Abstract
1. Three groups of obese patients were treated for periods of up to 6 months. One group of 52 individuals received 80-120 mg fenfluramine daily. The second group of 20 people had placebo tablets. The third group of 28 patients were on a dietary restricted régime.
2. Only the fenfluramine and dietary treated groups lost weight but there was no evidence of an increased metabolic rate after fenfluramine, either at rest or in standardized exercise. During the first month of treatment the mean weight loss in the group treated with fenfluramine was greater than that in the group treated by diet alone, but the difference was not significant (P<0·05). By the third month of treatment the mean weight loss was smaller in both groups, particularly in the women.
3. The composition of the tissue lost in the weight reduction had a mean fat content of 75% and did not differ significantly between the fenfluramine group and the diet-restricted group, except in women.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barnard D. L., Ford J., Garnett E. S., Mardell R. J., Whyman A. E. Changes in body composition produced by prolonged total starvation and refeeding. Metabolism. 1969 Jul;18(7):564–569. doi: 10.1016/0026-0495(69)90090-0. [DOI] [PubMed] [Google Scholar]
- Brodbin P., O'Connor C. A. A double-blind clinical trial of an appetite depressant, fenfluramine, in general practice. Practitioner. 1967 May;198(187):707–710. [PubMed] [Google Scholar]
- DURNIN J. V., NAMYSLOWSKI L. Individual variations in the energy expenditure of standardized activities. J Physiol. 1958 Oct 31;143(3):573–578. doi: 10.1113/jphysiol.1958.sp006078. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Durnin J. V., Rahaman M. M. The assessment of the amount of fat in the human body from measurements of skinfold thickness. Br J Nutr. 1967 Aug;21(3):681–689. doi: 10.1079/bjn19670070. [DOI] [PubMed] [Google Scholar]
- ENTENMAN C., GOLDWATER W. H., AYRES N. S., BEHNKE A. R., Jr Analysis of adipose tissue in relation to body weight loss in man. J Appl Physiol. 1958 Jul;13(1):129–134. doi: 10.1152/jappl.1958.13.1.129. [DOI] [PubMed] [Google Scholar]
- JOHNSTON L. C., BERSTEIN L. M. Body composition and oxygen consumption of overweight, normal, and underweight women. J Lab Clin Med. 1955 Jan;45(1):109–118. [PubMed] [Google Scholar]
- KEYS A., BROZEK J. Body fat in adult man. Physiol Rev. 1953 Jul;33(3):245–325. doi: 10.1152/physrev.1953.33.3.245. [DOI] [PubMed] [Google Scholar]
- PASSMORE R., STRONG J. A., RITCHIE F. J. The chemical composition of the tissue lost by obese patients on a reducing regimen. Br J Nutr. 1958;12(1):113–122. doi: 10.1079/bjn19580015. [DOI] [PubMed] [Google Scholar]
- Pawan G. L. Effect of fenfluramine on blood-lipids in man. Lancet. 1969 Mar 8;1(7593):498–500. doi: 10.1016/s0140-6736(69)91594-3. [DOI] [PubMed] [Google Scholar]
- Silverstone J. T., Cooper R. M., Begg R. R. A comparative trial of fenfluramine and diethylpropion inbesity. Br J Clin Pract. 1970 Oct;24(10):423–425. [PubMed] [Google Scholar]
- Traherne J. B. A clinical trial of fenfluramine. Practitioner. 1965 Nov;195(169):677–680. [PubMed] [Google Scholar]