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. 1974 Jan;50(1):125–129. doi: 10.1111/j.1476-5381.1974.tb09599.x

Calcium dependence of the inhibitory effect of angiotensin on renin secretion in the isolated perfused kidney of the rat

R Van Dongen, WS Peart
PMCID: PMC1776582  PMID: 4362948

Abstract

1 The effect of calcium on the inhibition of renin secretion by biologically active angiotensin was investigated in the isolated rat kidney perfused with Krebs-Ringer saline.

2 In the presence of calcium (3.7 mM), asp(NH2)′-angiotensin II suppressed both basal and isoprenaline-stimulated renin secretion. Renal perfusion pressure, which was increased by the infusion of angiotensin, returned to control levels when isoprenaline was added.

3 When the calcium concentration was reduced to 0.32 mM, the vasoconstriction produced by angiotensin was abolished although the inhibitory effect on renin secretion was still evident.

4 In the absence of calcium, angiotensin no longer suppressed basal renin secretion and a prompt increase in renin secretion occurred when isoprenaline was added.

5 The higher basal renin levels which were observed in calcium-free perfusions, suggest the existence of an intrarenal calcium-dependent mechanism that regulates basal renin secretion.

6 These observations indicate that the inhibitory effect of biologically active angiotensin, on basal and isoprenaline-stimulated renin secretion, is functionally related to the contractor response by its dependence on calcium. The recognition that the renin-producing cells are modified smooth muscle cells supports this association

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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