Abstract
1. In conscious rabbits, the rapid intravenous injection of levodopa alone does not have any significant effects on the blood pressure in doses up to 10 mg/kg.
2. After inhibition of monoamine oxidase, levodopa induces a sustained pressor response.
3. This response can be blocked by inhibition of extracerebral decarboxylase.
4. Possible mechanisms for these interactions are discussed, together with their therapeutic implications in Parkinsonism.
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Selected References
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- Goldberg L. I. Cardiovascular and renal actions of dopamine: potential clinical applications. Pharmacol Rev. 1972 Mar;24(1):1–29. [PubMed] [Google Scholar]
- Hamilton T. C. Effects of dopamine on the conductance of perfused vascular beds of the chloralosed cat. Br J Pharmacol. 1972 Mar;44(3):442–450. doi: 10.1111/j.1476-5381.1972.tb07282.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henning M., Rubenson A. Evidence for a centrally mediated hypotensive effect of L-dopa in the rat. J Pharm Pharmacol. 1970 Mar;22(3):241–243. doi: 10.1111/j.2042-7158.1970.tb08510.x. [DOI] [PubMed] [Google Scholar]
- Osborne M. W., Wenger J. J., Willems W. The cardiovascular pharmacology of L(--)-dopa: peripheral and central effects. J Pharmacol Exp Ther. 1971 Sep;178(3):517–528. [PubMed] [Google Scholar]
- Roberts D. J., Street D. M., Farmer J. B. Influence of pargyline on the effects of dopamine infusions on sympathetically innervated tissues. Neuropharmacology. 1970 Sep;9(5):457–465. doi: 10.1016/0028-3908(70)90019-5. [DOI] [PubMed] [Google Scholar]
- Robson R. D. Modification of the cardiovascular effects of L-dopa in anesthetized dogs by inhibitors of enzymes involved in catecholamine metabolism. Circ Res. 1971 Jun;28(6):662–670. doi: 10.1161/01.res.28.6.662. [DOI] [PubMed] [Google Scholar]
- Schmitt H., Fénard S. New evidence for an -andrenergic component in the sympathetic centres: centrally mediated decrease in sympathetic tone by L-dopa and its antagonism by piperoxane and yohimbine. Eur J Pharmacol. 1972 Feb;17(2):293–296. doi: 10.1016/0014-2999(72)90173-2. [DOI] [PubMed] [Google Scholar]