Skip to main content
British Journal of Pharmacology logoLink to British Journal of Pharmacology
letter
. 1973 Dec;49(4):709–711. doi: 10.1111/j.1476-5381.1973.tb08550.x

The calcium-dependent slow after-hyperpolarization in myenteric plexus neurones with tetrodotoxin-resistant action potentials

R A North
PMCID: PMC1776612  PMID: 4788043

Abstract

Intracellular recordings were made from neurones of the myenteric plexus of the guinea-pig ileum. The slow after-hyperpolarization which followed an action potential in some neurones was abolished by Mn++, La+++ and by solutions which contained no Ca++. In these neurones, the action potential and the slow after-hyperpolarization persisted in Na+-free solutions or in the presence of tetrodotoxin (2 μM). The findings suggest that an inward Ca++ current during the action potential is essential for the slow after-hyperpolarization.

Full text

PDF
709

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Gabella G. Fine structure of the myenteric plexus in the guinea-pig ileum. J Anat. 1972 Jan;111(Pt 1):69–97. [PMC free article] [PubMed] [Google Scholar]
  2. Hirst G. D., Spence I. Calcium action potentials in mammalian peripheral neurones. Nat New Biol. 1973 May 9;243(123):54–56. [PubMed] [Google Scholar]
  3. Krnjević K., Lisiewicz A. Injections of calcium ions into spinal motoneurones. J Physiol. 1972 Sep;225(2):363–390. doi: 10.1113/jphysiol.1972.sp009945. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Nishi S., North R. A. Intracellular recording from the myenteric plexus of the guinea-pig ileum. J Physiol. 1973 Jun;231(3):471–491. doi: 10.1113/jphysiol.1973.sp010244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Reuter H. Divalent cations as charge carriers in excitable membranes. Prog Biophys Mol Biol. 1973;26:1–43. doi: 10.1016/0079-6107(73)90016-3. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES