Figure 4.

Kaplan-Meier (product limit) curves for the survival of patients with β MHC mutations in the study population. There was a significant difference in survival between subjects classified according to the affected functional domain and the charge change of the encoded amino acid (p=0.02, log rank test). Survival was significantly shortened in subjects with actin binding (+) or rod (+) defects. (0) indicates conservative amino acid substitution, (+) indicates non-conservative amino acid substitution. (1) Actin binding (0) defects: (— — —); (2) actin binding (+) defects: (▴—▴); (3) active site (0) defects: (); (4) active site (+) defects: (- - - - -); (5) rod (0) defects: (x..........x); and (6) rod (+) defects (• - - - - - •).