deficient W/Wv mice by bone marrow transplantation. J Clin Invest. 1991 Feb;87(2):687–693. doi: 10.1172/JCI115047. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Santos J., Perdue M. H. Immunological regulation of intestinal epithelial transport. Digestion. 1998 Jul-Aug;59(4):404–408. doi: 10.1159/000007498. [DOI] [PubMed] [Google Scholar]
  11. Santos J., Saperas E., Nogueiras C., Mourelle M., Antolín M., Cadahia A., Malagelada J. R. Release of mast cell mediators into the jejunum by cold pain stress in humans. Gastroenterology. 1998 Apr;114(4):640–648. doi: 10.1016/s0016-5085(98)70577-3. [DOI] [PubMed] [Google Scholar]
  12. Saunders P. R., Kosecka U., McKay D. M., Perdue M. H. Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine. Am J Physiol. 1994 Nov;267(5 Pt 1):G794–G799. doi: 10.1152/ajpgi.1994.267.5.G794. [DOI] [PubMed] [Google Scholar]
  13. Stead R. H., Tomioka M., Quinonez G., Simon G. T., Felten S. Y., Bienenstock J. Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves. Proc Natl Acad Sci U S A. 1987 May;84(9):2975–2979. doi: 10.1073/pnas.84.9.2975. [DOI] [PMC free article] [PubMed] [Google Scholar]

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