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. 1973 Jan;47(1):85–96. doi: 10.1111/j.1476-5381.1973.tb08161.x

The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea-pig heart

S I Baskin, S Dutta, B H Marks
PMCID: PMC1776525  PMID: 4717023

Abstract

1. Diphenylhydantoin (DPH) and potassium significantly prevent ouabain intoxication without preventing the inotropic effects of ouabain in the guinea-pig isolated heart.

2. The antiarrhythmic effect of DPH and K on ouabain-induced toxicity appears to be related to their ability to reduce ouabain accumulation by the myocardium and thereby prevent the intracellular Na and K changes which lead to the arrhythmic state.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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