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Cumulative survival rate according to changes in the v signal score after two cycles of treatment. Median survival time (MST) of patients in the non-increased v signal group (n = 22) was 382 days (range 71–484) and for those in the increased group (n = 9), 176 days (range 68–257). MST in the increased group was significantly shorter compared with the non-increased group (log rank test; p = 0.0094).
