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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 2005 Mar;64(Suppl 2):ii58–ii60. doi: 10.1136/ard.2004.034264

Imaging the joint and enthesis: insights into pathogenesis of psoriatic arthritis

D McGonagle
PMCID: PMC1766889  PMID: 15708939

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Figure 1.

Figure 1

 Magnetic resonance imaging (MRI) of the sacroiliac joint (A) and sternoclavicular joint (B) in patients with PsA. The bone adjacent to these fibrocartilaginous joints is subject to both shear and compressive forces with the MRI changes in the bone at these sites being virtually identical to that seen in bone adjacent to the fibrocartilages of large entheses such as Achilles' tendon and plantar fascia. (A) Coronal fat suppressed MRI scan of the sacroiliac joint of a male with psoriasis, peripheral arthritis, inflammatory back pain and negative human leucocyte antigen (HLA)-B27. Osteitis is denoted by asterisks. (B) Fat suppressed coronal MRI scan of the sternoclavicular joint in a male patient with psoriatic arthritis and the SAPHO syndrome. Bone oedema is adjacent to the joint fibrocartilage (asterisk) and joint swelling (arrow). These are examples of sites with high shear and compressive stress. It is suggested that these synovial joints behave like functional entheses in having a similar MRI pattern of disease as a typical insertion and hence the extensive bone disease that is independent of synovitis. (Images courtesy of Dr L Sutton, Calderdale Royal Hospital, Halifax, UK.)

Figure 2.

Figure 2

 Fat suppressed MRI of the metacarpophalangeal (MCP) joint in a patient with psoriatic arthritis shows extracapsular inflammation (asterisk), bone oedema at the distal capsular enthesis (arrow), and bone oedema in the MCP head region where bone oedema and erosions may also occur in rheumatoid arthritis (arrowhead).

Figure 3.

Figure 3

 Radiograph of the feet of a patient with symmetrical polyarthritis with ulnar deviation of the hands and fibular deviation of the feet. The radiograph reveals joint fusion at multiple sites (arrows on top) and the fifth left metatarsal phalangeal head and adjacent proximal phalanx demonstrate pencil in cup deformity (arrow on left), features which help distinguish this as psoriatic arthritis rather than rheumatoid arthritis (RA). This case illustrates how imaging has the potential to clarify that the diagnosis is what clinically masquerades as RA.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balint P. V., Kane D., Wilson H., McInnes I. B., Sturrock R. D. Ultrasonography of entheseal insertions in the lower limb in spondyloarthropathy. Ann Rheum Dis. 2002 Oct;61(10):905–910. doi: 10.1136/ard.61.10.905. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Benjamin M., McGonagle D. The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites. J Anat. 2001 Nov;199(Pt 5):503–526. doi: 10.1046/j.1469-7580.2001.19950503.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Benjamin M., Moriggl B., Brenner E., Emery P., McGonagle D., Redman S. The "enthesis organ" concept: why enthesopathies may not present as focal insertional disorders. Arthritis Rheum. 2004 Oct;50(10):3306–3313. doi: 10.1002/art.20566. [DOI] [PubMed] [Google Scholar]
  4. D'Agostino Maria-Antonietta, Said-Nahal Roula, Hacquard-Bouder Cécile, Brasseur Jean-Louis, Dougados Maxime, Breban Maxime. Assessment of peripheral enthesitis in the spondylarthropathies by ultrasonography combined with power Doppler: a cross-sectional study. Arthritis Rheum. 2003 Feb;48(2):523–533. doi: 10.1002/art.10812. [DOI] [PubMed] [Google Scholar]
  5. Frediani B., Falsetti P., Storri L., Allegri A., Bisogno S., Baldi F., Marcolongo R. Quadricepital tendon enthesitis in psoriatic arthritis and rheumatoid arthritis: ultrasound examinations and clinical correlations. J Rheumatol. 2001 Nov;28(11):2566–2568. [PubMed] [Google Scholar]
  6. Helliwell P., Marchesoni A., Peters M., Barker M., Wright V. A re-evaluation of the osteoarticular manifestations of psoriasis. Br J Rheumatol. 1991 Oct;30(5):339–345. doi: 10.1093/rheumatology/30.5.339. [DOI] [PubMed] [Google Scholar]
  7. Jevtic V., Watt I., Rozman B., Kos-Golja M., Demsar F., Jarh O. Distinctive radiological features of small hand joints in rheumatoid arthritis and seronegative spondyloarthritis demonstrated by contrast-enhanced (Gd-DTPA) magnetic resonance imaging. Skeletal Radiol. 1995 Jul;24(5):351–355. doi: 10.1007/BF00197064. [DOI] [PubMed] [Google Scholar]
  8. Lehtinen A., Taavitsainen M., Leirisalo-Repo M. Sonographic analysis of enthesopathy in the lower extremities of patients with spondylarthropathy. Clin Exp Rheumatol. 1994 Mar-Apr;12(2):143–148. [PubMed] [Google Scholar]
  9. McGonagle D., Conaghan P. G., Emery P. Psoriatic arthritis: a unified concept twenty years on. Arthritis Rheum. 1999 Jun;42(6):1080–1086. doi: 10.1002/1529-0131(199906)42:6<1080::AID-ANR2>3.0.CO;2-7. [DOI] [PubMed] [Google Scholar]
  10. McGonagle D., Gibbon W., Emery P. Classification of inflammatory arthritis by enthesitis. Lancet. 1998 Oct 3;352(9134):1137–1140. doi: 10.1016/S0140-6736(97)12004-9. [DOI] [PubMed] [Google Scholar]
  11. McGonagle D., Gibbon W., Emery P. Classification of inflammatory arthritis by enthesitis. Lancet. 1998 Oct 3;352(9134):1137–1140. doi: 10.1016/S0140-6736(97)12004-9. [DOI] [PubMed] [Google Scholar]
  12. McGonagle D., Gibbon W., O'Connor P., Green M., Pease C., Emery P. Characteristic magnetic resonance imaging entheseal changes of knee synovitis in spondylarthropathy. Arthritis Rheum. 1998 Apr;41(4):694–700. doi: 10.1002/1529-0131(199804)41:4<694::AID-ART17>3.0.CO;2-#. [DOI] [PubMed] [Google Scholar]
  13. McGonagle D., Marzo-Ortega H., O'Connor P., Gibbon W., Hawkey P., Henshaw K., Emery P. Histological assessment of the early enthesitis lesion in spondyloarthropathy. Ann Rheum Dis. 2002 Jun;61(6):534–537. doi: 10.1136/ard.61.6.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. McGonagle D., Stockwin L., Isaacs J., Emery P. An enthesitis based model for the pathogenesis of spondyloarthropathy. additive effects of microbial adjuvant and biomechanical factors at disease sites. J Rheumatol. 2001 Oct;28(10):2155–2159. [PubMed] [Google Scholar]
  15. McGonagle Dennis, Marzo-Ortega Helena, Benjamin Michael, Emery Paul. Report on the Second international Enthesitis Workshop. Arthritis Rheum. 2003 Apr;48(4):896–905. doi: 10.1002/art.10841. [DOI] [PubMed] [Google Scholar]
  16. McGonagle Dennis, Marzo-Ortega Helena, O'Connor Philip, Gibbon Wayne, Pease Colin, Reece Richard, Emery Paul. The role of biomechanical factors and HLA-B27 in magnetic resonance imaging-determined bone changes in plantar fascia enthesopathy. Arthritis Rheum. 2002 Feb;46(2):489–493. doi: 10.1002/art.10125. [DOI] [PubMed] [Google Scholar]
  17. Mease Philip J. Recent advances in the management of psoriatic arthritis. Curr Opin Rheumatol. 2004 Jul;16(4):366–370. doi: 10.1097/01.bor.0000129720.21563.b8. [DOI] [PubMed] [Google Scholar]
  18. Namey T. C., Rosenthall L. Periarticular uptake of 99mtechnetium diphosphonate in psoriatics: correlation with cutaneous activity. Arthritis Rheum. 1976 May-Jun;19(3):607–612. doi: 10.1002/art.1780190313. [DOI] [PubMed] [Google Scholar]
  19. Punzi L., Pianon M., Bertazzolo N., Fagiolo U., Rizzi E., Rossini P., Todesco S. Clinical, laboratory and immunogenetic aspects of post-traumatic psoriatic arthritis: a study of 25 patients. Clin Exp Rheumatol. 1998 May-Jun;16(3):277–281. [PubMed] [Google Scholar]
  20. Savnik A., Malmskov H., Thomsen H. S., Graff L. B., Nielsen H., Danneskiold-Samsøe B., Boesen J., Bliddal H. Magnetic resonance imaging of the wrist and finger joints in patients with inflammatory joint diseases. J Rheumatol. 2001 Oct;28(10):2193–2200. [PubMed] [Google Scholar]
  21. Scarpa R., Del Puente A., di Girolamo C., della Valle G., Lubrano E., Oriente P. Interplay between environmental factors, articular involvement, and HLA-B27 in patients with psoriatic arthritis. Ann Rheum Dis. 1992 Jan;51(1):78–79. doi: 10.1136/ard.51.1.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Wright V. Seronegative polyarthritis: a unified concept. Arthritis Rheum. 1978 Jul-Aug;21(6):619–633. doi: 10.1002/art.1780210603. [DOI] [PubMed] [Google Scholar]

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