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. 1973 Mar;47(3):498–503. doi: 10.1111/j.1476-5381.1973.tb08181.x

Effects of prostaglandin E1 on acid secretion, mucosal histamine content and histidine decarboxylase activity in rat stomach

R Håkanson, G Liedberg, J Oscarson
PMCID: PMC1776351  PMID: 4730828

Abstract

1. Prostaglandin E1 inhibits basal and pentagastrin-stimulated gastric acid secretion. The mechanism of this action is not clear. One possible explanation might be that prostaglandin E1 interferes with the local release or synthesis of histamine which has been proposed as the mediator of the effects of gastrin on the parietal cell.

2. A single injection of prostaglandin E1 did not affect mucosal histamine content or histidine decarboxylase activity in the rat stomach. Pentagastrin lowered the histamine content and activated the histidine decarboxylase to the same extent in prostaglandin E1-pretreated and in control rats. We conclude therefore that the inhibitory effect of prostaglandin E1 on basal and pentagastrin-stimulated acid secretion is not caused by inhibition of histamine release or histamine synthesis.

3. Repeated injections of prostaglandin E1 resulted in a significant elevation of the gastric histidine decarboxylase activity in normal but not in antrectomized rats. Conceivably, this increase in enzyme activity is secondary to prostaglandin E1-induced inhibition of acid secretion, which will stimulate release of gastrin due to the rise in intragastric pH.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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