Figure 3 .

Effects of protein kinase C (PKC) isozyme mutants on gastrin induced nuclear factor κB (NFκB) activation. MKGR26 cells were cotransfected with 0.5 μg of pNFκB-LUC and a construct encoding the dominant negative (dn) mutant of PKC-δ or PKC-θ. After 24 hours, cells were treated with gastrin for eight hours and the luciferase assay was performed. The results are expressed as fold induction compared with control cells treated with vehicle alone. Values are means (SEM) from six independent experiments (*p<0.05 v bar 1; †p<0.05 v bar 2).