Abstract
Monoamine oxidase and aldehyde dehydrogenase activity were significantly reduced in the striatum of rats 8 days after lesion of the nigrostriatal nerve pathway caused by 6-hydroxydopamine. Evidence is presented for the existence of an intraneuronal 'dopamine monoamine oxidase' and intraneuronal aldehyde dehydrogenase. Dopamine concentrations were reduced to 10% of their control values.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Almgren O., Andén N. E., Jonason J., Norberg K. A., Olson L. Cellular localization of monoamine oxidase in rat salivary glands. Acta Physiol Scand. 1966 May;67(1):21–26. doi: 10.1111/j.1748-1716.1966.tb03282.x. [DOI] [PubMed] [Google Scholar]
- Collins G. G., Sandler M., Williams E. D., Youdim M. B. Multiple forms of human brain mitochondrial monoamine oxidase. Nature. 1970 Feb 28;225(5235):817–820. doi: 10.1038/225817a0. [DOI] [PubMed] [Google Scholar]
- Deitrich R. A. Tissue and subcellular distribution of mammalian aldehyde-oxydizing capacity. Biochem Pharmacol. 1966 Dec;15(12):1911–1922. doi: 10.1016/0006-2952(66)90220-6. [DOI] [PubMed] [Google Scholar]
- Duncan R. J., Sourkes T. L., Boucher R., Poirier L. J., Roberge A. Aldehyde dehydrogenase and monoamine oxidase in the striatum of cats with nigrostriatal lesions. J Neurochem. 1972 Aug;19(8):2007–2010. doi: 10.1111/j.1471-4159.1972.tb01490.x. [DOI] [PubMed] [Google Scholar]
- Goldstein M., Anagnoste B., Battista A. F., Owen W. S., Nakatani S. Studies of amines in the striatum in monkeys with nigral lesions. The disposition, biosynthesis and metabolites of [3H]dopamine and [14C]serotonin in the striatum. J Neurochem. 1969 Apr;16(4):645–653. doi: 10.1111/j.1471-4159.1969.tb06864.x. [DOI] [PubMed] [Google Scholar]
- Jarrott B., Iversen L. L. Noradrenaline metabolizing enzymes in normal and sympathetically denervated vas deferens. J Neurochem. 1971 Jan;18(1):1–6. doi: 10.1111/j.1471-4159.1971.tb00161.x. [DOI] [PubMed] [Google Scholar]
- Jarrott B. Occurrence and properties of monoamine oxidase in adrenergic neurons. J Neurochem. 1971 Jan;18(1):7–16. doi: 10.1111/j.1471-4159.1971.tb00162.x. [DOI] [PubMed] [Google Scholar]
- Javoy F., Hamon M., Glowinski J. Disposition of newly synthesized amines in cell bodies and terminals of central catechol aminergic neurons. I. Effect of amphetamine and thiorproperazine on the metabolism of CA in the caudate nucleus, the substantia nigra and the ventromedial nucleus of the hypothalamus. Eur J Pharmacol. 1970 May;10(2):178–188. doi: 10.1016/0014-2999(70)90271-2. [DOI] [PubMed] [Google Scholar]
- Krajl M. A rapid microfluorimetric determination of monoamine oxidase. Biochem Pharmacol. 1965 Nov;14(11):1684–1686. doi: 10.1016/0006-2952(65)90025-0. [DOI] [PubMed] [Google Scholar]
- Kroon M. C., Veldstra H. Multiple forms of rat brain mitochondrial monoamine oxidase. Subcellular localization. FEBS Lett. 1972 Aug 1;24(2):173–176. doi: 10.1016/0014-5793(72)80760-9. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Robinson D. S., Lovenberg W., Keiser H., Sjoerdsma A. Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and in vivo. Biochem Pharmacol. 1968 Jan;17(1):109–119. doi: 10.1016/0006-2952(68)90163-9. [DOI] [PubMed] [Google Scholar]
- Sandler M., Youdim M. B. Multiple forms of monoamine oxidase: functional significance. Pharmacol Rev. 1972 Jun;24(2):331–348. [PubMed] [Google Scholar]
- Thoenen H., Tranzer J. P. Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968;261(3):271–288. doi: 10.1007/BF00536990. [DOI] [PubMed] [Google Scholar]
- Tipton K. F., Youdim M. B., Spires I. P. Beef adrenal medulla monoamine oxidase. Biochem Pharmacol. 1972 Aug 15;21(16):2197–2204. doi: 10.1016/0006-2952(72)90035-4. [DOI] [PubMed] [Google Scholar]
- Ungerstedt U. 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. Eur J Pharmacol. 1968 Dec;5(1):107–110. doi: 10.1016/0014-2999(68)90164-7. [DOI] [PubMed] [Google Scholar]
- Uretsky N. J., Iversen L. L. Effects of 6-hydroxydopamine on noradrenaline-containing neurones in the rat brain. Nature. 1969 Feb 8;221(5180):557–559. doi: 10.1038/221557a0. [DOI] [PubMed] [Google Scholar]