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. 1973 Aug;48(4):667–675. doi: 10.1111/j.1476-5381.1973.tb08255.x

Effects of cocaine or denervation on responses of isolated strips of cat spleen to (—)-noradrenaline and (—)-isoprenaline

A R Granata, S Z Langer
PMCID: PMC1776144  PMID: 4788210

Abstract

1. A study has been made of the effects of cocaine and sympathetic denervation on responses of the cat spleen to (—)-noradrenaline and (—)-isoprenaline.

2. Responses of isolated strips of spleen capsule to (—)-noradrenaline or to (—)-isoprenaline were not affected by reserpine-pretreatment.

3. In adult cats, cocaine (1 and 10 μg/ml) or denervation produced a shift to the left of dose-response curves to (—)-noradrenaline, whereas they failed to modify dose-response curves to (—)-isoprenaline.

4. There was an increase in the maximum development of tension to (—)-noradrenaline after denervation or in the presence of cocaine (10 μg/ml). These procedures did not increase the maximal responses to (—)-isoprenaline.

5. Cocaine (10 μg/ml) did not affect dose-response curves to (—)-noradrenaline or (—)-isoprenaline in the denervated spleen.

6. In the kitten spleen, cocaine (1 and 10 μg/ml) produced a shift to the left of dose-response curves to (—)-noradrenaline both in untreated and in reserpine-pretreated tissues.

7. There was a small shift to the left in dose-response curves to (—)-isoprenaline in the presence of cocaine in the untreated but not in the reserpine-pretreated kitten spleen.

8. It is concluded that the potentiation of responses to (—)-noradrenaline in the cat's spleen is due to a prejunctional effect of cocaine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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