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. 1973 Apr;47(4):700–706. doi: 10.1111/j.1476-5381.1973.tb08196.x

Mechanism of histamine-induced antidiuretic response

K P Bhargava, V K Kulshrestha, G Santhakumari, Y P Srivastava
PMCID: PMC1776063  PMID: 4723794

Abstract

1. In dogs anaesthetized with α-chloralose, intracerebroventricular (i.c.v.) injection of histamine induced antidiuresis and increase in jugular vein blood antidiuretic hormone (ADH) level but no change in urinary electrolytes. The mechanism of the histamine-induced antidiuretic response was analysed by the use of pharmacological agents.

2. Histamine (i.c.v.) in 1-20 μg doses produced a variable effect on urine outflow as well as on the blood ADH concentration; however, higher doses (25-500 μg) of histamine elicited a dose-dependent antidiuretic response with concomitant rise in blood ADH titre.

3. Repeated administration of high doses of i.c.v. histamine (400 μg) elicited a diminishing antidiuretic response which was not observable after the fourth dose, thus exhibiting tachyphylaxis. The antidiuretic response to histamine could be restored by central administration of noradrenaline (500 μg).

4. Central pretreatment with mepyramine (5 mg) prevented the histamine-induced antidiuresis. Atropine (2 mg i.c.v.) was ineffective in blocking the antidiuretic effect of histamine. A diuretic response to histamine (400 μg i.c.v.) was obtained in phenoxybenzamine (i.c.v.) pretreated animals; this response could be blocked by i.c.v. injection of propranolol. Tetrabenazine pretreatment prevented the antidiuretic response to histamine.

5. The results of the study lead us to conclude that histamine releases central catecholamines which activate the central adrenergic mechanism for the release of antidiuretic hormone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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