Figure 3.

 Transfer of CD4⁺CD62L⁺ cells from toll-like receptor 9 (TLR9) deficient mice versus wild-type mice. CD4⁺CD62L⁺ cells from TLR9 deficient donors or wild-type control littermates were isolated and transferred to SCID recipients. (A) Weight change after transfer. (B) Histological score of the different groups was examined at the end of the experiment (seven weeks after transfer). (C) Mesenteric lymph node cells were isolated at the end of the experiment and cytokine secretion was measured after 24 hours in supernatants by ELISA. IL, interleukin; IFN-γ, interferon γ. *Significantly different from the group transferred with CD4⁺CD62L⁺ cells from wild-type littermates. Data presented were derived from five mice per group and are representative of two independent experiments.