Abstract
Psoriasis is a common chronic, recurrent, immune mediated disease of the skin and joints. It can have a significant negative impact on the physical, emotional, and, psychosocial wellbeing of affected patients. Psoriasis is found worldwide but the prevalence varies among different ethnic groups. It has a strong genetic component but environmental factors such as infections can play an important role in the presentation of disease. There are several clinical cutaneous manifestations of psoriasis but most commonly the disease presents as chronic, symmetrical, erythematous, scaling papules and plaques. The epidemiology, clinical features, and impact on quality of life of psoriasis are reviewed.
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- Asumalahti Kati, Ameen Mahreen, Suomela Sari, Hagforsen Eva, Michaëlsson Gerd, Evans Julie, Munro Margo, Veal Colin, Allen Michael, Leman Joyce. Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis. J Invest Dermatol. 2003 Apr;120(4):627–632. doi: 10.1046/j.1523-1747.2003.12094.x. [DOI] [PubMed] [Google Scholar]
- Best W. R., Becktel J. M., Singleton J. W. Rederived values of the eight coefficients of the Crohn's Disease Activity Index (CDAI). Gastroenterology. 1979 Oct;77(4 Pt 2):843–846. [PubMed] [Google Scholar]
- Burch P. R., Rowell N. R. Mode of inheritance in psoriasis. Arch Dermatol. 1981 May;117(5):251–252. [PubMed] [Google Scholar]
- Capon F., Novelli G., Semprini S., Clementi M., Nudo M., Vultaggio P., Mazzanti C., Gobello T., Botta A., Fabrizi G. Searching for psoriasis susceptibility genes in Italy: genome scan and evidence for a new locus on chromosome 1. J Invest Dermatol. 1999 Jan;112(1):32–35. doi: 10.1046/j.1523-1747.1999.00471.x. [DOI] [PubMed] [Google Scholar]
- Capon F., Semprini S., Dallapiccola B., Novelli G. Evidence for interaction between psoriasis-susceptibility loci on chromosomes 6p21 and 1q21. Am J Hum Genet. 1999 Dec;65(6):1798–1800. doi: 10.1086/302653. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chen Suephy C., Bayoumi Ahmed M., Soon Seaver L., Aftergut Kent, Cruz Ponciano, Sexton Shenara A., McCall Calvin O., Goldstein Mary K. A catalog of dermatology utilities: a measure of the burden of skin diseases. J Investig Dermatol Symp Proc. 2004 Mar;9(2):160–168. doi: 10.1046/j.1087-0024.2003.09112.x. [DOI] [PubMed] [Google Scholar]
- De Korte John, Mombers Femke M. C., Sprangers Mirjam A. G., Bos Jan D. The suitability of quality-of-life questionnaires for psoriasis research: a systematic literature review. Arch Dermatol. 2002 Sep;138(9):1221–1227. doi: 10.1001/archderm.138.9.1221. [DOI] [PubMed] [Google Scholar]
- Enlund F., Samuelsson L., Enerbäck C., Inerot A., Wahlström J., Yhr M., Torinsson A., Martinsson T., Swanbeck G. Analysis of three suggested psoriasis susceptibility loci in a large Swedish set of families: confirmation of linkage to chromosome 6p (HLA region), and to 17q, but not to 4q. Hum Hered. 1999 Jan;49(1):2–8. doi: 10.1159/000022832. [DOI] [PubMed] [Google Scholar]
- Enlund F., Samuelsson L., Enerbäck C., Inerot A., Wahlström J., Yhr M., Torinsson A., Riley J., Swanbeck G., Martinsson T. Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden. Eur J Hum Genet. 1999 Oct-Nov;7(7):783–790. doi: 10.1038/sj.ejhg.5200365. [DOI] [PubMed] [Google Scholar]
- Farber E. M., Nall M. L. The natural history of psoriasis in 5,600 patients. Dermatologica. 1974;148(1):1–18. doi: 10.1159/000251595. [DOI] [PubMed] [Google Scholar]
