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. 2000 Dec;47(Suppl 4):iv23–iv25. doi: 10.1136/gut.47.suppl_4.iv23

Postjunctional electrical mechanisms of enteric neurotransmission

K Sanders
PMCID: PMC1766825  PMID: 11076900

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Figure 1  .

Figure 1  

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Organisation of electrical activity in phasic gastrointestinal muscles. ICC, interstitial cells of Cajal.

Figure 2  .

Figure 2  

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Acetylcholine (ACh), tachykinins (TK), and excitatory hormones activate non-selective cation channels. NSCC, non-selective cation current; Vas, vasopressin; SR, sarcoplasmic reticulum; NK2, neurokinin 2. 

Figure 3  .

Figure 3  

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Inhibitory agonists activate potassium channels in gastrointestinal smooth muscles. VIP, vasoactive intestinal peptide; cAMP, cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate; SK, small conductance Ca2+ activated K+ channel; SR, sarcoplasmic reticulum; P2Y, purinergic receptor type P2Y; DR, delayed rectifier; BK, large conductance Ca2+ activated K+ channel.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carl A., Lee H. K., Sanders K. M. Regulation of ion channels in smooth muscles by calcium. Am J Physiol. 1996 Jul;271(1 Pt 1):C9–34. doi: 10.1152/ajpcell.1996.271.1.C9. [DOI] [PubMed] [Google Scholar]
  2. Fleischmann B. K., Murray R. K., Kotlikoff M. I. Voltage window for sustained elevation of cytosolic calcium in smooth muscle cells. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11914–11918. doi: 10.1073/pnas.91.25.11914. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Inoue R., Isenberg G. Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein. Am J Physiol. 1990 Jun;258(6 Pt 1):C1173–C1178. doi: 10.1152/ajpcell.1990.258.6.C1173. [DOI] [PubMed] [Google Scholar]
  4. Koh S. D., Campbell J. D., Carl A., Sanders K. M. Nitric oxide activates multiple potassium channels in canine colonic smooth muscle. J Physiol. 1995 Dec 15;489(Pt 3):735–743. doi: 10.1113/jphysiol.1995.sp021087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Koh S. D., Dick G. M., Sanders K. M. Small-conductance Ca(2+)-dependent K+ channels activated by ATP in murine colonic smooth muscle. Am J Physiol. 1997 Dec;273(6 Pt 1):C2010–C2021. doi: 10.1152/ajpcell.1997.273.6.C2010. [DOI] [PubMed] [Google Scholar]
  6. Koh S. D., Sanders K. M., Carl A. Regulation of smooth muscle delayed rectifier K+ channels by protein kinase A. Pflugers Arch. 1996 Jul;432(3):401–412. doi: 10.1007/s004240050151. [DOI] [PubMed] [Google Scholar]
  7. Koh S. D., Sanders K. M. Modulation of Ca2+ current in canine colonic myocytes by cyclic nucleotide-dependent mechanisms. Am J Physiol. 1996 Sep;271(3 Pt 1):C794–C803. doi: 10.1152/ajpcell.1996.271.3.C794. [DOI] [PubMed] [Google Scholar]
  8. Lee H. K., Shuttleworth C. W., Sanders K. M. Tachykinins activate nonselective cation currents in canine colonic myocytes. Am J Physiol. 1995 Dec;269(6 Pt 1):C1394–C1401. doi: 10.1152/ajpcell.1995.269.6.C1394. [DOI] [PubMed] [Google Scholar]
  9. Nelson M. T., Cheng H., Rubart M., Santana L. F., Bonev A. D., Knot H. J., Lederer W. J. Relaxation of arterial smooth muscle by calcium sparks. Science. 1995 Oct 27;270(5236):633–637. doi: 10.1126/science.270.5236.633. [DOI] [PubMed] [Google Scholar]
  10. Sanders K. M. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology. 1996 Aug;111(2):492–515. doi: 10.1053/gast.1996.v111.pm8690216. [DOI] [PubMed] [Google Scholar]
  11. Trautwein W., Hescheler J. Regulation of cardiac L-type calcium current by phosphorylation and G proteins. Annu Rev Physiol. 1990;52:257–274. doi: 10.1146/annurev.ph.52.030190.001353. [DOI] [PubMed] [Google Scholar]
  12. Vogalis F., Goyal R. K. Activation of small conductance Ca(2+)-dependent K+ channels by purinergic agonists in smooth muscle cells of the mouse ileum. J Physiol. 1997 Aug 1;502(Pt 3):497–508. doi: 10.1111/j.1469-7793.1997.497bj.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Vogalis F., Publicover N. G., Hume J. R., Sanders K. M. Relationship between calcium current and cytosolic calcium in canine gastric smooth muscle cells. Am J Physiol. 1991 May;260(5 Pt 1):C1012–C1018. doi: 10.1152/ajpcell.1991.260.5.C1012. [DOI] [PubMed] [Google Scholar]
  14. Zhang L., Bonev A. D., Mawe G. M., Nelson M. T. Protein kinase A mediates activation of ATP-sensitive K+ currents by CGRP in gallbladder smooth muscle. Am J Physiol. 1994 Sep;267(3 Pt 1):G494–G499. doi: 10.1152/ajpgi.1994.267.3.G494. [DOI] [PubMed] [Google Scholar]

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