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. 1973 Jan;47(1):161–171. doi: 10.1111/j.1476-5381.1973.tb08170.x

Action of several β-adrenoceptor blocking drugs in the pregnant sheep and foetus

J F Truelove, G R Van Petten, R F Willes
PMCID: PMC1776527  PMID: 4146153

Abstract

1. The effect of several β-adrenoceptor blocking drugs on the pregnant ewe and foetus were studied. Bunolol, butidrine, oxprenolol, propranolol and USVP65-24 all crossed the ovine placenta and produced a β-adrenoceptor blockade in the ovine foetus. AH3474, AY21011 and sotalol did not cross the ovine placenta as assessed by the absence of a β-blockade in the foetus when these compounds were administered to the pregnant ewe.

2. Of the β-blocking compounds tested, only propranolol and oxprenolol produced a prolonged blockade in the foetus. The β-blockade with propranolol was of 3 h duration in the ewe and 10 h duration in the foetus. Oxprenolol produced a β-blockade of 3 h duration in the ewe and 8 h in the foetus.

3. The β-blocking drugs which did cross the ovine placenta were more soluble in organic solvents (ether, chloroform, corn oil and olive oil) than those which did not cross the ovine placenta.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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