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. 1973 May;48(1):139–143. doi: 10.1111/j.1476-5381.1973.tb08231.x

Effect of cocaine on the affinity of α-adrenoceptors for noradrenaline

I R Innes, R Mailhot
PMCID: PMC1776107  PMID: 4724185

Abstract

1. Doses of cocaine which cause specific or unspecific supersensitivity in cat spleen did not alter the blocking effect of phenoxybenzamine on the responses of isolated cat spleen strips to noradrenaline.

2. The same doses of cocaine did not increase the protection of α-adrenoceptors given by noradrenaline during a standard exposure to phenoxybenzamine.

3. It is concluded that cocaine does not change the affinity of the α-adrenoceptor for noradrenaline, and therefore changes in affinity are not responsible for the potentiating action of cocaine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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