Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1974 Jan;50(1):57–62. doi: 10.1111/j.1476-5381.1974.tb09592.x

Modification of brain acetylcholine release by morphine and its antagonists in normal and morphine-dependent rats

K Jhamandas, M Sutak
PMCID: PMC1776585  PMID: 4856723

Abstract

1 The spontaneous release of acetylcholine (ACh) from the cerebral cortex of control and morphine-dependent rats was investigated. The rate of resting output of ACh in morphine-dependent animals was lower than that in the control animals.

2 Administration of naloxone and nalorphine to morphine-dependent rats was followed by a significant rise in the release of cortical ACh. In control rats no such increase in the release of ACh occurred after similar injections of narcotic antagonists.

3 Injections of morphine produced a consistent decrease in the rate of spontaneous release of cortical ACh in the control rats, but similar injections in the dependent rats did not produce a decrease in the rate of cortical ACh release.

4 The relevance of these results with regard to development of the narcotic abstinence syndrome is discussed.

Full text

PDF
57

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Collier H. O., Francis D. L., Schneider C. Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretation. Nature. 1972 May 26;237(5352):220–223. doi: 10.1038/237220a0. [DOI] [PubMed] [Google Scholar]
  2. Datta K., Thal L., Wajda I. J. Effects of morphone on choline acetyltransferase levels in the caudate nucleus of the rat. Br J Pharmacol. 1971 Jan;41(1):84–93. doi: 10.1111/j.1476-5381.1971.tb09938.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HANO K., KANETO H., KAKUNAGA T., MORIBAYASHI N. PHARMACOLOGICAL STUDIES OF ANALGESICS--VI. THE ADMINISTRATION OF MORPHINE AND CHANGES IN ACETYLCHOLINE METABOLISM MOUSE BRAIN. Biochem Pharmacol. 1964 Mar;13:441–447. doi: 10.1016/0006-2952(64)90164-9. [DOI] [PubMed] [Google Scholar]
  4. Hein G. E., Powell K. Evaluation of kinetic constants for mixed inhibitors of cholinesterase. Biochem Pharmacol. 1967 Mar;16(3):567–573. doi: 10.1016/0006-2952(67)90104-9. [DOI] [PubMed] [Google Scholar]
  5. Hemsworth B. A., Neal M. J. The effect of central stimulant drugs on acetylcholine release from rat cerebral cortex. Br J Pharmacol. 1968 Nov;34(3):543–550. doi: 10.1111/j.1476-5381.1968.tb08483.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. JOHANNESSON T. Morphine as an inhibitor of brain cholinesterases in morphine-tolerant and non-tolerant rats. Acta Pharmacol Toxicol (Copenh) 1962;19:23–35. [PubMed] [Google Scholar]
  7. Jhamandas K., Phillis J. W., Pinsky C. Effects of narcotic analgesics and antagonists on the in vivo release of acetylcholine from the cerebral cortex of the cat. Br J Pharmacol. 1971 Sep;43(1):53–66. doi: 10.1111/j.1476-5381.1971.tb07156.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jhamandas K., Pinsky C., Phillis J. W. Effects of morphine and its antagonists on release of cerebral cortical acetylcholine. Nature. 1970 Oct 10;228(5267):176–177. doi: 10.1038/228176a0. [DOI] [PubMed] [Google Scholar]
  9. Kerr F. W., Pozuelo J. Suppression of physical dependence and induction of hypersensitivity to morphine by stereotaxic hypothalamic lesions in addicted rats. A new theory of addiction. Mayo Clin Proc. 1971 Oct;46(10):653–665. [PubMed] [Google Scholar]
  10. PATON W. D. CHOLINERGIC TRANSMISSION AND ACETYLCHOLINE OUTPUT. Can J Biochem Physiol. 1963 Dec;41:2637–2653. [PubMed] [Google Scholar]
  11. PATON W. D. The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. Br J Pharmacol Chemother. 1957 Mar;12(1):119–127. doi: 10.1111/j.1476-5381.1957.tb01373.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. PELIKAN E. W. The mechanism of ganglionic blockade produced by nicotine. Ann N Y Acad Sci. 1960 Sep 27;90:52–69. doi: 10.1111/j.1749-6632.1960.tb32617.x. [DOI] [PubMed] [Google Scholar]
  13. Pinsky C., Frederickson R. C. Morphine and nalorphine impair neuromuscular transmission. Nat New Biol. 1971 May 19;231(20):94–96. doi: 10.1038/newbio231094a0. [DOI] [PubMed] [Google Scholar]
  14. SCHAUMANN W. Inhibition by morphine of the release of acetylcholine from the intestine of the guinea-pig. Br J Pharmacol Chemother. 1957 Mar;12(1):115–118. doi: 10.1111/j.1476-5381.1957.tb01372.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES