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. 1995 Sep;177(18):5355–5357. doi: 10.1128/jb.177.18.5355-5357.1995

Genetic analysis suggests functional interactions between the N- and C-terminal domains of the TetA(C) efflux pump encoded by pBR322.

P McNicholas 1, M McGlynn 1, G G Guay 1, D M Rothstein 1
PMCID: PMC177333  PMID: 7665527

Abstract

Genetic analysis of the tetA(C) gene of pBR322 indicates the importance of two-cytoplasmic loops in the TetA(C) protein (P. McNicholas, I. Chopra, and D. M. Rothstein, J. Bacteriol. 174:7926-7933, 1992). In this study, we characterized second-site suppressor mutations that suggest a functional interaction between these two cytoplasmic regions of the protein.

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Selected References

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