Abstract
1. Anaphylaxis was induced in the isolated heart of the guinea-pig in the presence of burimamide at concentrations of 4 × 10-5M and 2·7 × 10-4M.
2. Burimamide did not affect the immunological release of histamine; however, it selectively antagonized the positive inotropic and chronotropic effects of released histamine. The antagonism of the positive chronotropic effect was concentration-dependent.
3. Neither the negative dromotropic effect nor the decrease in coronary flow rate occurring during anaphylaxis were inhibited by burimamide.
4. The results are in agreement with the double histamine receptor theory and suggest that, in the heart of the guinea-pig, H2-receptors are involved in the positive inotropic and chronotropic effects of released histamine, and H1-receptors in the negative dromotropic effect.
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Selected References
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- Anton A. H., Sayre D. F. A modified fluorometric procedure for tissue histamine and its distribution in various animals. J Pharmacol Exp Ther. 1969 Apr;166(2):285–290. [PubMed] [Google Scholar]
- Ash A. S., Schild H. O. Receptors mediating some actions of histamine. Br J Pharmacol Chemother. 1966 Aug;27(2):427–439. doi: 10.1111/j.1476-5381.1966.tb01674.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BARTLET A. L. THE ACTION OF HISTAMINE ON THE ISOLATED HEART. Br J Pharmacol Chemother. 1963 Dec;21:450–461. doi: 10.1111/j.1476-5381.1963.tb02013.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BEANI L. Un semplice apparecchio per perfusione. Boll Soc Ital Biol Sper. 1953 Jul;29(7):1398–1401. [PubMed] [Google Scholar]
- Black J. W., Duncan W. A., Durant C. J., Ganellin C. R., Parsons E. M. Definition and antagonism of histamine H 2 -receptors. Nature. 1972 Apr 21;236(5347):385–390. doi: 10.1038/236385a0. [DOI] [PubMed] [Google Scholar]
- FEIGEN G. A., VAUGHAN WILLIAMS E. M., PETERSON J. K., NIELSEN C. B. Histamine release and intracellular potentials during anaphylaxis in the isolated heart. Circ Res. 1960 Jul;8:713–723. doi: 10.1161/01.res.8.4.713. [DOI] [PubMed] [Google Scholar]
- Feigen G. A., Prager D. J. Experimental cardiac anaphylaxis. Physiologic, pharmacologic and biochemical aspects of immune reactions in the isolated heart. Am J Cardiol. 1969 Oct;24(4):474–491. doi: 10.1016/0002-9149(69)90490-1. [DOI] [PubMed] [Google Scholar]
- Flacke W., Atanacković D., Gillis R. A., Alper M. H. The actions of histamine on the mammalian heart. J Pharmacol Exp Ther. 1967 Feb;155(2):271–278. [PubMed] [Google Scholar]
- Hahn F., Bernauer W. Studies on heart anaphylaxis. 3. Effect of antigen and histamine on perfused guinea-pig heart. Arch Int Pharmacodyn Ther. 1970 Mar;184(1):129–157. [PubMed] [Google Scholar]
- Levi R. Effects of exogenous and immunologically released histamine on the isolated heart: a quantitative comparison. J Pharmacol Exp Ther. 1972 Aug;182(2):227–238. [PubMed] [Google Scholar]
- Levi R. Hypersensitivity reactions of the heart: reduction of anaphylactic crisis by theophylline or glucagon. Bull N Y Acad Med. 1971 Oct;47(10):1229–1229. [PMC free article] [PubMed] [Google Scholar]
- PENNA M., ILLANES A., UBILLA M., MUJICA S. Effect of histamine and of the anaphylactic reaction on isolated guinea pig atria. Circ Res. 1959 Jul;7(4):521–526. doi: 10.1161/01.res.7.4.521. [DOI] [PubMed] [Google Scholar]
- TRENDELENBURG U. The action of histamine and 5-hydroxytryptamine on isolated mammalian atria. J Pharmacol Exp Ther. 1960 Dec;130:450–460. [PubMed] [Google Scholar]