Figure 2.

 Macroscopic (A) and microscopic (B, C) appearance of gastric cancers in wild-type mice. (A) Multiple polypoid tumours are evident in the stomachs of inducible nitric oxide synthase (iNOS) wild-type mice after N-methyl-N-nitrosourea and Helicobacter pylori treatment. (B) The polypoid mass shows an intramucosal adenocarcinoma with disseminated neoplastic glandular formations (original magnification ×100). (C) The adenocarcinoma shows an atypical irregular glandular hyperplasia with cribriform appearance, which is composed of pleomorphic atypical tumour cells with oval to round nuclei, with many mitotic figures apparent (arrow) (original magnification ×400).