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. 1973 Aug;48(4):570–576. doi: 10.1111/j.1476-5381.1973.tb08243.x

Role of 5-hydroxytryptamine in ketamine-induced hypothermia in the rat

I Fahim, M Ismail, O H Osman
PMCID: PMC1776151  PMID: 4274691

Abstract

1. Intraperitoneal injection of graded doses of ketamine produced a dose-dependent fall in body temperature of rats. Similarly, intracerebral injection of much smaller doses produced hypothermia.

2. Pretreatment of the rats with p-chlorophenylalanine (PCPA) greatly attenuated the hypothermic response to ketamine whereas the intraperitoneal injection of 5-hydroxytryptophan in PCPA-treated rats restored the hypothermic effect of ketamine.

3. Depletion of the brain monoamines by reserpine completely prevented the ketamine-induced hypothermia. Treatment with sodium diethyldithiocarbamate (DEDTC), however, did not modify the hypothermic effect of ketamine.

4. Pretreatment of the rats with pargyline potentiated the ketamine-induced hypothermia.

5. Depletion of brain monoamines by reserpine in combination with inhibition of noradrenaline biosynthesis (DEDTC) resulted in a long lasting fall in temperature which was not modified by ketamine.

6. When the ambient temperature was raised from 26° C to 32° C, ketamine-induced hypothermia was much reduced and superimposed on a hyperthermia which occurred in all animals.

7. It is concluded that ketamine produces hypothermia in rats possibly through the release of 5-hydroxytryptamine in the hypothalamus and that this effect is similar in some respects to that produced by morphine in non-tolerant rats.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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