- Felson D. T., Anderson J. J., Boers M., Bombardier C., Furst D., Goldsmith C., Katz L. M., Lightfoot R., Jr, Paulus H., Strand V. American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum. 1995 Jun;38(6):727–735. doi: 10.1002/art.1780380602. [DOI] [PubMed] [Google Scholar]
- Ferrándiz Carlos, Pujol Ramon M., García-Patos Vicente, Bordas Xavier, Smandía Joan A. Psoriasis of early and late onset: a clinical and epidemiologic study from Spain. J Am Acad Dermatol. 2002 Jun;46(6):867–873. doi: 10.1067/mjd.2002.120470. [DOI] [PubMed] [Google Scholar]
- Finlay A. Y., Coles E. C. The effect of severe psoriasis on the quality of life of 369 patients. Br J Dermatol. 1995 Feb;132(2):236–244. doi: 10.1111/j.1365-2133.1995.tb05019.x. [DOI] [PubMed] [Google Scholar]
- Finlay A. Y., Coles E. C. The effect of severe psoriasis on the quality of life of 369 patients. Br J Dermatol. 1995 Feb;132(2):236–244. doi: 10.1111/j.1365-2133.1995.tb05019.x. [DOI] [PubMed] [Google Scholar]
- Finlay A. Y., Kelly S. E. Psoriasis--an index of disability. Clin Exp Dermatol. 1987 Jan;12(1):8–11. doi: 10.1111/j.1365-2230.1987.tb01844.x. [DOI] [PubMed] [Google Scholar]
- Finlay A. Y., Kelly S. E. Psoriasis--an index of disability. Clin Exp Dermatol. 1987 Jan;12(1):8–11. doi: 10.1111/j.1365-2230.1987.tb01844.x. [DOI] [PubMed] [Google Scholar]
- Fortune D. G., Main C. J., O'Sullivan T. M., Griffiths C. E. Assessing illness-related stress in psoriasis: the psychometric properties of the Psoriasis Life Stress Inventory. J Psychosom Res. 1997 May;42(5):467–475. doi: 10.1016/s0022-3999(97)00036-6. [DOI] [PubMed] [Google Scholar]
- Fortune D. G., Richards H. L., Kirby B., Bowcock S., Main C. J., Griffiths C. E. M. A cognitive-behavioural symptom management programme as an adjunct in psoriasis therapy. Br J Dermatol. 2002 Mar;146(3):458–465. doi: 10.1046/j.1365-2133.2002.04622.x. [DOI] [PubMed] [Google Scholar]
- Fortune D. G., Richards H. L., Main C. J., Griffiths C. E. What patients with psoriasis believe about their condition. J Am Acad Dermatol. 1998 Aug;39(2 Pt 1):196–201. doi: 10.1016/s0190-9622(98)70074-x. [DOI] [PubMed] [Google Scholar]
- Fortune Donal G., Richards Helen L., Kirby Brian, McElhone Kathleen, Markham Trevor, Rogers Sarah, Main Chris J., Griffiths Christopher E. M. Psychological distress impairs clearance of psoriasis in patients treated with photochemotherapy. Arch Dermatol. 2003 Jun;139(6):752–756. doi: 10.1001/archderm.139.6.752. [DOI] [PubMed] [Google Scholar]
- Ginsburg I. H., Link B. G. Feelings of stigmatization in patients with psoriasis. J Am Acad Dermatol. 1989 Jan;20(1):53–63. doi: 10.1016/s0190-9622(89)70007-4. [DOI] [PubMed] [Google Scholar]
- Green A. C. Australian Aborigines and psoriasis. Australas J Dermatol. 1984 Apr;25(1):18–24. doi: 10.1111/j.1440-0960.1984.tb00618.x. [DOI] [PubMed] [Google Scholar]
- Gupta M. A., Schork N. J., Gupta A. K., Kirkby S., Ellis C. N. Suicidal ideation in psoriasis. Int J Dermatol. 1993 Mar;32(3):188–190. doi: 10.1111/j.1365-4362.1993.tb02790.x. [DOI] [PubMed] [Google Scholar]
- Henseler T., Christophers E. Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris. J Am Acad Dermatol. 1985 Sep;13(3):450–456. doi: 10.1016/s0190-9622(85)70188-0. [DOI] [PubMed] [Google Scholar]
- Irvine E. J., Feagan B., Rochon J., Archambault A., Fedorak R. N., Groll A., Kinnear D., Saibil F., McDonald J. W. Quality of life: a valid and reliable measure of therapeutic efficacy in the treatment of inflammatory bowel disease. Canadian Crohn's Relapse Prevention Trial Study Group. Gastroenterology. 1994 Feb;106(2):287–296. doi: 10.1016/0016-5085(94)90585-1. [DOI] [PubMed] [Google Scholar]
