Abstract
1. Results obtained with a dog donor-recipient model indicate that following intravenous administration of nitrofurantoin sodium, nitrofurantoin is subjected to enterohepatic cycling. At least one-third of the nitrofurantoin originally excreted in the donors' bile after a nitrofurantoin dose of 3 mg/kg is reabsorbed intestinally in the recipients within 3 hours.
2. After intraduodenal administration of a nitrofurantoin suspension to dogs at doses ranging from 2 to 12 mg/kg, about 10% of the dose is recovered in bile as nitrofurantoin within 6 hours. A hydrocholeretic effect was also observed which correlated with the amount of drug administered. Both biliary drug excretion and the related hydrocholeresis appeared linearly related over the drug dose range.
3. The hydrocholeresis observed in dogs within 3 h after intravenously administered nitrofurantoin sodium, equivalent to 3 mg/kg nitrofurantoin, was at least ten times that seen following the intravenous administration of an equimolar dose of dehydrocholic acid given as its sodium salt.
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Selected References
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- COOK D. L., BIANCHI R. G., HAMBOURGER W. E., GREEN D. M. Studies on five long-acting choleretics. J Pharmacol Exp Ther. 1950 Dec;100(41):421–428. [PubMed] [Google Scholar]
- Conklin J. D., Hollifield R. D. A new method for the determination of nitrofurantoin in urine. Clin Chem. 1965 Oct;11(10):925–931. [PubMed] [Google Scholar]
- Conklin J. D., Hollifield R. D. A quantitative procedure for the determination of nitrofurantoin in whole blood and plasma. Clin Chem. 1966 Oct;12(10):690–696. [PubMed] [Google Scholar]
- Conklin J. D., Wagner D. L. Excretion of nitrofurantoin in dog hepatic bile. Br J Pharmacol. 1971 Sep;43(1):140–150. doi: 10.1111/j.1476-5381.1971.tb07163.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STEWART G. T., HARRISON P. M. Excretion and re-excretion of a broad-spectrum penicillin in bile. Br J Pharmacol Chemother. 1961 Dec;17:414–419. doi: 10.1111/j.1476-5381.1961.tb01127.x. [DOI] [PMC free article] [PubMed] [Google Scholar]