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. 1973 Oct;49(2):243–252. doi: 10.1111/j.1476-5381.1973.tb08369.x

The effects of (-)-Δ9-tetrahydrocannabinol on reserpine-induced hypothermia in rats

L F Englert, B T Ho, Dorothy Taylor
PMCID: PMC1776374  PMID: 4793331

Abstract

1. An intravenous injection into rats of 1 mg/kg (-)-Δ9-tetrahydrocannabinol Δ9-THC) had no effect on rectal temperature and produced in the subcellular fractions of the brain a shift of 5-hydroxytryptamine (5-HT) from the particulate or `bound' 5-HT to the supernatant or `free' fraction, whereas the noradrenaline (NA) decreased in both fractions.

2. Pretreatment of rats by an intravenous injection of 1 mg/kg Δ9-THC three times a week for four weeks, prevented the hypothermia and the reduction in brain 5-HT produced by an intraperitoneal injection of 15 mg/kg reserpine given 24 h after the last Δ9-THC injection.

3. Pretreatment of rats by a single intravenous injection of 1 mg/kg Δ9-THC prevented the hypothermia and reduction in brain 5-HT produced by an intraperitoneal injection of reserpine given 1 h before. The reduction in brain NA was not prevented except at the 18 h time interval.

4. An injection of 1 mg/kg Δ9-THC intravenously into rats 3 h after an intraperitoneal injection of reserpine accentuated the reserpine hypothermia as well as the reduction of 5-HT but not of NA in the brain.

5. The reserpine hypothermia was not prevented by a single intravenous injection of 1 mg/kg Δ9-THC when cinanserin, a 5-HT inhibitor, was injected 30 min before the reserpine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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