- Jorgensen C., Bressot N., Bologna C., Sany J. Dysregulation of the hypothalamo-pituitary axis in rheumatoid arthritis. J Rheumatol. 1995 Oct;22(10):1829–1833. [PubMed] [Google Scholar]
- Kirby B., Fortune D. G., Bhushan M., Chalmers R. J., Griffiths C. E. The Salford Psoriasis Index: an holistic measure of psoriasis severity. Br J Dermatol. 2000 Apr;142(4):728–732. doi: 10.1046/j.1365-2133.2000.03418.x. [DOI] [PubMed] [Google Scholar]
- Kirby B., Richards H. L., Woo P., Hindle E., Main C. J., Griffiths C. E. Physical and psychologic measures are necessary to assess overall psoriasis severity. J Am Acad Dermatol. 2001 Jul;45(1):72–76. doi: 10.1067/mjd.2001.114592. [DOI] [PubMed] [Google Scholar]
- Krueger G. G., Feldman S. R., Camisa C., Duvic M., Elder J. T., Gottlieb A. B., Koo J., Krueger J. G., Lebwohl M., Lowe N. Two considerations for patients with psoriasis and their clinicians: what defines mild, moderate, and severe psoriasis? What constitutes a clinically significant improvement when treating psoriasis? J Am Acad Dermatol. 2000 Aug;43(2 Pt 1):281–285. doi: 10.1067/mjd.2000.106374. [DOI] [PubMed] [Google Scholar]
- LOMHOLT G. PREVALENCE OF SKIN DISEASES IN A POPULATION; A CENSUS STUDY FROM THE FAROE ISLANDS. Dan Med Bull. 1964 Feb;11:1–7. [PubMed] [Google Scholar]
- Lee Y. A., Rüschendorf F., Windemuth C., Schmitt-Egenolf M., Stadelmann A., Nürnberg G., Ständer M., Wienker T. F., Reis A., Traupe H. Genomewide scan in german families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13. Am J Hum Genet. 2000 Sep 13;67(4):1020–1024. doi: 10.1086/303075. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lewis Victoria, Finlay Andrew Y. 10 years experience of the Dermatology Life Quality Index (DLQI). J Investig Dermatol Symp Proc. 2004 Mar;9(2):169–180. doi: 10.1111/j.1087-0024.2004.09113.x. [DOI] [PubMed] [Google Scholar]
- Martin B. A., Chalmers R. J., Telfer N. R. How great is the risk of further psoriasis following a single episode of acute guttate psoriasis? Arch Dermatol. 1996 Jun;132(6):717–718. doi: 10.1001/archderm.1996.03890300147032. [DOI] [PubMed] [Google Scholar]
- Matthews D., Fry L., Powles A., Weber J., McCarthy M., Fisher E., Davies K., Williamson R. Evidence that a locus for familial psoriasis maps to chromosome 4q. Nat Genet. 1996 Oct;14(2):231–233. doi: 10.1038/ng1096-231. [DOI] [PubMed] [Google Scholar]
- McKenna S. P., Cook S. A., Whalley D., Doward L. C., Richards H. L., Griffiths C. E. M., Van Assche D. Development of the PSORIQoL, a psoriasis-specific measure of quality of life designed for use in clinical practice and trials. Br J Dermatol. 2003 Aug;149(2):323–331. doi: 10.1046/j.1365-2133.2003.05492.x. [DOI] [PubMed] [Google Scholar]
- McKenna S. P., Doward L. C., Whalley D., Tennant A., Emery P., Veale D. J. Development of the PsAQoL: a quality of life instrument specific to psoriatic arthritis. Ann Rheum Dis. 2004 Feb;63(2):162–169. doi: 10.1136/ard.2003.006296. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nair R. P., Henseler T., Jenisch S., Stuart P., Bichakjian C. K., Lenk W., Westphal E., Guo S. W., Christophers E., Voorhees J. J. Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan. Hum Mol Genet. 1997 Aug;6(8):1349–1356. doi: 10.1093/hmg/6.8.1349. [DOI] [PubMed] [Google Scholar]
