Table 2.
Methylation (%) | ||||||
Feature (n) | p16 | MDR1 | MINT-2 | One | Two | Three |
Total (275) | 100 (36) | 67 (24) | 102 (37) | 141 (51) | 88 (32) | 40 (15) |
TP53 | ||||||
Wild-type (152) | 59 (39) | 40 (26) | 62 (41) | 79 (52) | 54 (36) | 28 (18) |
Mutant (103) | 30 (29)* | 18 (18)† | 26 (25)‡ | 46 (44) | 21 (20)‡ | 7 (7)‡ |
K-ras | ||||||
Wild-type (138) | 51 (37) | 41 (30) | 50 (36) | 67 (46) | 49 (36) | 26 (19) |
Mutant (65) | 17 (26)* | 7 (11)§ | 18 (28) | 28 (44) | 11 (17)‡ | 3 (5)‡ |
MSI | ||||||
− (228) | 70 (31) | 40 (18) | 70 (31) | 106 (45) | 58 (25) | 16 (7) |
+ (41) | 28 (68)§ | 27 (66)§ | 30 (73)§ | 32 (77)§ | 29 (71)§ | 24 (59)§ |
*p<0.2; †p<0.1; ‡p<0.05; §p<0.005.
MSI, microsatelite instability.