Table 2.

Non-parametric (median) univariate and multivariate regression analyses of demographic and virological factors associated with FPR in both HCV monoinfected and HIV-HCV coinfected patients combined

Factor	Univariate, coefficient (95% CI)	p Value	Multivariable, coefficient (95% CI)	p Value
Age at HCV infection (y)	0.0038 (0.002–0.0054)	<0.0001	0.0044 (0.0029–0.0059)	<0.0001
Sex (male v female)	0.0095 (0.0043–0.023)	0.575	—	—
Source of HCV (IDU v transfusion)	0.020 (0.0236–0.0646)	0.360	—	—
HIV positive	0.0489 (0.006–0.091)	0.005	0.0344 (0.0056–0.0633)	0.019
Alcohol consumption	0.0008 (−0.0008–0.001)	0.616	—	—
ALT level at liver biopsy	0.0002 (0.00004–0.0004)	0.014	0.0001 (0.00003–0.00035)	0.039
HCV genotype (1 v others)	0.0000 (−0.0309–0.0309)	1	—	—
Inflammatory grade	0.023 (0.013–0.033)	<0.0001	0.0224 (0.0149–0.0300)	<0.0001

HIV, human immunodeficiency virus; HCV, hepatitis C virus; IDU, injecting drug use; ALT, alanine aminotransferase; FPR, fibrosis progression rate.

Duration of HCV infection was excluded from this analysis as it was used to derive FPR and is therefore highly correlated with fibrosis progression rate.