- Nair R. P., Stuart P., Henseler T., Jenisch S., Chia N. V., Westphal E., Schork N. J., Kim J., Lim H. W., Christophers E. Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C. Am J Hum Genet. 2000 May 5;66(6):1833–1844. doi: 10.1086/302932. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Doherty C. J., MacIntyre C. Palmoplantar pustulosis and smoking. Br Med J (Clin Res Ed) 1985 Sep 28;291(6499):861–864. doi: 10.1136/bmj.291.6499.861. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pallis A. G., Mouzas I. A., Vlachonikolis I. G. The inflammatory bowel disease questionnaire: a review of its national validation studies. Inflamm Bowel Dis. 2004 May;10(3):261–269. doi: 10.1097/00054725-200405000-00014. [DOI] [PubMed] [Google Scholar]
- Paulus H. E., Bulpitt K. J., Ramos B., Park G., Wong W. K., Western Consortium of Practicing Rheumatologists Relative contributions of the components of the American College of Rheumatology 20% criteria for improvement to responder status in patients with early seropositive rheumatoid arthritis. Arthritis Rheum. 2000 Dec;43(12):2743–2750. doi: 10.1002/1529-0131(200012)43:12<2743::AID-ANR14>3.0.CO;2-A. [DOI] [PubMed] [Google Scholar]
- Richards H. L., Fortune D. G., Griffiths C. E., Main C. J. The contribution of perceptions of stigmatisation to disability in patients with psoriasis. J Psychosom Res. 2001 Jan;50(1):11–15. doi: 10.1016/s0022-3999(00)00210-5. [DOI] [PubMed] [Google Scholar]
- Sampogna Francesca, Sera Francesco, Abeni Damiano, IDI Multipurpose Psoriasis Research on Vital Experiences (IMPROVE) Investigators Measures of clinical severity, quality of life, and psychological distress in patients with psoriasis: a cluster analysis. J Invest Dermatol. 2004 Mar;122(3):602–607. doi: 10.1046/j.0022-202X.2003.09101.x. [DOI] [PubMed] [Google Scholar]
- Savin J. A. Patients' beliefs about psoriasis. Trans St Johns Hosp Dermatol Soc. 1970;56(2):139–142. [PubMed] [Google Scholar]
- Seville R. H. Psoriasis and stress. Br J Dermatol. 1977 Sep;97(3):297–302. doi: 10.1111/j.1365-2133.1977.tb15186.x. [DOI] [PubMed] [Google Scholar]
- Smith A. E., Kassab J. Y., Rowland Payne C. M., Beer W. E. Bimodality in age of onset of psoriasis, in both patients and their relatives. Dermatology. 1993;186(3):181–186. doi: 10.1159/000247341. [DOI] [PubMed] [Google Scholar]
- Tomfohrde J., Silverman A., Barnes R., Fernandez-Vina M. A., Young M., Lory D., Morris L., Wuepper K. D., Stastny P., Menter A. Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science. 1994 May 20;264(5162):1141–1145. doi: 10.1126/science.8178173. [DOI] [PubMed] [Google Scholar]
- Touw C. R., Hakkaart-Van Roijen L., Verboom P., Paul C., Rutten F. F., Finlay A. Y. Quality of life and clinical outcome in psoriasis patients using intermittent cyclosporin. Br J Dermatol. 2001 May;144(5):967–972. doi: 10.1046/j.1365-2133.2001.04183.x. [DOI] [PubMed] [Google Scholar]
- Trembath R. C., Clough R. L., Rosbotham J. L., Jones A. B., Camp R. D., Frodsham A., Browne J., Barber R., Terwilliger J., Lathrop G. M. Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis. Hum Mol Genet. 1997 May;6(5):813–820. doi: 10.1093/hmg/6.5.813. [DOI] [PubMed] [Google Scholar]
- Veal C. D., Clough R. L., Barber R. C., Mason S., Tillman D., Ferry B., Jones A. B., Ameen M., Balendran N., Powis S. H. Identification of a novel psoriasis susceptibility locus at 1p and evidence of epistasis between PSORS1 and candidate loci. J Med Genet. 2001 Jan;38(1):7–13. doi: 10.1136/jmg.38.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- de Korte John, Sprangers Mirjam A., Mombers Femke M., Bos Jan D. Quality of life in patients with psoriasis: a systematic literature review. J Investig Dermatol Symp Proc. 2004 Mar;9(2):140–147. doi: 10.1046/j.1087-0024.2003.09110.x. [DOI] [PubMed] [Google Scholar]