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. 1995 Jul;177(14):4053–4058. doi: 10.1128/jb.177.14.4053-4058.1995

Guanosine 3',5'-bispyrophosphate (ppGpp) synthesis in cells of Escherichia coli starved for Pi.

B Spira 1, N Silberstein 1, E Yagil 1
PMCID: PMC177136  PMID: 7608079

Abstract

Cells of Escherichia coli which enter a phase of starvation for Pi induce the synthesis of the nucleotide guanosine 3',5'-bispyrophosphate (ppGpp). This induction is relA independent but depends on the spoT gene product. A mutant unable to produce ppGpp is impaired in the expression of two genes which belong to the pho regulon, a defect which is dependent on the product of spoT. We suggest that ppGpp is essential for the proper induction of the genes which belong to the pho regulon.

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Selected References

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