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. 1973 Oct;49(2):373–375. doi: 10.1111/j.1476-5381.1973.tb08388.x

Brain levels of Δ1-tetrahydro-cannabinol and its metabolites in mice tolerant to the hypothermic effect of Δ1-tetrahydrocannabinol

D K Lawrence, R G Pertwee
PMCID: PMC1776396  PMID: 4793443

Abstract

Repeated voluntary consumption of cannabis in milk (approximately 8 mg per day for 15 days) produced in mice tolerance to the hypothermic effect of tritiated Δ1-tetrahydrocannabinol ([3H]-Δ1-THC; 2 mg/kg i.v.) but not to the effect of [3H]-Δ1-THC on immobility index. The development of tolerance was not accompanied by any detectable change in levels of radioactivity in the brain assigned to Δ1-THC or its metabolites. It was concluded that changes in metabolism or distribution of Δ1-THC are not responsible for tolerance at least to the hypothermic effect of Δ1-THC in mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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