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. 1995 Nov;177(22):6688–6692. doi: 10.1128/jb.177.22.6688-6692.1995

Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis.

S L Otten 1, X Liu 1, J Ferguson 1, C R Hutchinson 1
PMCID: PMC177529  PMID: 7592454

Abstract

The dnrQS genes from the daunorubicin producer Streptomyces peucetius were characterized by DNA sequencing, complementation analysis, and gene disruption. The dnrQ gene is required for daunosamine biosynthesis, and dnrS appears to encode a glycosyltransferase for the addition of the 2,3,6-trideoxy-3-aminohexose, daunosamine, to epsilon-rhodomycinone.

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Selected References

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